Overview Applications Pharmacodynamics Mode of action The relation to obesity Adverse reactions and precaution
ChemicalBook > CAS DataBase List > Testosterone propionate

Testosterone propionate

Overview Applications Pharmacodynamics Mode of action The relation to obesity Adverse reactions and precaution
Product Name
Testosterone propionate
CAS No.
57-85-2
Chemical Name
Testosterone propionate
Synonyms
Androgen;3-Oxoandrost-4-en-17-yl propionate;Pantestin;Aquaviron;Test Prop;Okasa-mascul;Orchisterone;oretonpropionate;Testosteron propionate;Recthormone testosterone
CBNumber
CB0158888
Molecular Formula
C22H32O3
Formula Weight
344.5
MOL File
57-85-2.mol
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Testosterone propionate Property

Melting point:
118-123 °C
alpha 
D25 +83 to +90° (100 mg in 10 ml dioxane)
Boiling point:
419.57°C (rough estimate)
Density 
1.0906 (rough estimate)
refractive index 
1.5000 (estimate)
storage temp. 
Store at -20°C
solubility 
ethanol: 10 mg/mL
form 
solid
color 
white
Water Solubility 
<0.1 g/100 mL at 24.5 ºC
Merck 
13,9255
BRN 
3221760
InChIKey
PDMMFKSKQVNJMI-BLQWBTBKSA-N
CAS DataBase Reference
57-85-2(CAS DataBase Reference)
NIST Chemistry Reference
Androstene-17(beta)-propionate-3-one,delta8-(57-85-2)
EPA Substance Registry System
Testosterone propionate (57-85-2)
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Safety

Hazard Codes 
T
Risk Statements 
45-22-63
Safety Statements 
53-36/37-45
RIDADR 
2811
WGK Germany 
3
RTECS 
XA3115000
HS Code 
29372900
Toxicity
LD50 oral in rat: 1gm/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H351Suspected of causing cancer

H400Very toxic to aquatic life

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T1875
Product name
Testosterone propionate
Purity
solid
Packaging
1g
Price
$29.8
Updated
2024/03/01
Sigma-Aldrich
Product number
1649007
Product name
Testosterone propionate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$506
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0001409
Product name
Testosterone propionate for system suitability
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001409
Price
$61.2
Updated
2024/03/01
Sigma-Aldrich
Product number
T1875
Product name
Testosterone propionate
Purity
solid
Packaging
5g
Price
$83.5
Updated
2024/03/01
Sigma-Aldrich
Product number
T1875
Product name
Testosterone propionate
Purity
solid
Packaging
100g
Price
$1150
Updated
2024/03/01
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Testosterone propionate Chemical Properties,Usage,Production

Overview

Testosterone propionate, sold under the brand name Testoviron among others, is an androgen and anabolic steroid(AAS) medication that is used mainly in the treatment of low testosterone levels in men. Anabolic androgenic steroids(AAS) were originally developed in the late 1930s and used since 1950s to improve athletic performance, male physical attractiveness and improves body image for both sexes[1]. Athletes use AAS to increase strength, lean body mass, and, in some cases, improve physical appearance[2]. Accordingly, AAS increase body weight, fat-free mass, muscle size and strength training in healthy men receiving 600 mg of testosterone weekly for 10 weeks[3-5]. In the absence of strength training the muscle size is increased by higher doses of AAS[3,4].

Figure 1 the chemical structure of testosterone propionate

Applications

Testosterone propionate is often used for muscle mass building. The original medical indication is for the treatment of androgen deficiency in male adults either in hypogonadism or andropaus[7]. Nowadays testosterone propionate is indicated for its use in heifers in order to stimulate maximal growth[6].
Hypogonadism(the late puberty and premature termination of adolescent growth, some types of impotence) is the most common indication for AAS therapy in men. At present, The United States Food and Drug Administration(FDA) approved clinical use of AAS for treatment of hypogonadism, anemia accompanying renal and bone marrow failure, endometriosis, cancer and wasting syndrome in human immunodeficiency virus infection[8,9]. The other clinical uses of AAS include treatment of catabolic states and cachexia(i.e chronic obstructive pulmonary disease), corticosteroid therapy, osteoporosis, growth stimulation in male puberty, prophylaxis for hereditary angioedema, hepatic disease, and female to male transsexualism, hypoplastic anemia, multiple sclerosis, sexual dysfunction and depression.
Testosterone is also available in several different pharmaceutical formulations and is recommended for use in veterinary medicine to treat chronic wasting conditions and improve appetite and physical appearance. In addition, veterinary compounding pharmacies offer for sale numerous testosterone ester preparations in oil and testosterone suspension in aqueous vehicle[10-12].

