Ethyl 3,4-dihydroxybenzoate
- Product Name
- Ethyl 3,4-dihydroxybenzoate
- CAS No.
- 3943-89-3
- Chemical Name
- Ethyl 3,4-dihydroxybenzoate
- Synonyms
- ETHYL PROTOCATECHUATE;PROTOCATECHUIC ACID ETHYL ESTER;3,4-DIHYDROXYBENZOIC ACID ETHYL ESTER;EDHB;NSC 86130;NSC 619681;3,4-2-ethyl;ERLOTINIBINT-A;RARECHEM AL BI 0069;Ethyl 3,4-dihydroxyb
- CBNumber
- CB0175010
- Molecular Formula
- C9H10O4
- Formula Weight
- 182.17
- MOL File
- 3943-89-3.mol
Ethyl 3,4-dihydroxybenzoate Property
- Melting point:
- 132-134 °C(lit.)
- Boiling point:
- 275.56°C (rough estimate)
- Density
- 1.2481 (rough estimate)
- vapor pressure
- 0-9.4Pa at 20-120℃
- refractive index
- 1.4500 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Crystalline Powder
- pka
- 8.19±0.18(Predicted)
- color
- Pale yellow to beige
- Odor
- at 100.00?%. phenolic
- Water Solubility
- Insoluble in water. Soluble in ethanol.
- BRN
- 2097435
- InChIKey
- KBPUBCVJHFXPOC-UHFFFAOYSA-N
- LogP
- 1.4 at 35℃ and pH6.6
- Surface tension
- 74.7mN/m at 1g/L and 20℃
- CAS DataBase Reference
- 3943-89-3(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzoic acid, 3,4-dihydroxy-, ethyl ester(3943-89-3)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29053990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E24859
- Product name
- Protocatechuic acid ethyl ester
- Purity
- 97%
- Packaging
- 5g
- Price
- $43.8
- Updated
- 2024/03/01
- Product number
- D0571
- Product name
- Ethyl 3,4-Dihydroxybenzoate
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $26
- Updated
- 2024/03/01
- Product number
- D0571
- Product name
- Ethyl 3,4-Dihydroxybenzoate
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $64
- Updated
- 2024/03/01
- Product number
- A11001
- Product name
- Ethyl 3,4-dihydroxybenzoate, 98%
- Packaging
- 10g
- Price
- $41.65
- Updated
- 2024/03/01
- Product number
- A11001
- Product name
- Ethyl 3,4-dihydroxybenzoate, 98%
- Packaging
- 50g
- Price
- $165.65
- Updated
- 2024/03/01
Ethyl 3,4-dihydroxybenzoate Chemical Properties,Usage,Production
Description
Ethyl 3,4-dihydroxybenzoate (EDHB) is an analogue of 2-oxoglutarate and thus a competitive inhibitor of prolyl hydroxylase domain enzymes (PHDs). It is known as protocatechuic acid and is present in plant foods such as olives, roselle, du-zhong, and white grape wine.This compound have antioxidant, cardioprotective, neuroprotective, antimicrobial, anti-inflammatory and myoprotective activity, as well as anti-ulcer activity[1].
Chemical Properties
pale yellow to beige crystalline powder
Uses
An antioxidant compound found in Sicilian virgin olive oils and red wines.
Uses
The compound is a prolyl 4-hydroxylase inhibitor and can be used to protect the myocardium.
Definition
ChEBI: An ethyl ester resulting from the formal condensation of the carboxy group of 3,4-dihydroxybenzoic acid with ethanol. It is the anti-oxidative component of peanut seed testa.
Biological Activity
Ethyl 3,4-dihydroxybenzoate (EDHB) contains reducible polyphenol hydroxyl groups and exhibits antioxidant activity. Recent studies have shown that EDHB acts as an analog of the substrate α-ketoglutarate and competes for prolyl-hydroxylase activity, thus acting as an inhibitor and effectively inhibiting collagen synthesis and breast cancer metastasis. In addition, in vitro and animal studies in a cerebral ischemic rat model have revealed that EDHB shows increased protective effects and improves rat behavior by inhibiting free radical damage[2].
References
[1] Charu Nimker. "Ethyl 3,4-dihydroxy benzoate, a unique preconditioning agent for alleviating hypoxia-mediated oxidative damage in L6 myoblasts cells." Journal of Physiological Sciences 65 1 (2015): 77–87.
[2] Bo Han. "A prolyl-hydroxylase inhibitor, ethyl-3,4-dihydroxybenzoate, induces cell autophagy and apoptosis in esophageal squamous cell carcinoma cells via up-regulation of BNIP3 and N-myc downstream-regulated gene-1." PLoS ONE (2014): e107204.
Ethyl 3,4-dihydroxybenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl 3,4-dihydroxybenzoate Suppliers
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- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
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- Europe
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View Lastest Price from Ethyl 3,4-dihydroxybenzoate manufacturers
- Product
- Ethyl 3,4-dihydroxybenzoate 3943-89-3
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-11-20
- Product
- Ethyl 3,4-dihydroxybenzoate 3943-89-3
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-18
- Product
- Ethyl 3,4-dihydroxybenzoate 3943-89-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-31