ChemicalBook > CAS DataBase List > Rivastigmine

Rivastigmine

Product Name
Rivastigmine
CAS No.
123441-03-2
Chemical Name
Rivastigmine
Synonyms
RIVASTIGMINE HYDROGEN TARTRATE;EXELON;Rivastigmine base;mine;Rivastig;cabalatine;Revastigmine;RIVASTIGMINE;RivastigiMine;S-RivastigMine
CBNumber
CB8328151
Molecular Formula
C14H22N2O2
Formula Weight
250.34
MOL File
123441-03-2.mol
More
Less

Rivastigmine Property

alpha 
D20 -32.1° (c = 5 in ethanol)
Boiling point:
316.2±34.0 °C(Predicted)
Density 
1.038±0.06 g/cm3(Predicted)
Flash point:
145℃
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Chloroform (Sparingly), Ethyl Acetate (Slightly)
form 
Powder
pka
pKa 8.99 (Uncertain)
CAS DataBase Reference
123441-03-2(CAS DataBase Reference)
More
Less

Safety

RIDADR 
UN 2810 6.1 / PGIII
HS Code 
2924296000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR3343
Product name
Rivastigmine
Purity
certified reference material, pharmaceutical secondary standard
Packaging
0.2ML
Price
$228
Updated
2024/03/01
Sigma-Aldrich
Product number
1604836
Product name
Rivastigmine
Packaging
0.1ml
Price
$460
Updated
2024/03/01
TRC
Product number
R540995
Product name
(S)-Rivastigmine
Packaging
2g
Price
$350
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
61620
Product name
(S)-Rivastigmine
Packaging
5G
Price
$1380
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008913
Product name
Rivastigmine
Purity
95.00%
Packaging
5G
Price
$2945.25
Updated
2021/12/16
More
Less

Rivastigmine Chemical Properties,Usage,Production

Uses

Antidepressant

Definition

ChEBI: A carbamate ester obtained by formal condensation of the carboxy group of ethyl(methyl)carbamic acid with the phenolic OH group of 3-[(1S)-1-(dimethylamino)ethyl]phenol. A reversible cholinesterase inhibitor.

brand name

Exelon (Novartis).

General Description

Rivastigmine (Exelon, EA 713) is apseudoirreversible noncompetitive carbamate inhibitor ofAChE. Although the half-life is approximately 2 hours,the inhibitory properties of this agent last for 10 hours becauseof the slow dissociation of the drug from the enzyme.The Food and Drug Administration (FDA) approved its usein mild-to-moderate Alzheimer disease in April 2000. InJuly 2007, rivastigmine was granted approval for use inmanaging mild-to-moderate dementia associated withParkinson disease.

Pharmacokinetics

Rivastigmine is a centrally selective, arylcarbamate AChEI that was approved in 2000 for oral administration in the treatment of AD. It has an elimination half-life of 1.4 to 1.7 hours but is able to inhibit AChE for up to 10 hours. Because of the slow dissociation of the carbamylated enzyme, it has been referred to as a pseudo-irreversible AChEI. Like donepezil, rivastigmine exhibits a low level of hepatotoxicity. It is rapidly and extensively hydrolyzed in the CNS by cholinesterase with minimal involvement of CYP450. The phenolic metabolite is excreted primarily via the kidneys.

Clinical Use


Mild-moderate dementia in Alzheimer’s disease
Idiopathic Parkinson’s disease

Drug interactions

Potentially hazardous interactions with other drugs
Muscle relaxants: enhances effect of suxamethonium; antagonises effect of non-depolarising muscle relaxants.

Metabolism

Rivastigmine is the tertiary amines that are rapidly absorbed from the gastrointestinal tract, as are tacrine, donepezil, and galanthamine, whereas quaternary ammonium compounds are poorly absorbed after oral administration. Nevertheless, quaternary ammonium compounds like neostigmine and pyridostigmine are orally active if larger doses are employed. Only the quaternary ammonium inhibitors do not readily enter the CNS. Because of their high lipid solubility and low molecular weight, most of the organophosphates are absorbed by all routes of administration; even percutaneous exposure can result in the absorption of sufficient drug to permit the accumulation of toxic levels of these compounds.