Pharmacodynamics

The administration of testosterone propionate can induce production of proteins related to male sexual development. On the other hand, testosterone itself present an estrogenic activity due to interaction with aromatase enzyme, thus the continuous administration of testosterone propionate may cause the elevation of plasma estrogen. Clinical trials showed as well, a decrease in plasma LH after testosterone propionate administration[13].

Mode of action

Anabolic steroids are thought to exert their actions by several different mechanisms. These mechanisms include modulating androgen receptor expression as a consequence of[i] intracellular metabolism and by[ii] directly affecting the topology of the androgen receptor and thus subsequent interaction with co-activators and transcriptional activity. Other mechanisms include[iii] an anticatabolic effect by interfering with glucocorticoid receptor expression; and[iv] by non-genomic, as well as by genomic pathways, in the CNS resulting in behavioural changes. These mechanisms are discussed herein. Free testosterone[T] is transported into the cytoplasm of target tissue cells, further binding to the androgen receptor, or being reduced to 5alpha-dihydrotestosterone(DHT) by the cytoplasmic enzyme 5alpha-reductase. The binding areas are called hormone response elements(HREs), and influence transcriptional activity of certain genes, producing the androgen effects.[14-16]

The relation to obesity

Several studies have demonstrated an inverse relationship between indicators of obesity(body mass index, waist circumference, a reliable indicator of visceral obesity), and testosterone levels over all age groups[15-17]. Obesity contributes to onset of type II diabetes mellitus(T2DM), dyslipidemia, hypertension and, therefore, MetS. An inverse association between the severity of features of MetS, T2DM and plasma testosterone has been previously reported[18]. In one study, this association was independent of age and body mass index[19], underlining the complexity of the relationship between testosterone and obesity[20]. This became also apparent from another study that verified the prevalence of low testosterone levels in male T2DM patients, related to variations in BMI, waist circumference, neuropathy, triglycerides, CRP, glucose, insulin and HOMAIR, but no increase of silent myocardial ischemia or peripheral arterial disease was established[21]. This is supported by other studies linking low testosterone, cardiovascular risk and insulin resistance(for review[22]). Although age is associated with the prevalence of MetS, young men with features of the MetS exhibit reduced testosterone levels[23, 24] and testosterone treatment in these individuals positively affects weight reduction, with concomitant reduction in insulin resistance(IR). The exact pathophysiological mechanisms responsible for reduced testosterone levels in obesity remain under investigation[15], however, hyperinsulinemia is shown to suppress serum testosterone levels[25]. Testosterone levels are reduced in men with T2DM, with an inverse association between testosterone levels and glycosylated hemoglobin(HbA1c)[26] and this occurs independently of medications, such as statins[27]. In men with low plasma testosterone, the likelihood of T2DM is increased and several large prospective studies have shown that low T testosterone levels predict development of T2DM in men. Low levels of testosterone are associated with a decreased lean body mass, and relative muscle mass is inversely associated with insulin resistance and prediabetes[28].

Adverse reactions and precaution

Testosterone propionate is a kind of AAS. The most common reversible side effect of AAS is cosmetic in nature. The orally used AAS may cause hepatotoxicity. However there is no report describing hepatotoxicity due to use of parenteral AAS preparations, which appear to damage heart muscles in long-term use[29]. There are several side effects of AAS use such as; headaches, gastrointestinal irritation, fluid retention in the extremities, diarrhea, stomach pains, oily skin. Additionally jaundice, menstrual abnormalities, hypertension and infections at injection site may be observed. Acne develops in both sexes at puberty during treatment with AAS due to secretion of the natural oil sebum and growth of sebaceous glands[30]. Males using high doses of AAS may have elevated circulating estrogen levels similar to women during a normal menstral cycle. This effect is result of aromatization of testosterone in part to estrogens. Therefore, gynecomastia and breast pain may be observed in men taking high doses of AAS[31].
Chronic adverse effects associated with AAS abuse include acne, urogenital problems, endocrine abnormalities, neuropsychiatric disorders, hepatic and cardiovascular diseases. Acne is common adverse effect of AAS use seen in almost 50% of the androgen uses. Acne fulminans and acne conglobata are the most common forms of acne associated with AAS[32]. Subjects using AAS should be warned that acne associated with AAS can get worse with vitamin B supplement[32]. Gynecomastia and suppression of spermatogenesis are frequent consequences of AAS use. High dose of AAS suppresses the hypothalamic-pituitary-gonadal axis due to negative feedback and, it may take weeks or months for the axis to recover. Consequently atrophy of the seminiferous tubules during this time may result in subfertility or infertility[33]. Furthermore, subjects may continue to encounter symptoms of hypogonadism[erectile dysfunction, low libido and low vitality] even after discontinuation of AAS until the axis recovers. Recent reports suggest that use of clomiphene citrate may hasten the recovery of gonadal axis[34].

