Zolbetuximab

Product Name: Zolbetuximab
CAS No.: 1496553-00-4
Chemical Name: Zolbetuximab
Synonyms: IMAB362;Zolbetuximab;Zolbetuximab (IMAB362);Research Grade Zolbetuximab;Zolbetuximab (anti-CLDN18.2);Research Grade Zolbetuximab (DHF19801)
CBNumber: CB08081041
Formula Weight: 0
MOL File: Mol file

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Zolbetuximab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Zolbetuximab Chemical Properties,Usage,Production

Uses

Zolbetuximab (development code IMAB362) is an experimental monoclonal antibody against isoform 2 of Claudin-18. It is under investigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors.

Mechanism of action

Zolbetuximab is the first drug developed against the target of Claudin18.2. It is a chimeric IgG1 monoclonal antibody that specifically binds to Claudin18.2 on the surface of tumor cells, thereby triggering antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), apoptosis and inhibition of cell proliferation.

in vivo

Zolbetuximab (200 μg, i.v.) alone and in combination with Gemcitabine (HY-17026) (50 mg/kg, i.p.) exhibits antitumor activity in mouse BxPC-3-CLDN18.2 xenograft models^[2].
Zolbetuximab (5.7 mg/kg, i.p., three times per week for five weeks) inhibits tumor growth in SNU-620 cells xenograft model^[3].

Animal Model:	mouse BxPC-3-CLDN18.2, MIA PaCa-2-CLDN18.2 xenograft model^[2]
Dosage:	200 μg alone or with 50 mg/kg Gemcitabine
Administration:	i.v.; i.p. (Gemcitabine)
Result:	Inhibited tumor growth in two models, and prevented lung metastasis formation. Prolonged survival time, and lowered fractions of CLDN18.2+ cells in MIA PaCa-2-CLDN18.2 xenograft.

Zolbetuximab Preparation Products And Raw materials

Raw materials

Preparation Products

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Zolbetuximab Suppliers

China 21 United States 1 Global 22

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1496553-00-4, ZolbetuximabRelated Search:

Oleclumab ipilimumab Cusatuzumab Dacetuzumab Cibisatamab Selicrelumab Galcanezumab Rovalpituzumab Tinurilimab Eculizumab

Zolbetuximab

Research Grade Zolbetuximab (DHF19801)

Zolbetuximab (IMAB362)

Research Grade Zolbetuximab

IMAB362

Zolbetuximab (anti-CLDN18.2)

1496553-00-4