Rivastigmine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Rivastigmine Suppliers

Canada 2 China 230 Europe 2 India 31 Italy 1 Mexico 2 Slovakia 1 South Korea 1 Sweden 1 Switzerland 1 United Kingdom 6 United States 31 Global 309
ForeChem (Nantong) Technology Co.,Ltd.
Tel
513-85982855 18921614129
Fax
051385915507
Email
sales@xianxingpharm.com
Country
China
ProdList
1819
Advantage
61
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057 18501085097
Fax
010-89508210
Email
sales3.gd@hwrkchemical.com
Country
China
ProdList
7639
Advantage
55
Beijing Mediking Biopharm Co., Ltd
Tel
010-81769521,89753524,81760121 15901403431
Fax
+86-10-81769652
Email
sales01@mediking.cn
Country
China
ProdList
99
Advantage
68
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9550
Advantage
66
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
14113
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
18089
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
Country
China
ProdList
42982
Advantage
64
Daicel Chiral Technologies (China)CO.,LTD
Tel
021-50460086-9 15921403865
Fax
+86-21-50462321
Email
han_yajun@dctc.daicel.com
Country
China
ProdList
6854
Advantage
65
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4941
Advantage
60
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
4968
Advantage
50
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-83725681-603
Fax
+86 755 28094224
Country
China
ProdList
4505
Advantage
50
Suzhou Sibian Chemical Technology Co.,Ltd.
Tel
0512-65617459 18915409046
Fax
0512-65617459
Email
sales@sibian-chem.com
Country
China
ProdList
1927
Advantage
55
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12338
Advantage
58
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1494
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
Candia Thamtech Company Limited
Tel
0371-86615086 18203638366 0371-86159066 13526786601
Fax
0371-86159066
Country
China
ProdList
2017
Advantage
60
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
18521735133 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25014
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9552
Advantage
55
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3750
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7854
Advantage
58
Hubei lansan Biochemical Pharmaceutical Co., Ltd.
Tel
86-714-6395877
Fax
86-714-6395835
Country
China
ProdList
26
Advantage
58
DONGSHENG CHIRAL PHARMA
Tel
180000000
Email
3755454181@qq.com
Country
China
ProdList
419
Advantage
55
Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712, 13995564702, 027-50664929
Fax
027-50664927
Email
hbeixys2001@163.com
Country
China
ProdList
3123
Advantage
55
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41438
Advantage
60
Shanghai DiBai Chemicals Co., Ltd.
Tel
021-54359730 400-008-9730
Fax
021-54353864
Email
info@chemxyz.com
Country
China
ProdList
3993
Advantage
60
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
17994
Advantage
56
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4951
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10287
Advantage
55
Shandong Boluoda Biological Technology Co., Ltd.
Tel
0531-58190570 15863796298
Email
2310993908@qq.com
Country
China
ProdList
332
Advantage
58
Hangzhou J&H Chemical Co., Ltd.
Tel
+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
10015
Advantage
53
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9798
Advantage
50
Chengdu Aslee Biopharmaceuticals, Inc
Tel
028-85305008 02885305008
Fax
4000210878-186
Email
2306208234@qq.com
Country
China
ProdList
1005
Advantage
50
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9767
Advantage
58
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9972
Advantage
58
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9503
Advantage
50
Guangzhou Ciming Biological Technology Co., Ltd.
Tel
020-38082199,29065168,38082986,29878298,29866629,4000192398
Fax
+86 (20)38082986
Country
China
ProdList
831
Advantage
60
Dalian Wondersun Biochemical Technology Co., Ltd.
Tel
0411-88165855
Fax
0411-88165855
Email
sales@wdspharma.com
Country
China
ProdList
56
Advantage
50
AN PharmaTech Co Ltd
Tel
86(21)68097365
Fax
86(21)33321566
Email
sales@anpharma.net
Country
China
ProdList
4901
Advantage
55
DebyeTec.com Inc.
Tel
18086626237 18086626237
Fax
qq:2693528373
Email
sales@debyesci.com
Country
China
ProdList
2643
Advantage
56
Suzhou Xinkai Bio-Medical Technology Co., Ltd.
Tel
0512-67213637 13952409868
Email
peter19zhang@163.com
Country
China
ProdList
452
Advantage
55
ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862，442785678，326799392 18721037013
Fax
021-50908862
Email
siyansales@126.com
Country
China
ProdList
9638
Advantage
58
Artis Biotech Co. Ltd.
Tel
19138486554 18582380095
Fax
0575-89298961
Email
sales@artisbio.com
Country
China
ProdList
2862
Advantage
58
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3868
Advantage
58
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9934
Advantage
55
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9604
Advantage
55
ChangSha kangpeng Pharmaceutical Co., Ltd.
Tel
18229909706
Fax
-
Email
3249713892@qq.com
Country
China
ProdList
82
Advantage
55
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20810
Advantage
60
Cangzhou Enke Pharma-tech Co., Ltd.
Tel
0317-5296180 15533709196
Fax
0317-5106596
Email
sale@enkepharma.com
Country
China
ProdList
1647
Advantage
55
Raw material medicin reagent co.,Ltd
Tel
025-57798860
Email
sales@njromanme.com
Country
China
ProdList
4534
Advantage
58
More
Less

