2,6-Dibromopyridine-4-carboxylic acid
- Product Name
- 2,6-Dibromopyridine-4-carboxylic acid
- CAS No.
- 2016-99-1
- Chemical Name
- 2,6-Dibromopyridine-4-carboxylic acid
- Synonyms
- 2,6-Dibromoisonicotinic acid;2,6-DibroMopyridine-4-car...;2,6-Dibromopyridine-4-carboxylic;DibroMopyridine-4-carboxylic acid;2,6-DibroMoisonicotinic acid, 95+%;2,6-Dibromopyridine-4-carboxylicaci;6-Dibromopyridine-4-carboxylic acid;2,6-Dibromo-4-pyridinecarboxylic acid;2,6-Dibromopyridine-4-carboxylic acid;2,6-Dibromoopyridine-4-carboxylic acid
- CBNumber
- CB3948136
- Molecular Formula
- C6H3Br2NO2
- Formula Weight
- 280.9
- MOL File
- 2016-99-1.mol
2,6-Dibromopyridine-4-carboxylic acid Property
- Melting point:
- 184-185 °C(Solv: water (7732-18-5))
- Boiling point:
- 487.5±45.0 °C(Predicted)
- Density
- 2.202±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 2.59±0.10(Predicted)
- color
- White to off white
- InChI
- InChI=1S/C6H3Br2NO2/c7-4-1-3(6(10)11)2-5(8)9-4/h1-2H,(H,10,11)
- InChIKey
- AULQTVXAKNKCCA-UHFFFAOYSA-N
- SMILES
- C1(Br)=NC(Br)=CC(C(O)=O)=C1
Safety
- Hazard Codes
- Xi
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- D425955
- Product name
- 2,6-Dibromopyridine-4-carboxylicAcid
- Packaging
- 250mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 072759
- Product name
- 2,6-Dibromoisonicotinic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $29
- Updated
- 2021/12/16
- Product number
- OR2261
- Product name
- 2,6-Dibromoisonicotinicacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $31
- Updated
- 2021/12/16
- Product number
- 4H21-9-X5
- Product name
- 2,6-Dibromoisonicotinic acid
- Packaging
- 1g
- Price
- $36
- Updated
- 2021/12/16
- Product number
- OR2261
- Product name
- 2,6-Dibromoisonicotinicacid
- Purity
- 95%
- Packaging
- 250mg
- Price
- $15
- Updated
- 2021/12/16
2,6-Dibromopyridine-4-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
Pale yellow solid
Uses
2,?6-?Dibromopyridine-?4-?carboxylic Acid is an analog of 2,6-Dichloroisonicotinic acid which binds and inhibits tobacco catalase activity.
Synthesis
99-11-6
2016-99-1
General procedure for the synthesis of 2,6-dibromopyridine-4-carboxylic acid from citrazinic acid: Citrazinic acid (2.33 g, 0.015 mol) was mixed with phosphorus tribromide and heated to 180 °C under nitrogen protection for 3 hours. After completion of the reaction, the reaction mixture was cooled and quenched carefully with ice water. The reaction mixture was filtered and the aqueous phase was extracted with dichloromethane (4 x 40 ml). The solid fraction was continuously extracted in a Soxhlet extractor using dichloromethane for 12 hours. The directly extracted organic phase was dried with anhydrous sodium sulfate, filtered and concentrated to give 2.2 g of slightly red solid. The organic phase of Soxhlet extraction was similarly dried with anhydrous sodium sulfate, filtered and concentrated to give 0.5 g of a slightly red solid. The two fractions of 2,6-dibromoisonicotinic acid (64% total yield) were combined after confirmation of structural identity by NMR hydrogen spectroscopy (CDCl3, δ 8.04, 2H, s).
References
[1] Journal of Medicinal Chemistry, 2013, vol. 56, # 12, p. 5079 - 5093
[2] Tetrahedron, 2007, vol. 63, # 2, p. 291 - 298
[3] Organic and Biomolecular Chemistry, 2005, vol. 3, # 8, p. 1460 - 1467
[4] Patent: WO2005/84439, 2005, A1. Location in patent: Page/Page column 35
[5] Synthesis, 2000, # 8, p. 1138 - 1142
2,6-Dibromopyridine-4-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-Dibromopyridine-4-carboxylic acid manufacturers
- Product
- 2,6-Dibromopyridine-4-carboxylic acid 2016-99-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-18
- Product
- 2,6-Dibromopyridine-4-carboxylic acid 2016-99-1
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-12
- Product
- 2,6-Dibromopyridine-4-carboxylic acid 2016-99-1
- Price
- US $1.00/KG
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 200kgs
- Release date
- 2020-01-09