Chemical Properties

Testosterone Propionate occurs as white or almost white powder or colourless to pale yellow, crystals or crystalline powder. It is freely soluble in methanol and in ethanol, and practically insoluble in water.

Uses

Testosterone propionate is an is an androgen and anabolic steroid (AAS) medication, which directs the development of the male phenotype during embryogenesis and at puberty. It has been widely used by athletes and bodybuilders for physical performance enhancement. Testosterone propionate has also been used for studying its effects on pregnant ewes.

Definition

ChEBI: Testosterone propionate is a steroid ester.

brand name

Andro heart injecta;Androfort;Androlan in oils;Cortrifosal;Durateston v;Encilcort;Galanrent;Gondrone;Gyno-terazol;Hermo m;Jeifer-old;Malogen in oil;Malotrone;Micro-sterandryl;Napionate;Orchisterone-p;Pantesin;Perandern;Pertesis;Sterotest;Sutanone;Tesrina;Testanderogen;Testenat;Testigrmon;Testilen;Testirene;Testoici;Testoidral;Testonate;Testopinate;Testo-retard;Testoviron (ampule);Testoviron-10/-25/-50;Testoviron-depot-50/-100;Testovis;Testron;Tostrina;Triomone;Vantostol-p;Viromon.

World Health Organization (WHO)

In 1982, low dosage preparations of testosterone propionate, a synthetic ester of the naturally-occurring androgen, testosterone, were prohibited in Bangladesh following their inadmissable promotion as anabolic agents for use in malnourished children. Higher dosage preparations of testosterone propionate remain available in many countries, including Bangladesh, for several highly specific but limited indications including hypogonadism and the palliative treatment of inoperable breast cancer.

General Description

Testosterone propionate appears as odorless white or yellowish-white crystals or a white or creamy-white crystalline powder. (NTP, 1992)

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Testosterone propionate is sensitive to light. Incompatible with alkalis and oxidizing agents. .

Fire Hazard

Flash point data for Testosterone propionate are not available; however, Testosterone propionate is probably combustible.

Biochem/physiol Actions

Androgens direct the development of the male phenotype during embryogenesis and at puberty. Testosterone is an androgen that is secreted by the testis. This hormone is converted to dihydrotestosterone in the target tissues where it regulates several biological functions. Testosterone propionate has been synthetically derived from a plant. This product has extended and faster-acting functions when compared to other testosterone esters.

Safety Profile

with experimental neoplastigenic, tumorigenic, and teratogenic data. Moderately toxic by ingestion and wintraperitoneal routes. Human male reproductive effects by intramuscular and parenteral routes: changes in spermatogenesis, testes, epid~dpmis, and sperm duct. Human female reproductive effects by intramuscular and parenteral routes: menstrual cycle changes or disorders and effects on ferthty. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. See also TESTOSTERONE.

Purification Methods

Crystallise the propionate from aqueous EtOH, or Et2O/pet ether (m 121o), and it has max at 240nm (EtOH), and [] 20 +114o (c 1, CHCl3). Also purify it by HPLC. [Ercol & de Ruggieri J Am Chem Soc 75 650, 652 1953, polymorphism: Brandst.tter-Kuhnert & Kofler Mickokim Acta 847, 850 1959, Beilstein 8 IV 977.]

Mode of action

Testosterone Propionate is a short acting oil-based injectable formulation of testosterone. Testosterone inhibits gonadotropin secretion from the pituitary gland and ablates estrogen production in the ovaries, thereby decreasing endogenous estrogen levels. In addition, this agent promotes the maintenance of male sex characteristics and is indicated for testosterone replacement in hypogonadal males.

Testosterone propionate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Testosterone propionate manufacturers

Shaanxi Xianhe Biotech Co., Ltd
Product
Testosterone Propionate 57-85-2
Price
US $10.00/kg
Min. Order
100kg
Purity
99%
Supply Ability
1000 kg
Release date
2024-09-04
Apeloa production Co.,Limited
Product
Testosterone propionate 57-85-2
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
1000
Release date
2024-05-22
hebei hongtan Biotechnology Co., Ltd
Product
testosterone propionate 57-85-2
Price
US $30.00-10.00/kg
Min. Order
1kg
Purity
99.98%
Supply Ability
20tons
Release date
2024-05-11

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