2'',3'',5''-Triacetyl -azacytidine

Product Name: 2'',3'',5''-Triacetyl -azacytidine
CAS No.: 10302-78-0
Chemical Name: 2'',3'',5''-Triacetyl -azacytidine
Synonyms: Nsc291930;-O-triacetate;Triacetyl azacitidine;Azacitidine Triacetate;Azacitidine Impurity 48;Intermediate of Azacitidine;2'3'5'-triacetyl-5-Azacytosine;2',3',5'-triacetyl-5-Azacytidine;2',3',5'-Tri-O-Acetyl-Azacytidine;2'',3'',5''-Triacetyl -azacytidine
CBNumber: CB01564248
Molecular Formula: C14H18N4O8
Formula Weight: 370.31
MOL File: 10302-78-0.mol

More

Less

2'',3'',5''-Triacetyl -azacytidine Property

Boiling point:: 497.3±55.0 °C(Predicted)
Density: 1.60±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
form: crystalline solid
pka: 3.06±0.20(Predicted)
CAS DataBase Reference: 10302-78-0

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 13373
Product name: 2',3',5'-triacetyl-5-Azacytidine
Purity: ≥95%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 13373
Product name: 2',3',5'-triacetyl-5-Azacytidine
Purity: ≥95%
Packaging: 10mg
Price: $115
Updated: 2024/03/01

Cayman Chemical

Product number: 13373
Product name: 2',3',5'-triacetyl-5-Azacytidine
Purity: ≥95%
Packaging: 50mg
Price: $477
Updated: 2024/03/01

Cayman Chemical

Product number: 13373
Product name: 2',3',5'-triacetyl-5-Azacytidine
Purity: ≥95%
Packaging: 100mg
Price: $834
Updated: 2024/03/01

TRC

Product number: A796030
Product name: 5-Azacytidine2’,3’5’-O-triacetate
Packaging: 50mg
Price: $265
Updated: 2021/12/16

More

Less

2'',3'',5''-Triacetyl -azacytidine Chemical Properties,Usage,Production

Description

5-Azacytidine is an inhibitor of DNA methyltransferase, potentially serving to reverse epigenetic changes. It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes and cancer. 2’,3’,5’-triacetyl-5-Azacytidine is a prodrug form of 5-azacytidine that may be rapidly absorbed orally without formation of major metabolites in the gastrointestinal tract.

Chemical Properties

White to off-white powder

Uses

5-Azacytidine is an inhibitor of DNA methyltransferaes, potentially serving to reverse epigenetic changes. It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes and cancer. 2’,3’,5’-triacetyl-5-Azacytidine is a prodrug form of 5-azacytidine that may be rapidly absorbed orally without formation of major metabolites in the gastrointestinal tract.[Cayman Chemical]

in vivo

in cd-1 mice, oral administration of tac for five days per week for 2 weeks didn’t result in animal deaths and weight loss, but induced changes in hematological parameters, lymph nodes, bone marrow, and duodenal epithelium. tac inhibited global dna methylation in the spleen and gut. in an in vivo l1210 leukemia model, tac exhibited antineoplastic activity [1].

References

[1] ziemba a, ramirez m c, freeman b, et al. abstract# 3369: development of oral demethylating agents for the treatment of myelodysplastic syndrome[j]. 2009.
[2] brueckner b, boy r g, siedlecki p, et al. epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human dna methyltransferases[j]. cancer research, 2005, 65(14): 6305-6311.

2'',3'',5''-Triacetyl -azacytidine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2'',3'',5''-Triacetyl -azacytidine Suppliers

China 80 India 4 United Kingdom 2 United States 10 USA 1 Global 97

Wuhu Huaren Science and Technology Co., Ltd.

Tel: 0553-0553-5842013-801 18155347026
Fax: 086-553-5843138
Email: sale@huarensh.com
Country: China
ProdList: 296
Advantage: 64

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: zhangsn@titansci.com
Country: China
ProdList: 14113
Advantage: 59

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 17988
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 4550
Advantage: 62

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-4000505016 13380397412
Fax: 0755 28094224
Email: 3001272453@qq.com
Country: China
ProdList: 4978
Advantage: 50

Hangzhou Sage Chemical Co., Ltd.

Tel: +86057186818502 13588463833
Fax: Pls mail us for more information!
Email: info@sagechem.com
Country: China
ProdList: 10269
Advantage: 58

Beijing Comparison Pharmaceutical Technology Co., Ltd

Tel: 010-52878169 15701683040
Email: sales@bjcomparison.com
Country: China
ProdList: 4678
Advantage: 58

TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7934
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 17982
Advantage: 56

More

Less

View Lastest Price from 2'',3'',5''-Triacetyl -azacytidine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2'',3'',5''-Triacetyl -azacytidine 10302-78-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

10302-78-0, 2'',3'',5''-Triacetyl -azacytidineRelated Search:

Fazarabine Azacitidine Impurity 34 L-Cytidine 1-(diaminomethylidene)-3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]urea 1,2,3,5-TETRA-O-ACETYL-BETA-L-XYLOFURANOSE Azacitidine Impurity 31 AMMELINE Azacitidine Impurity 33 5,6-dihydro-5-azacytidine Ammeline-13C3 5-Azacitidine 5'-Diphosphate (2-aminoethyl)carbamic acid Diazenecarboximidamide, N-(hydroxymethyl)-N-β-D-ribofuranosyl- 4-Amino-1-(2-O,3-O,5-O-tribenzoyl-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one β-D-Glucopyranose, 2-deoxy-2-[[[(1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidinyl)amino]thioxomethyl]amino]- Azacitidine Impurity 30 Azacitidine Impurity 41 5-Aza-2'-deoxycytidine

2'',3'',5''-Triacetyl -azacytidine

1,3,5-Triazin-2(1H)-one, 4-amino-1-(2,3,5-tri-o-acetyl-.beta.-D-ribofuranosyl)-

Nsc291930

S-Triazin-2(1H)-one, 4-amino-1-.beta.-D-ribofuranosyl-, triacetate (ester)

2',3',5'-triacetyl-5-Azacytidine

1,3,5-Triazin-2(1H)-one, 4-aMino-1-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)-

(2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(4-amino-2-oxo-1,3,5-triazin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate

Intermediate of Azacitidine

2'3'5'-triacetyl-5-Azacytosine

2',3',5'-Tri-O-Acetyl-Azacytidine

Azacitidine Triacetate

Triacetyl azacitidine

2,3,5-tri-O-acetyl-β-D-ribofuranose-4-amino-1,3,5-triazine

1,3,5-Triazin-2(1H)-one, 4-amino-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-

-O-triacetate

4-Amino-1-(2,3,5-tri-o-acetyl-beta-d-ribofuranosyl)-1,3,5-triazin-2(1h)-one

5-Azacytidine 2’,3’5’-O-triacetate

2,3,5-tri-O-acetyl-β-D-ribofuranose-4-amino-1,3,5-triazine

Azacitidine Impurity 48

10302-78-0