Methyl 2,6-dibromopyridine-4-carboxylate
- Product Name
- Methyl 2,6-dibromopyridine-4-carboxylate
- CAS No.
- 119308-57-5
- Chemical Name
- Methyl 2,6-dibromopyridine-4-carboxylate
- Synonyms
- 6-dibroMopyridine-4-carboxylate;Methyl 2,6-dibromoisonicotinate;Methyl 2,6-dibromopyridine-4-carboxylate;2,6-Dibromo Pyridine 4-Carboxylic acid methyl ester;4-Pyridinecarboxylic acid, 2,6-dibroMo-, Methyl ester;Methyl 2,6-dibromopyridine-4-carboxylate, 2,6-Dibromo-4-(methoxycarbonyl)pyridine
- CBNumber
- CB02130932
- Molecular Formula
- C7H5Br2NO2
- Formula Weight
- 294.93
- MOL File
- 119308-57-5.mol
Methyl 2,6-dibromopyridine-4-carboxylate Property
- Melting point:
- 86.8-88.2 °C(Solv: hexane (110-54-3))
- Boiling point:
- 320.9±37.0 °C(Predicted)
- Density
- 1.928±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -5.78±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- M301195
- Product name
- Methyl2,6-dibromopyridine-4-carboxylate
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 3404CY
- Product name
- Methyl2,6-dibromopyridine-4-carboxylate
- Packaging
- 1g
- Price
- $114
- Updated
- 2021/12/16
- Product number
- CS-0049187
- Product name
- Methyl2,6-dibromoisonicotinate
- Packaging
- 5g
- Price
- $134
- Updated
- 2021/12/16
- Product number
- OR18036
- Product name
- Methyl 2,6-dibromoisonicotinate
- Packaging
- 1g
- Price
- $149
- Updated
- 2021/12/16
- Product number
- 4H23-9-X9
- Product name
- Methyl 2,6-dibromoisonicotinate
- Packaging
- 1g
- Price
- $176
- Updated
- 2021/12/16
Methyl 2,6-dibromopyridine-4-carboxylate Chemical Properties,Usage,Production
Uses
Methyl 2,6-dibromopyridine-4-carboxylate can be used as organic synthesis intermediate or pharmaceutical intermediate. It can also be used to prepare nanostructured coating materials.
Synthesis
67-56-1
99-11-6
119308-57-5
General procedure for the synthesis of methyl 2,6-dibromoisonicotinate from methanol and citrazinic acid: citrazinic acid (5.0 g, 32.2 mmol) was mixed with phosphorus tribromide (POBr3, 27.5 g, 96.8 mmol) and the reaction was heated at 130 °C. Upon completion of the reaction, the reaction mixture was cooled to 0 °C and methanol (250 mL) was slowly added to quench the reaction. Subsequently, the mixture was concentrated under reduced pressure and later separated by extraction with dichloromethane and saturated sodium bicarbonate solution. The aqueous layer was washed with saturated sodium bicarbonate solution. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a brown solid product. The product was analyzed by nuclear magnetic resonance (NMR) and liquid chromatography-mass spectrometry (LCMS) to confirm that the purity was sufficient for the subsequent reaction (79% yield, 7.5 g). Mass spectrometry (ESI) m/z: 295.8 (M+1). 1H NMR (400 MHz, CD2Cl2) δppm: 8.10 (s, 2H), 4.05 (s, 3H).
References
[1] Journal of Medicinal Chemistry, 2010, vol. 53, # 15, p. 5422 - 5438
[2] Patent: WO2009/150230, 2009, A1. Location in patent: Page/Page column 65
[3] European Journal of Inorganic Chemistry, 2010, # 13, p. 1913 - 1928
[4] Journal of Organic Chemistry, 2006, vol. 71, # 12, p. 4696 - 4699
[5] Synthesis, 2008, # 17, p. 2764 - 2770
Methyl 2,6-dibromopyridine-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 2,6-dibromopyridine-4-carboxylate manufacturers
- Product
- Methyl 2,6-dibromopyridine-4-carboxylate 119308-57-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-23