ChemicalBook > CAS DataBase List > Donepezil
Donepezil
- Product Name
- Donepezil
- CAS No.
- 120014-06-4
- Chemical Name
- Donepezil
- Synonyms
- 5,6-Dimethoxy-2,3-dihydro-1H-inden-1-one;Donepenil;Donezepil;2-((1-Benzylpiperidin-4-yl)Methyl)-5,6-diMethoxy-2,3-dihydro-1H-inden-1-one;Donepezilo;N-Benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl] piperidine;2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-1h-inde;n-1-one;onepezil;HSDB7743
- CBNumber
- CB0156314
- Molecular Formula
- C24H29NO3
- Formula Weight
- 379.49
- MOL File
- 120014-06-4.mol
More
Less
Donepezil Property
- Melting point:
- 207°C
- Boiling point:
- 527.9±50.0 °C(Predicted)
- Density
- 1.141±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Acetone (Slightly), Chloroform (Slightly)
- form
- Solid
- pka
- 8.84±0.10(Predicted)
- color
- White to Off-White
- Water Solubility
- 2.931 mg/L
- CAS DataBase Reference
- 120014-06-4(CAS DataBase Reference)
More
Less
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-36/37/39
- RIDADR
- UN 2811
- HS Code
- 29333990
- Hazardous Substances Data
- 120014-06-4(Hazardous Substances Data)
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
More
Less
N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 13245
- Product name
- Donepezil
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $32
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 13245
- Product name
- Donepezil
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $73
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 13245
- Product name
- Donepezil
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $121
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 13245
- Product name
- Donepezil
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $230
- Updated
- 2024/03/01
TRC
- Product number
- D525745
- Product name
- Donepezil
- Packaging
- 500mg
- Price
- $210
- Updated
- 2021/12/16
More
Less
Donepezil Chemical Properties,Usage,Production
Description
Donepezil is another “nonclassic,” centrally acting, reversible, noncompetitive AChEI that was approved in 1997 for treatment of mild-to-moderate AD and dementia. Its selectivity for AChE is 570- to 1,250-fold that for butyrylcholinesterase, and it also exhibits greater affinity for brain AChE than for AChE in the periphery.
Uses
Donepezil is a cholinesterase inhibitors.
Uses
Acetylcholine is a neurotransmitter involved in neural signaling throughout the body. Donepezil is a reversible acetylcholinesterase inhibitor that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine. It has a half-life in circulation of about 70 hours. As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil is commonly used in the treatment of Alzheimer’s disease to improve cognition, memory, and behavior. In this way, it is intended to prevent or reverse dementia. Studies on these effects have been equivocal, indicating that more research into the therapeutic potential of donepezil is warranted.[Cayman Chemical]
Definition
ChEBI: Donepezil is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
brand name
Aricept (Eisai Medical Research).
General Description
Donepezil, (±)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one (Aricept), commonly referred to in the literature asE2020, is a reversible inhibitor of AChE. It is indicated forthe treatment of symptoms of mild-to-moderate Alzheimerdisease. Donepezil is approximately 96% bound to plasmaproteins, with an elimination half-life of 70 hours. It is metabolizedprincipally by the 2D6 and 3A4 isozymes of theP450 system.
Metabolism
When compared to tacrine, donepezil exhibits greater CNS AChE selectivity, longer elimination half-life (70–104 hours in subjects older than 55 years) and little or no potential for hepatotoxicity. Donepezil is metabolized by CYP2D6 and CYP3A4 via demethylation, debenzylation, hydroxylation, oxidation to the cis-N-oxide, and glucuronidation. The 6-O-desmethyl metabolite accounts for 11% of a dose, and it exhibits AChE inhibitory activity comparable to that of the parent compound.
