Cusatuzumab
- Product Name
- Cusatuzumab
- CAS No.
- 1399546-01-0
- Chemical Name
- Cusatuzumab
- Synonyms
- Cusatuzumab;Research Grade Cusatuzumab;Research Grade Cusatuzumab(DHE01901)
- CBNumber
- CB58081071
- Formula Weight
- 0
- MOL File
- Mol file
Cusatuzumab Chemical Properties,Usage,Production
Description
Cusatuzumab is designed as a first-in-class, high-affinity anti-CD70 monoclonal antibody with multiple intended mechanisms of action, including Fc-mediated cytotoxicity with enhanced ADCC and inhibition of CD70/CD27 signaling, resulting in killing of malignant cells such as leukemia blasts and stem cells.
Definition
cusatuzumab is a defucosylated, humanized IgG1 monoclonal antibody directed against the extracellular domain of the human CD70 molecule with potential antineoplastic activity. Upon administration, cusatuzumab selectively binds to, and neutralizes the activity of CD70, which may also induce an antibody-dependent cellular cytotoxicity (ADCC) response against CD70-expressing tumor cells. CD70, the ligand for the costimulatory receptor CD27 and a member of the tumor necrosis factor (TNF) family, is found on a number of solid and hematological tumors. Its overexpression may play an important role in evasion of immune surveillance.
Synonym: anti-CD70 monoclonal antibody ARGX-110
Code name: ARGX-110
Cusatuzumab Preparation Products And Raw materials
Raw materials
Preparation Products
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