2,5-Dibromo-4-methylpyridine

Uses

Product Name: 2,5-Dibromo-4-methylpyridine
CAS No.: 3430-26-0
Chemical Name: 2,5-Dibromo-4-methylpyridine
Synonyms: TIMTEC-BB SBB003142;2,5-Dibromo-4-methyL;2,5-DIBROMO-4-PICOLINE;3-Chloro-3-iodopyridine;2,5-Dibromo-4-picoline,98%;2,3-dibromo-4-methylpyridine;2,5-DIBROMO-4-METHYLPYRIDINE;Pyridine, 2,5-dibromo-4-methyl-;2,5-Dibromo-4-methylpyridine >2,5-Dibromo-4-methylpyridine, 97%
CBNumber: CB6140119
Molecular Formula: C6H5Br2N
Formula Weight: 250.92
MOL File: 3430-26-0.mol

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2,5-Dibromo-4-methylpyridine Property

Melting point:: 37-42 °C
Boiling point:: 181.5°C (rough estimate)
Density: 1.9318 (rough estimate)
refractive index: 1.6300 (estimate)
Flash point:: 113°
storage temp.: Inert atmosphere,Room Temperature
solubility: soluble in Methanol
pka: -0.91±0.18(Predicted)
form: Low Melting Solid
color: Light yellow to orange
InChI: InChI=1S/C6H5Br2N/c1-4-2-6(8)9-3-5(4)7/h2-3H,1H3
InChIKey: WWJLJUAHQHXDGM-UHFFFAOYSA-N
SMILES: C1(Br)=NC=C(Br)C(C)=C1
CAS DataBase Reference: 3430-26-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 36/37/38-20/21/22-41-37/38-22
Safety Statements: 36/37/39-26-39
WGK Germany: 3
Hazard Note: Harmful
HazardClass: IRRITANT
HS Code: 29333999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 708143
Product name: 2,5-Dibromo-4-methylpyridine
Purity: 97%
Packaging: 1g
Price: $64.7
Updated: 2023/06/20

TCI Chemical

Product number: D4058
Product name: 2,5-Dibromo-4-methylpyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $27
Updated: 2025/07/31

TCI Chemical

Product number: D4058
Product name: 2,5-Dibromo-4-methylpyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $69
Updated: 2025/07/31

TRC

Product number: D425918
Product name: 2,5-Dibromo-4-methylpyridine
Packaging: 500mg
Price: $65
Updated: 2021/12/16

TRC

Product number: D425918
Product name: 2,5-Dibromo-4-methylpyridine
Packaging: 100mg
Price: $45
Updated: 2021/12/16

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2,5-Dibromo-4-methylpyridine Chemical Properties,Usage,Production

Uses

2,5-Dibromo-4-methylpyridine is mainly used in organic synthesis, and in the pharmaceutical industry, it is used to synthesize heart disease drugs such as disopyramide (disopyramide phosphate). Disopyramide is used to maintain sinus rhythm in atrial fibrillation and atrial flutter, or to prevent the recurrence of ventricular tachycardia and ventricular fibrillation. It can also be used for premature atrial contractions, paroxysmal atrial tachycardia, premature ventricular contractions, etc.

Chemical Properties

Light yellow to orange low melting solid

Synthesis

98198-48-2

3430-26-0

General procedure for the synthesis of 2,5-dibromo-4-methylpyridine from 2-amino-5-bromo-4-methylpyridine: 2-amino-5-bromo-4-methylpyridine (2.0 g, 10.7 mmol) was dissolved in 48% aqueous hydrobromic acid (14 mL, 123 mmol) and cooled to 2 °C in a salt/ice bath. Bromine (1.65 mL, 32.1 mmol) was added dropwise while keeping the internal temperature below 2 °C. Subsequently, a solution of sodium nitrite (3.69 g, 53.5 mmol) in water (5 mL) was added, keeping the internal temperature below 5 °C and the reaction mixture was stirred between 0 °C and 5 °C for 1 hour. The pH of the reaction mixture was adjusted to about 13 by slowly adding and cooling a 50% aqueous sodium hydroxide solution. after warming the reaction mixture to room temperature, it was extracted with ether. The organic phases were combined, dried with anhydrous magnesium sulfate and concentrated to give a brown oil. Purification by fast column chromatography on silica gel, using 5% ether/hexane as eluent, afforded the target product 2,5-dibromo-4-methylpyridine as a white solid (1.83 g, 7.29 mmol, 68% yield). Mass spectrometry analysis showed the [M + H]+ peak to be 251.9; the retention time (tR) was 2.3 min (Method 1).