Donepezil Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
Donepezil Suppliers
- Tel
- 0531-82375880 15098789112
- 2710825968@qq.com
- Country
- China
- ProdList
- 309
- Advantage
- 58
- Tel
- +86-515-84383180
- Fax
- +86-515-84383182
- sales@medicalchem.com
- Country
- China
- ProdList
- 80
- Advantage
- 69
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15839
- Advantage
- 69
- Tel
- 010-89508211 18501085097
- Fax
- 010-89508210
- sales.bj@hwrkchemical.com
- Country
- China
- ProdList
- 8418
- Advantage
- 55
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44688
- Advantage
- 61
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9512
- Advantage
- 66
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42958
- Advantage
- 64
- Tel
- 15527768850
- 1791901229@qq.com
- Country
- China
- ProdList
- 8836
- Advantage
- 52
- Tel
- +86 (21) 6435-5022
- Country
- China
- ProdList
- 4267
- Advantage
- 65
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12984
- Advantage
- 57
- Tel
- 0571-82693216
- Fax
- +86-571-82880190
- info@yuhaochemical.com
- Country
- China
- ProdList
- 9387
- Advantage
- 52
- Tel
- 027-59207852 13308628970
- Fax
- QQ3130921841
- buy@fortunachem.com
- Country
- China
- ProdList
- 2865
- Advantage
- 58
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
- Country
- China
- ProdList
- 4727
- Advantage
- 58
- Tel
- 021-61312847 13636370518
- Fax
- 021-55068248
- shyysw007@163.com
- Country
- China
- ProdList
- 4940
- Advantage
- 60
- Tel
- 4008-755-333 18080918076
- Fax
- 028-86757656
- 800078821@qq.com
- Country
- China
- ProdList
- 9718
- Advantage
- 55
- Tel
- 0755-4000505016 13380397412
- Fax
- 0755 28094224
- 3001272453@qq.com
- Country
- China
- ProdList
- 5047
- Advantage
- 50
- Tel
- 024-31298370 15040047923
- Fax
- 024-62665110
- yuanchengchem@163.com
- Country
- China
- ProdList
- 252
- Advantage
- 52
- Tel
- 010-56205725
- Fax
- 010-65763397
- waley188@sohu.com
- Country
- China
- ProdList
- 12335
- Advantage
- 58
- Tel
- +86-21-60341587
- Fax
- +86-21-61294319
- sales@topbiochem.com
- Country
- China
- ProdList
- 6175
- Advantage
- 58
- Tel
- 400-400-6206333 18521732826
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 021-61552785
- Fax
- 021-55660885
- sales@shshiji.com
- Country
- China
- ProdList
- 9545
- Advantage
- 55
- Tel
- +86-28-85122536 85324413
- Fax
- +86-28-85326443
- market@astatech.cn
- Country
- China
- ProdList
- 8026
- Advantage
- 55
- Tel
- 025-57798810
- Fax
- 025-57019371
- sales@sunlidabio.com
- Country
- China
- ProdList
- 3239
- Advantage
- 55
- Tel
- +86-317-3563899
- Fax
- +86-317-3563199
- trade@senary.com
- Country
- China
- ProdList
- 98
- Advantage
- 56
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7783
- Advantage
- 58
- Tel
- 13971561712, 13995564702, 027-50664929
- Fax
- 027-50664927
- hbeixys2001@163.com
- Country
- China
- ProdList
- 3120
- Advantage
- 55
- Tel
- 15722085254
- Fax
- 022-26358246
- phytochemical@126.com
- Country
- China
- ProdList
- 813
- Advantage
- 55
- Tel
- 021-60549325 18616193163
- Fax
- 021-33250306
- Country
- China
- ProdList
- 4526
- Advantage
- 56
- Tel
- 400-0066400 13621662912
- Fax
- 021-55660885
- 422131432@qq.com
- Country
- China
- ProdList
- 9978
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41462
- Advantage
- 60
- Tel
- 021-54359730 400-008-9730
- Fax
- 021-54353864
- info@chemxyz.com
- Country
- China
- ProdList
- 3991