View Lastest Price from Rivastigmine manufacturers

Henan Tengmao Chemical Technology Co. LTD
Product
Rivastigmine 123441-03-2
Price
US $110.00-90.00/kilogram
Min. Order
1kilogram
Purity
99%
Supply Ability
10 tons/per week
Release date
2023-12-27
Hebei Duling International Trade Co. LTD
Product
Rivastigmine 123441-03-2
Price
US $15.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2023-01-06
Hebei Mojin Biotechnology Co., Ltd
Product
Rivastigmine 123441-03-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-01

123441-03-2, RivastigmineRelated Search:

Ethyl acetate Ethylparaben 4-Aminobenzoic acid Tris(trimethylsilyl)phosphate Urethane ISOXADIFEN-ETHYL Methyl anthranilate PHENYL VALERATE 3-Dimethylaminopropylamine Neostigmine bromide 4-Dimethylaminobenzaldehyde Diphenyl ether Dimethyl phthalate Ethanol Phenyl salicylate POLYURETHANE PHENYL RESIN Rivastigmine tartrate,Rivastigmine-d6 tartarate,RIVASTIGMINE TARTRATE SALT,Rivastigmine tartrate; SDZ-ENA 713

  • (S)-N-Ethyl-N-Methyl- 3-[1-(diMethylaMino)ethyl]- phenyl carbaMate
  • S-RivastigMine
  • CarbaMic acid, N-ethyl-N-Methyl-, 3-[(1S)-1-(diMethylaMino)ethyl]phenyl ester
  • RivastigiMine
  • Rivastigmine base
  • bis(sulfanylidene)ruthenium
  • (S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)carbamate
  • Revastigmine
  • N-Ethyl-N-methylcarbamic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl-ester
  • Revastigmine (S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)carbamate
  • Rivastigmine Base/ Tartrate
  • EXELON
  • RIVASTIGMINE
  • RIVASTIGMINE HYDROGEN TARTRATE
  • RIVASTIGIMINE(FORR&DONLY)
  • 3-((1S)-1-(Dimethylamino)ethyl)phenyl N-ethyl-N-methylcarbamate
  • Ethylmethylcarbamic acid 3-((1S)-1-(dimethylamino)ethyl)phenyl ester
  • 3-((1S)-1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate
  • Carbamic acid, ethylmethyl-, 3-((1S)-1-(dimethylamino)ethyl)phenyl ester
  • Carbamic acid, ethylmethyl-, 3-(1-(dimethylamino)ethyl)phenyl ester, (S)-
  • Ena 713 free base
  • Unii-pki06m3iw0
  • Rivastigmine (0.1 mL)
  • (S)-3-[1-(diMethylaMino)ethyl]phenyl N-ethyl-N-MethylcarbaMate
  • Rivastigmine for system suitability CRS
  • mine
  • Rivastig
  • Rivastigmine USP/EP/BP
  • Rivastigmine intermediate,Rivastigmine
  • Rivastigmine (1604836)
  • Benzo[b]thiophene-2-carboxylicacid,3-chloro-5,10-dimethoxy-,methylester
  • Rivastigmine Monomer
  • Rivastigmine Impurity
  • cabalatine
  • 123441-03-2
  • 320-67-4