ChemicalBook > CAS DataBase List > citatuzumab

citatuzumab

Product Name
citatuzumab
CAS No.
896731-82-1
Chemical Name
citatuzumab
Synonyms
Conatumumab;citatuzumab;TRAIL-R2 mAb|||AMG 655;Research Grade Conatumumab;Research Grade Citatuzumab;Research Grade Conatumumab(DHA29103)
CBNumber
CB01518498
Formula Weight
0
MOL File
Mol file
More
Less

citatuzumab Property

form 
Liquid
color 
Colorless to light yellow
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0006504
Product name
CONATUMUMAB
Purity
95.00%
Packaging
5MG
Price
$499.07
Updated
2021/12/16
More
Less

citatuzumab Chemical Properties,Usage,Production

Uses

Conatumumab (AMG 655) is a human monoclonal agonist antibody against human death receptor 5 (DR5, TRAILR2) (Kd: 1 nM for the long form of DR5, 0.8 nM for the short form of DR5). Conatumumab induces apoptosis via caspase activation. Conatumumab can be used in the research of cancers. [1][2][3].

in vivo

Conatumumab (0-100 μg, i.p., twice weekly) inhibits tumor growth in mice bearing Colo205, H2122, or MiaPaCa2/T2 xenograft tumors[2].
Conatumumab (2.5 μg, i.p., three times per week) enhances the antitumor activity of chemotherapeutics (CPT11, HY-16562) (80 mg/kg) in Colo 205 xenograft[2].

Animal Model:Mice bearing Colo205, H2122, or MiaPaCa2/T2 xenograft tumors[2]
Dosage:0, 0.1, 0.3, 1, 3, 10, 30, 100 μg
Administration:Intraperitoneal injection (i.p.), twice weekly.
Result:Dose-dependently inhibited tumor growth.
Induced caspase-3 activation in tumors (determined by IHC).

References

[1] Herbst RS, et al. A first-in-human study of conatumumab in adult patients with advanced solid tumors. Clin Cancer Res. 2010 Dec 1;16(23):5883-91. DOI:10.1158/1078-0432.CCR-10-0631
[2] Kaplan-Lefko PJ, et al. Conatumumab, a fully human agonist antibody to death receptor 5, induces apoptosis via caspase activation in multiple tumor types. Cancer Biol Ther. 2010 Apr 15;9(8):618-31. DOI:10.4161/cbt.9.8.11264

citatuzumab Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

citatuzumab Suppliers

China 21 United States 3 Global 24
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
American Custom Chemicals Corporation
Tel
--
Fax
--
Email
sales@acccorporation.com
Country
United States
ProdList
6820
Advantage
51
Wonda Science
Tel
--
Fax
--
Email
wonda@wondascience.com
Country
United States
ProdList
2192
Advantage
50

896731-82-1, citatuzumabRelated Search:

Blinatumomab Zolbetuximab Theralizumab Sirukumab Serclutamab Sacituzumab Pembrolizumab Vatelizumab Nurulimab Mirikizumab

  • citatuzumab
  • Conatumumab
  • Research Grade Conatumumab(DHA29103)
  • TRAIL-R2 mAb|||AMG 655
  • Research Grade Citatuzumab
  • Research Grade Conatumumab
  • 896731-82-1