ChemicalBook > CAS DataBase List > 2,6-Dibromopyridine-4-carboxylic acid

2,6-Dibromopyridine-4-carboxylic acid

Product Name
2,6-Dibromopyridine-4-carboxylic acid
CAS No.
2016-99-1
Chemical Name
2,6-Dibromopyridine-4-carboxylic acid
Synonyms
2,6-Dibromoisonicotinic acid;2,6-DibroMopyridine-4-car...;2,6-Dibromopyridine-4-carboxylic;DibroMopyridine-4-carboxylic acid;2,6-DibroMoisonicotinic acid, 95+%;2,6-Dibromopyridine-4-carboxylicaci;6-Dibromopyridine-4-carboxylic acid;2,6-Dibromo-4-pyridinecarboxylic acid;2,6-Dibromopyridine-4-carboxylic acid;2,6-Dibromoopyridine-4-carboxylic acid
CBNumber
CB3948136
Molecular Formula
C6H3Br2NO2
Formula Weight
280.9
MOL File
2016-99-1.mol
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2,6-Dibromopyridine-4-carboxylic acid Property

Melting point:
184-185 °C(Solv: water (7732-18-5))
Boiling point:
487.5±45.0 °C(Predicted)
Density 
2.202±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
pka
2.59±0.10(Predicted)
color 
White to off white
InChI
InChI=1S/C6H3Br2NO2/c7-4-1-3(6(10)11)2-5(8)9-4/h1-2H,(H,10,11)
InChIKey
AULQTVXAKNKCCA-UHFFFAOYSA-N
SMILES
C1(Br)=NC(Br)=CC(C(O)=O)=C1
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Safety

Hazard Codes 
Xi
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
D425955
Product name
2,​6-​Dibromopyridine-​4-​carboxylicAcid
Packaging
250mg
Price
$65
Updated
2021/12/16
Apolloscientific
Product number
OR2261
Product name
2,6-Dibromoisonicotinicacid
Purity
95%
Packaging
250mg
Price
$15
Updated
2021/12/16
SynQuest Laboratories
Product number
4H21-9-X5
Product name
2,6-Dibromoisonicotinic acid
Packaging
250mg
Price
$20
Updated
2021/12/16
Matrix Scientific
Product number
072759
Product name
2,6-Dibromoisonicotinic acid
Purity
95+%
Packaging
1g
Price
$29
Updated
2021/12/16
Apolloscientific
Product number
OR2261
Product name
2,6-Dibromoisonicotinicacid
Purity
95%
Packaging
1g
Price
$31
Updated
2021/12/16
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2,6-Dibromopyridine-4-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

Pale yellow solid

Uses

2,?6-?Dibromopyridine-?4-?carboxylic Acid is an analog of 2,6-Dichloroisonicotinic acid which binds and inhibits tobacco catalase activity.

Synthesis

99-11-6

2016-99-1

General procedure for the synthesis of 2,6-dibromopyridine-4-carboxylic acid from citrazinic acid: Citrazinic acid (2.33 g, 0.015 mol) was mixed with phosphorus tribromide and heated to 180 °C under nitrogen protection for 3 hours. After completion of the reaction, the reaction mixture was cooled and quenched carefully with ice water. The reaction mixture was filtered and the aqueous phase was extracted with dichloromethane (4 x 40 ml). The solid fraction was continuously extracted in a Soxhlet extractor using dichloromethane for 12 hours. The directly extracted organic phase was dried with anhydrous sodium sulfate, filtered and concentrated to give 2.2 g of slightly red solid. The organic phase of Soxhlet extraction was similarly dried with anhydrous sodium sulfate, filtered and concentrated to give 0.5 g of a slightly red solid. The two fractions of 2,6-dibromoisonicotinic acid (64% total yield) were combined after confirmation of structural identity by NMR hydrogen spectroscopy (CDCl3, δ 8.04, 2H, s).

References

[1] Journal of Medicinal Chemistry, 2013, vol. 56, # 12, p. 5079 - 5093
[2] Tetrahedron, 2007, vol. 63, # 2, p. 291 - 298
[3] Organic and Biomolecular Chemistry, 2005, vol. 3, # 8, p. 1460 - 1467
[4] Patent: WO2005/84439, 2005, A1. Location in patent: Page/Page column 35
[5] Synthesis, 2000, # 8, p. 1138 - 1142

2,6-Dibromopyridine-4-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,6-Dibromopyridine-4-carboxylic acid manufacturers

Dideu Industries Group Limited
Product
2,6-Dibromopyridine-4-carboxylic acid 2016-99-1
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-08-18
Shaanxi Dideu Medichem Co. Ltd
Product
2,6-Dibromopyridine-4-carboxylic acid 2016-99-1
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-12
Career Henan Chemical Co
Product
2,6-Dibromopyridine-4-carboxylic acid 2016-99-1
Price
US $1.00/KG
Min. Order
1g
Purity
98%
Supply Ability
200kgs
Release date
2020-01-09

2016-99-1, 2,6-Dibromopyridine-4-carboxylic acidRelated Search:

1,3-Dibromo-5,5-dimethylhydantoin 2,2-Bis(bromomethyl)propane-1,3-diol Chromium picolinate 2,6-Lutidine 2,4-DIBROMOBIPHENYL 2,5-PYRIDINEDICARBOXYLIC ACID 3,5-Dibromopyridine Isonicotinic acid Quinolinic acid 2,6-Dibromopyridine 1,2-Dibromopropane 2,6-Dichloroisonicotinic acid 2,6-DIBROMO-3,5-DIFLUOROISONICOTINIC ACID 5,6-DIBROMOPYRIDINE-3-CARBOXYLIC ACID Methyl 2,6-dibromopyridine-4-carboxylate Ethyl 2,6-dibromopyridine-4-carboxylate 2,6-Dibromopyridine-4-carboxylic acid CARBOXYLIC ACID

  • 2,6-Dibromoisonicotinic acid
  • 2,6-Dibromo-4-pyridinecarboxylic acid
  • 2,6-Dibromoopyridine-4-carboxylic acid
  • 2,6-Dibromopyridine-4-carboxylic acid
  • Isonicotinicacid, 2,6-dibromo- (6CI,7CI,8CI)
  • 2,6-DibroMopyridine-4-car...
  • DibroMopyridine-4-carboxylic acid
  • 2,6-Dibromopyridine-4-carboxylic acid, 4-Carboxy-2,6-dibromopyridine
  • 2,6-DibroMoisonicotinic acid, 95+%
  • 2,6-Dibromopyridine-4-carboxylic
  • 4-Pyridinecarboxylic acid, 2,6-dibromo-
  • 2,6-Dibromopyridine-4-carboxylicaci
  • 2,6-Dibromopyridine-4-carboxylic acid ISO 9001：2015 REACH
  • 6-Dibromopyridine-4-carboxylic acid
  • 2016-99-1
  • Pyridines
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