2,5-Dibromo-3-methylpyridine

Uses

Product Name: 2,5-Dibromo-3-methylpyridine
CAS No.: 3430-18-0
Chemical Name: 2,5-Dibromo-3-methylpyridine
Synonyms: TIMTEC-BB SBB003143;2,5-Dibromo-3-methyl;2,5-DIBROMO-3-PICOLINE;2,5-Dibromo-3-picoline,98%;2,5-DIBROMO-3-METHYLPYRIDINE;2-CHLORO-5-HYDROXY-3-PICOLINE;2,5-Di BroMo-3-Methyl Pyridnie;2,5-Dibromo-3-methylpyridine>Pyridine, 2,5-dibromo-3-methyl-;2,5-DibroMo-3-Methylpyridine, 97%, 97%
CBNumber: CB0172392
Molecular Formula: C6H5Br2N
Formula Weight: 250.92
MOL File: 3430-18-0.mol

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2,5-Dibromo-3-methylpyridine Property

Melting point:: 43-47 °C (lit.)
Boiling point:: 114 °C / 6mmHg
Density: 1.9318 (rough estimate)
refractive index: 1.6300 (estimate)
Flash point:: >230 °F
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: soluble in Methanol
pka: -1.27±0.20(Predicted)
form: Crystalline Powder
color: Off-white to beige
InChI: InChI=1S/C6H5Br2N/c1-4-2-5(7)3-9-6(4)8/h2-3H,1H3
InChIKey: LIMXEVCFAUTBCK-UHFFFAOYSA-N
SMILES: C1(Br)=NC=C(Br)C=C1C
CAS DataBase Reference: 3430-18-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/38-36/37/38-20/21/22
Safety Statements: 26-36/37/39-36
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
HazardClass: 6.1
PackingGroup: III
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 637661
Product name: 2,5-Dibromo-3-methylpyridine
Purity: 98%
Packaging: 1g
Price: $28
Updated: 2023/06/20

Sigma-Aldrich

Product number: 637661
Product name: 2,5-Dibromo-3-methylpyridine
Purity: 98%
Packaging: 5g
Price: $82.8
Updated: 2023/01/07

TCI Chemical

Product number: D3455
Product name: 2,5-Dibromo-3-methylpyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $16
Updated: 2025/07/31

TCI Chemical

Product number: D3455
Product name: 2,5-Dibromo-3-methylpyridine
Purity: >98.0%(GC)
Packaging: 25g
Price: $48
Updated: 2025/07/31

TRC

Product number: D425915
Product name: 2,5-Dibromo-3-methylpyridine
Packaging: 1g
Price: $55
Updated: 2021/12/16

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2,5-Dibromo-3-methylpyridine Chemical Properties,Usage,Production

Uses

2,5-Dibromo-3-methylpyridine is a pyridine organic compound, mainly used as a pharmaceutical intermediate.

Chemical Properties

Off-white to beige crystalline powder

Synthesis

3430-21-5

3430-18-0

General procedure for the synthesis of 2,5-dibromo-3-methylpyridine (49) from 2-amino-3-methyl-5-bromopyridine (48, 69 g, 0.37 mol): the raw material was suspended in hydrobromic acid (200 mL, 48% aqueous solution) and cooled to -15 °C. The reaction was carried out in aqueous solution of sodium nitrite (100 mL). Bromine (95 g, 0.59 mol) was slowly added dropwise, followed by an aqueous solution (100 mL) of sodium nitrite (69 g, 1 mol), while keeping the temperature of the reaction mixture below -15 °C. The reaction mixture was then cooled to -15 °C. After completion of the dropwise addition, the cooling bath was removed and the reaction mixture was stirred for 3 hours at room temperature. The reaction was cooled again to -15 °C and quenched with an aqueous solution (500 mL) of potassium hydroxide (112 g, 2 mol). After removing the cooling bath, stirring was continued for 1.5 hours. The product was extracted with ethyl acetate (3 x 300 mL), the organic phases were combined, washed sequentially with water (2 x 200 mL), saturated aqueous sodium bicarbonate (200 mL), dried over sodium sulfate and concentrated to dryness under reduced pressure. The oily residue was dissolved in chloroform (100 mL), filtered through a silica gel pad and washed with chloroform. The filtrates were combined and evaporated under reduced pressure to give the light yellow solid product 49 (87 g, 94%) with a melting point of 38-40 °C (literature value: 41-42 °C). The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3) δ 8.22 (d, J = 2.4 Hz, 1H), 7.61 (d, J = 2.4 Hz, 1H), 2.33 (s, 3H); 13C NMR (75 MHz, CDCl3) δ 148.29, 143.05, 141.15, 137.15, 119.68, 22.06 Confirmed.