References

[1] Patent: WO2008/124610, 2008, A1. Location in patent: Page/Page column 46
[2] Patent: WO2008/124614, 2008, A1. Location in patent: Page/Page column 38-39

2,5-Dibromo-4-methylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2,5-Dibromo-4-methylpyridine Suppliers

Americas 1 Belgium 2 China 286 Europe 3 France 2 Germany 6 India 26 Japan 2 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 6 United States 43 Global 381

Shanghai EachChem Co., Ltd.

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View Lastest Price from 2,5-Dibromo-4-methylpyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2,5-Dibromo-4-methylpyridine 3430-26-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-29

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2,5-Dibromo-4-methylpyridine 3430-26-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-09

Henan Aochuang Chemical Co.,Ltd.

Product: 2,5-Dibromo-4-methylpyridine 3430-26-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-29

3430-26-0, 2,5-Dibromo-4-methylpyridineRelated Search:

2,5-DIBROMO-3-METHYLPYRIDINE,2,5-DIBROMO-3-METHYLPYRIDINE, PURISS, 98% 2,5-Dibromo-6-methylpyridine 98%,2,5-DIBROMO-6-METHYLPYRIDINE,2,5-Dibromo-6-methylpyridine98% 2,5-Dibromo-3-nitropyridine 3,5-Dibromo-2-methylpyridine 4-AMINO-3,5-DIBROMO-2-METHYLPYRIDINE,4-AMINO-3,5-DIBROMO-6-METHYLPYRIDINE 2,6-Dibromopyridine-4-carboxylic acid 2,5-Dibromo-4-methylpyridine 2-Chloro-3,5-dibromo-4-methylpyridine 2,3-DIBROMO-6-METHYLPYRIDINE 2,3-DIBROMO-5-METHYLPYRIDINE 98%,2,3-DIBROMO-5-METHYLPYRIDINE 2-fluoro-3，5-dibromo-4-methylpyridine 2-AMINO-3,5-DIBROMO-6-METHYLPYRIDINE,2-AMINO-3,5-DIBROMO-6-METHYLPYRIDINE 97%,2-AMINO-3,5-DIBROMO-6-METHYLPYRIDINE, 97,2-Amino-3,5-dibromo-6-methylpyridine ,98% 2-Amino-3,5-dibromo-4-methylpyridine 3,5-DIBROMO-4-METHYLPYRIDINE 2,5-Dibromopyridine-4-carboxaldehyde 2,5-Dibromo-4-(trifluoromethyl)pyridine 2,5-Dibromo-4-methyl-3-nitropyridine 2,3,5-TRIBROMO-4-METHYLPYRIDINE

TIMTEC-BB SBB003142

2,5-DIBROMO-4-METHYLPYRIDINE

2,5-DIBROMO-4-PICOLINE

2,3-dibromo-4-methylpyridine

2,5-Dibromo-4-picoline,98%

2,5-Dibromo-4-methylpyridine &gt

2,5-Dibromo-4-methyL

Pyridine, 2,5-dibromo-4-methyl-

3-Chloro-3-iodopyridine

2,5-Dibromo-4-methylpyridine ISO 9001：2015 REACH

2,5-Dibromo-4-methylpyridine, 97%

2,5-Dibromo-4-methylpyridine, CAS 3430-26-0

3430-26-0

3430-26-2

C6H5NBr2

Brominated heterocyclic series

Boronic Acid

Pyridine Series

Halides

blocks

Bromides

Pyridines

Pyridine

bc0001