Ethyl 3,4-dihydroxybenzoate

Product Name: Ethyl 3,4-dihydroxybenzoate
CAS No.: 3943-89-3
Chemical Name: Ethyl 3,4-dihydroxybenzoate
Synonyms: ETHYL PROTOCATECHUATE;PROTOCATECHUIC ACID ETHYL ESTER;3,4-DIHYDROXYBENZOIC ACID ETHYL ESTER;EDHB;NSC 86130;NSC 619681;3,4-2-ethyl;ERLOTINIBINT-A;RARECHEM AL BI 0069;Ethyl 3,4-dihydroxyb
CBNumber: CB0175010
Molecular Formula: C9H10O4
Formula Weight: 182.17
MOL File: 3943-89-3.mol

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Ethyl 3,4-dihydroxybenzoate Property

Melting point:: 132-134 °C(lit.)
Boiling point:: 275.56°C (rough estimate)
Density: 1.2481 (rough estimate)
vapor pressure: 0-9.4Pa at 20-120℃
refractive index: 1.4500 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Crystalline Powder
pka: 8.19±0.18(Predicted)
color: Pale yellow to beige
Odor: at 100.00?%. phenolic
Water Solubility: Insoluble in water. Soluble in ethanol.
BRN: 2097435
InChIKey: KBPUBCVJHFXPOC-UHFFFAOYSA-N
LogP: 1.4 at 35℃ and pH6.6
Surface tension: 74.7mN/m at 1g/L and 20℃
CAS DataBase Reference: 3943-89-3(CAS DataBase Reference)
NIST Chemistry Reference: Benzoic acid, 3,4-dihydroxy-, ethyl ester(3943-89-3)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29053990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E24859
Product name: Protocatechuic acid ethyl ester
Purity: 97%
Packaging: 5g
Price: $43.8
Updated: 2024/03/01

TCI Chemical

Product number: D0571
Product name: Ethyl 3,4-Dihydroxybenzoate
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $26
Updated: 2024/03/01

TCI Chemical

Product number: D0571
Product name: Ethyl 3,4-Dihydroxybenzoate
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $64
Updated: 2024/03/01

Alfa Aesar

Product number: A11001
Product name: Ethyl 3,4-dihydroxybenzoate, 98%
Packaging: 10g
Price: $41.65
Updated: 2024/03/01

Alfa Aesar

Product number: A11001
Product name: Ethyl 3,4-dihydroxybenzoate, 98%
Packaging: 50g
Price: $165.65
Updated: 2024/03/01

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Ethyl 3,4-dihydroxybenzoate Chemical Properties,Usage,Production

Description

Ethyl 3,4-dihydroxybenzoate (EDHB) is an analogue of 2-oxoglutarate and thus a competitive inhibitor of prolyl hydroxylase domain enzymes (PHDs). It is known as protocatechuic acid and is present in plant foods such as olives, roselle, du-zhong, and white grape wine.This compound have antioxidant, cardioprotective, neuroprotective, antimicrobial, anti-inflammatory and myoprotective activity, as well as anti-ulcer activity[1].

Chemical Properties

pale yellow to beige crystalline powder

Uses

An antioxidant compound found in Sicilian virgin olive oils and red wines.

Uses

The compound is a prolyl 4-hydroxylase inhibitor and can be used to protect the myocardium.

Definition

ChEBI: An ethyl ester resulting from the formal condensation of the carboxy group of 3,4-dihydroxybenzoic acid with ethanol. It is the anti-oxidative component of peanut seed testa.

Biological Activity

Ethyl 3,4-dihydroxybenzoate (EDHB) contains reducible polyphenol hydroxyl groups and exhibits antioxidant activity. Recent studies have shown that EDHB acts as an analog of the substrate α-ketoglutarate and competes for prolyl-hydroxylase activity, thus acting as an inhibitor and effectively inhibiting collagen synthesis and breast cancer metastasis. In addition, in vitro and animal studies in a cerebral ischemic rat model have revealed that EDHB shows increased protective effects and improves rat behavior by inhibiting free radical damage[2].