References

[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 4, p. 1682 - 1697
[2] Patent: US2014/18360, 2014, A1. Location in patent: Paragraph 0175
[3] Patent: CN105348177, 2016, A. Location in patent: Paragraph 0012; 0017
[4] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001, vol. 40, # 11, p. 1129 - 1131
[5] Journal of Medicinal Chemistry, 2007, vol. 50, # 15, p. 3730 - 3742

2,5-Dibromo-3-methylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products

5-Bromo-2-iodo-3-methylpyridine 2-BROMO-3-METHYLPYRIDINE-5-BORONIC ACID 5-BROMO-3-METHYL-2-PYRIDINECARBALDEHYDE

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2,5-Dibromo-3-methylpyridine Suppliers

Americas 1 Belgium 2 China 306 Europe 4 France 2 Germany 6 India 35 Japan 4 Switzerland 3 The Netherlands 2 Ukraine 1 United Kingdom 17 United States 55 Global 438

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View Lastest Price from 2,5-Dibromo-3-methylpyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2,5-Dibromo-3-methylpyridine 3430-18-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-06-03

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2,5-Dibromo-3-methylpyridine 3430-18-0
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-18

Henan Aochuang Chemical Co.,Ltd.

Product: 2,5-Dibromo-3-methylpyridine 3430-18-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-12

3430-18-0, 2,5-Dibromo-3-methylpyridineRelated Search:

2,5-Dibromo-3-nitropyridine Ferric nitrate 2,5-DIBROMO-6-METHYLPYRIDINE 2,5-DIBROMO-4-METHYLPYRIDINE 2,5-DIBROMONICOTINALDEHYDE 2,5-DIBROMONICOTINIC ACID 2,5,6-Tribromo-3-methylpyridine 2-AMINO-3,5-DIBROMO-6-METHYLPYRIDINE 3,5-DIBROMO-4-METHYLPYRIDINE 2,5-Dibromo-3-methylpyridine 2,3-DIBROMO-5-METHYLPYRIDINE 2,3-DIBROMO-6-METHYLPYRIDINE 4-AMINO-3,5-DIBROMO-2-METHYLPYRIDINE,4-AMINO-3,5-DIBROMO-6-METHYLPYRIDINE 2,5-Dibromopyridine 3-Picoline Bromine 3,5-DIBROMO-2-METHYLPYRIDINE 2,5-DIMETHYL-3,6-DIBROMOPYRIDINE

2,5-DIBROMO-3-METHYLPYRIDINE

2,5-DIBROMO-3-PICOLINE

TIMTEC-BB SBB003143

2,5-DIBROMO-3-METHYLPYRIDINE, PURISS, 98%

2-CHLORO-5-HYDROXY-3-PICOLINE

2,5-Dibromo-3-picoline,98%

2,5-Dibromo-3-methyl

2,5-Di BroMo-3-Methyl Pyridnie

2,5-DibroMo-3-Methylpyridine, 97%, 97%

Pyridine, 2,5-dibromo-3-methyl-

2,5-Dibromo-3-methylpyridine&gt

2,5-Dibromo-3-methylpyridine ISO 9001：2015 REACH

3430-18-0

33430-18-0

3434-18-0

C6H5Br2N

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyridines

Building Blocks

Halopyridines

Boronic Acid

C6Heterocyclic Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyridine

Pyridines, Pyrimidines, Purines and Pteredines

Halides

Pyridines

Bromopyridines