Rivastigmine
- Product Name
- Rivastigmine
- CAS No.
- 123441-03-2
- Chemical Name
- Rivastigmine
- Synonyms
- RIVASTIGMINE HYDROGEN TARTRATE;EXELON;Rivastigmine base;mine;Rivastig;cabalatine;Revastigmine;RIVASTIGMINE;RivastigiMine;S-RivastigMine
- CBNumber
- CB8328151
- Molecular Formula
- C14H22N2O2
- Formula Weight
- 250.34
- MOL File
- 123441-03-2.mol
Rivastigmine Property
- alpha
- D20 -32.1° (c = 5 in ethanol)
- Boiling point:
- 316.2±34.0 °C(Predicted)
- Density
- 1.038±0.06 g/cm3(Predicted)
- Flash point:
- 145℃
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Chloroform (Sparingly), Ethyl Acetate (Slightly)
- form
- Powder
- pka
- pKa 8.99 (Uncertain)
- CAS DataBase Reference
- 123441-03-2(CAS DataBase Reference)
Safety
- RIDADR
- UN 2810 6.1 / PGIII
- HS Code
- 2924296000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P391Collect spillage. Hazardous to the aquatic environment
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- PHR3343
- Product name
- Rivastigmine
- Purity
- certified reference material, pharmaceutical secondary standard
- Packaging
- 0.2ML
- Price
- $228
- Updated
- 2024/03/01
- Product number
- 1604836
- Product name
- Rivastigmine
- Packaging
- 0.1ml
- Price
- $460
- Updated
- 2024/03/01
- Product number
- R540995
- Product name
- (S)-Rivastigmine
- Packaging
- 2g
- Price
- $350
- Updated
- 2021/12/16
- Product number
- 61620
- Product name
- (S)-Rivastigmine
- Packaging
- 5G
- Price
- $1380
- Updated
- 2021/12/16
- Product number
- API0008913
- Product name
- Rivastigmine
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $2945.25
- Updated
- 2021/12/16
Rivastigmine Chemical Properties,Usage,Production
Uses
Antidepressant
Definition
ChEBI: A carbamate ester obtained by formal condensation of the carboxy group of ethyl(methyl)carbamic acid with the phenolic OH group of 3-[(1S)-1-(dimethylamino)ethyl]phenol. A reversible cholinesterase inhibitor.
brand name
Exelon (Novartis).
General Description
Rivastigmine (Exelon, EA 713) is apseudoirreversible noncompetitive carbamate inhibitor ofAChE. Although the half-life is approximately 2 hours,the inhibitory properties of this agent last for 10 hours becauseof the slow dissociation of the drug from the enzyme.The Food and Drug Administration (FDA) approved its usein mild-to-moderate Alzheimer disease in April 2000. InJuly 2007, rivastigmine was granted approval for use inmanaging mild-to-moderate dementia associated withParkinson disease.
Pharmacokinetics
Rivastigmine is a centrally selective, arylcarbamate AChEI that was approved in 2000 for oral administration in the treatment of AD. It has an elimination half-life of 1.4 to 1.7 hours but is able to inhibit AChE for up to 10 hours. Because of the slow dissociation of the carbamylated enzyme, it has been referred to as a pseudo-irreversible AChEI. Like donepezil, rivastigmine exhibits a low level of hepatotoxicity. It is rapidly and extensively hydrolyzed in the CNS by cholinesterase with minimal involvement of CYP450. The phenolic metabolite is excreted primarily via the kidneys.
Clinical Use
Mild-moderate dementia in Alzheimer’s disease
Idiopathic Parkinson’s disease
Drug interactions
Potentially hazardous interactions with other drugs
Muscle relaxants: enhances effect of suxamethonium;
antagonises effect of non-depolarising muscle
relaxants.
Metabolism
Rivastigmine is the tertiary amines that are rapidly absorbed from the gastrointestinal tract, as are tacrine, donepezil, and galanthamine, whereas quaternary ammonium compounds are poorly absorbed after oral administration. Nevertheless, quaternary ammonium compounds like neostigmine and pyridostigmine are orally active if larger doses are employed. Only the quaternary ammonium inhibitors do not readily enter the CNS. Because of their high lipid solubility and low molecular weight, most of the organophosphates are absorbed by all routes of administration; even percutaneous exposure can result in the absorption of sufficient drug to permit the accumulation of toxic levels of these compounds.
Rivastigmine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Rivastigmine manufacturers
- Product
- Rivastigmine 123441-03-2
- Price
- US $110.00-90.00/kilogram
- Min. Order
- 1kilogram
- Purity
- 99%
- Supply Ability
- 10 tons/per week
- Release date
- 2023-12-27
- Product
- Rivastigmine 123441-03-2
- Price
- US $15.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2023-01-06
- Product
- Rivastigmine 123441-03-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-01