References

[1] Charu Nimker. "Ethyl 3,4-dihydroxy benzoate, a unique preconditioning agent for alleviating hypoxia-mediated oxidative damage in L6 myoblasts cells." Journal of Physiological Sciences 65 1 (2015): 77–87.
[2] Bo Han. "A prolyl-hydroxylase inhibitor, ethyl-3,4-dihydroxybenzoate, induces cell autophagy and apoptosis in esophageal squamous cell carcinoma cells via up-regulation of BNIP3 and N-myc downstream-regulated gene-1." PLoS ONE (2014): e107204.

Ethyl 3,4-dihydroxybenzoate Preparation Products And Raw materials

Raw materials

Benzoic acid

Preparation Products

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Ethyl 3,4-dihydroxybenzoate Suppliers

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View Lastest Price from Ethyl 3,4-dihydroxybenzoate manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Ethyl 3,4-dihydroxybenzoate 3943-89-3
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-11-20

Hebei Weibang Biotechnology Co., Ltd

Product: Ethyl 3,4-dihydroxybenzoate 3943-89-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-18

Hebei Weibang Biotechnology Co., Ltd

Product: Ethyl 3,4-dihydroxybenzoate 3943-89-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-31

3943-89-3, Ethyl 3,4-dihydroxybenzoateRelated Search:

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3,4-DIHYDROXYBENZOIC ACID ETHYL ESTER

ETHYL 3,4-DIHYDROXYBENZOATE

ETHYL PROTOCATECHUATE

RARECHEM AL BI 0069

PROTOCATECHUIC ACID ETHYL ESTER

3,4-DIHYDROXYBENZOIC ACID ETHYL ESTER 97%

3,4-DIHYDROXYBENZOIC ACID ETHYL ESTER 98+%

ETHYL 3,4-DIHYDROXYBENZOATE (PROTOCATECHUIC ACID ETHYL ESTER)

3,4-dihydroxybenzate ethyl ester

Benzoic acid, 3,4-dihydroxy-, ethyl ester

EDHB

Ethyl 3,4-dihydroxybenzoate,97%

Ethyl 3,4-dihydroxyb

3,4-2-ethyl

3,4-Dichydroxybenzoic acid ethyl ester

Erlotinib interMidiate I

Ethyl 3,4-dihydroxybenzoate, 97% 25GR

NSC 619681

NSC 86130

3,4-Dihydroxybenzoic Acid Ethyl Ester Ethyl Protocatechuate Protocatechuic Acid Ethyl Ester

3,4-Dihydroxybenzoic acid ethy ester

4-(Ethoxycarbonyl)catechol, 4-(Ethoxycarbonyl)benzene-1,2-diol

Protocatechuic acid ethyl ester 97%

Ethyl 3,4-dihydroxybenzoat

Protocatechuic acid ethyl ester, >=99%

3,4-DIHYDROXYBENZOIC ACID E

ERLOTINIBINT-A

N,N-Diethylnicotinamide 3,4-DIHYDROXYBENZOIC ACID ETHYL ESTER

Ethyl 3,4-dihydroxybenzoate in stock Factory

Ethyl 3,4-dinhydroxybenzoate

Ethyl 3,4-Dihydroxybenzoate &gt

Ethyl 3,4-dihydroxybenzoate-98%

3943-89-3

HO2C6H3CO2C2H5

Esters

Organic Building Blocks

Building Blocks

C8 to C9

Carbonyl Compounds

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals

HIF Prolyl-Hydroxylase Inhibitors

Aerobic Glycolysis (the Warburg Effect)

Building Blocks

C8 to C9

Cancer Metabolism

Cancer Research

Carbonyl Compounds

Chemical Synthesis

Esters

Inhibitors of Aerobic Glycolysis (the Warburg Effect)

Organic Building Blocks

FINE Chemical & INTERMEDIATES

Aromatic Esters

Benzoic acid

Organic acids

API intermediates