- Advantage
- 60
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 18070
- Advantage
- 56
- Tel
- 400-1166-196 13458535857
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 13350
- Advantage
- 58
- Tel
- 027-87465837 19945049750
- Fax
- 027-8777-2287
- sales@finetechnology-ind.com
- Country
- China
- ProdList
- 9648
- Advantage
- 58
- Tel
- 15221275939 15221275939
- Fax
- 021-50706099
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 16166
- Advantage
- 55
- Tel
- 0571-+86-571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 11578
- Advantage
- 59
- Tel
- +86-021-61654350
- Fax
- +86-021-61654350
- 1245958370@qq.com
- Country
- China
- ProdList
- 2982
- Advantage
- 50
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2990
- Advantage
- 60
- Tel
- 027-59599241 18871490274
- Fax
- 027-59599241
- 1400878000@qq.com
- Country
- China
- ProdList
- 9958
- Advantage
- 58
- Tel
- +86-21-5821 5861
- Fax
- +86-21-5106 2861
- sales@letopharm.com
- Country
- China
- ProdList
- 2384
- Advantage
- 58
- Tel
- Fax
- -
- xg01_gj@163.com
- Country
- China
- ProdList
- 9484
- Advantage
- 50
- Tel
- 023-68980308
- Fax
- 023-68980318
- business@cqlandtower.com
- Country
- China
- ProdList
- 37
- Advantage
- 55
- Tel
- 531-88883606 15688880361
- Fax
- +86-531-69950228 QQ839101288 QQ2793626495
- sales@jnrxchem.com
- Country
- China
- ProdList
- 111
- Advantage
- 55
- Tel
- 027-59207879 1972026995 18140587686
- Fax
- QQ：1972026995
- sales@3600chem.com
- Country
- China
- ProdList
- 4660
- Advantage
- 55
- Tel
- 025-66023220 0086-15250997978
- Fax
- 025-58362220
- 1511893459@qq.com
- Country
- China
- ProdList
- 7892
- Advantage
- 55
- Tel
- 0512-0512-63009836 15365350169
- Fax
- 0512-63006936
- helen@struchem.com
- Country
- China
- ProdList
- 3984
- Advantage
- 60
- Tel
- 025-58862853 18915922038
- Fax
- +86-025-58862853
- sales@endesachem.com
- Country
- China
- ProdList
- 591
- Advantage
- 58
- Tel
- 18620099427
- Fax
- +86-20-62619665
- amy@howeipharm.com
- Country
- China
- ProdList
- 17687
- Advantage
- 55
- Tel
- +86-400-851-9921
- Fax
- +86-10-82826195
- sales@pharmacodia.com
- Country
- China
- ProdList
- 2317
- Advantage
- 55
- Tel
- 0575-18780151478 18582380095
- Fax
- 0575-89298961
- sales@artisbio.com
- Country
- China
- ProdList
- 3044
- Advantage
- 58
More
Less
View Lastest Price from Donepezil manufacturers
Sinoway Industrial co., ltd.
- Product
- Donepezil 120014-06-4
- Price
- US $0.00/Kg/Bag
- Min. Order
- 2Kg/Bag
- Purity
- 99% up, High Density
- Supply Ability
- 20 tons
- Release date
- 2022-10-18
Anhui Dexinjia Biopharm Co., Ltd
- Product
- Donepezil 120014-06-4
- Price
- US $200.00-150.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 20tons
- Release date
- 2024-05-20
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- Donepezil 120014-06-4
- Price
- US $0.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 1200kg/month
- Release date
- 2021-06-07
120014-06-4, DonepezilRelated Search:
RAC (CIS/TRANS) DONEPEZIL N-OXIDE
Scopolamine
5-(1-Hydroxy-2-tert-butylamino-ethyl)benzene-1,3-diol
(S)-(+)-Benzyl glycidyl ether
XWAIAVWHZJNZQQ-RPXFAUAJSA-N
Nimodipine
Aniracetam
Metformin
Paroxetine
Piracetam
Oxiracetam
Donepezil Hydrochloride
Memantine
Rivastigmine
5,6-Dimethoxy-2-(pyridine-4-yl)methylene-indan-1-one
5-O-Desmethyl Donepezil
2-[(E)-(1-BENZYL-4-PIPERIDINYL)METHYLIDENE]-5,6-DIMETHOXY-1-INDANONE
Dihydro Donepezil
(Mixture of Diastereomers)