ChemicalBook > CAS DataBase List > 4-(1H-1,2,4-Triazol-1-ylmethyl)aniline

4-(1H-1,2,4-Triazol-1-ylmethyl)aniline

Product Name
4-(1H-1,2,4-Triazol-1-ylmethyl)aniline
CAS No.
119192-10-8
Chemical Name
4-(1H-1,2,4-Triazol-1-ylmethyl)aniline
Synonyms
AIDS339154;AIDS-339154;ZERO/004632;BAS 10150896;ZINC00337935;AKOS B030090;AR-011/40584933;Rizatriptan Impurity 11;4-Triazol-1-ylmethyl)aniline;1-(4-AMINOBENZYL)-1,2,4-TRIAZOL
CBNumber
CB0176365
Molecular Formula
C9H10N4
Formula Weight
174.2
MOL File
119192-10-8.mol
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4-(1H-1,2,4-Triazol-1-ylmethyl)aniline Property

Melting point:
124 °C
Boiling point:
402.1±47.0 °C(Predicted)
Density 
1.26±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
4.42±0.10(Predicted)
form 
Powder
color 
White to pale yellow
InChI
InChI=1S/C9H10N4/c10-9-3-1-8(2-4-9)5-13-7-11-6-12-13/h1-4,6-7H,5,10H2
InChIKey
ZGLQVRIVLWGDNA-UHFFFAOYSA-N
SMILES
C1(N)=CC=C(CN2C=NC=N2)C=C1
CAS DataBase Reference
119192-10-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38-41-37/38
Safety Statements 
22-26-36/37/39
HazardClass 
6.1
HazardClass 
IRRITANT
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2148
Product name
4-(1,2,4-Triazol-1-ylmethyl)aniline
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$16
Updated
2025/07/31
TCI Chemical
Product number
A2148
Product name
4-(1,2,4-Triazol-1-ylmethyl)aniline
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$30
Updated
2025/07/31
TRC
Product number
T767530
Product name
4-(1H-1,2,4-Triazol-1-ylmethyl)benzenamine
Packaging
2g
Price
$195
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM1054194
Product name
[4-(1H-1,2,4-TRIAZOL-1-YLMETHYL)PHENYL]AMINE
Purity
95.00%
Packaging
1G
Price
$117.6
Updated
2021/12/16
Matrix Scientific
Product number
027381
Product name
4-(1H-1,2,4-Triazol-1-ylmethyl)aniline
Packaging
100g
Price
$120
Updated
2021/12/16
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4-(1H-1,2,4-Triazol-1-ylmethyl)aniline Chemical Properties,Usage,Production

Chemical Properties

Brown Solid

Uses

Rizatriptan intermediate

Uses

4-(1H-1,2,4-Triazol-1-ylmethyl)benzenamine is an intermediate useful in organic synthesis and other chemical processes.

Synthesis

119192-09-5

119192-10-8

General procedure for the synthesis of 4-[1H-1,2,4-triazol-1-ylmethyl]aniline from 1-(4-nitrophenyl)methyl-1,2,4-triazole: 1-(4-nitrophenyl)methyl-1,2,4-triazole (10.0 g, 49 mmol) was dissolved in a mixed solvent of ethanol (50 ml) and ethyl acetate (50 ml), 5N HCl (10 ml) and water (1 g). The hydrogenation reaction was carried out in a Parr hydrogenation unit at 40 psi hydrogen pressure using 10% Pd/C catalyst (1.0 g) until the hydrogen uptake reached 188 psi (about 10 min). Upon completion of the reaction, the catalyst was removed by Hyflo filtration and the solvent was removed by concentration under vacuum. The residue was azeotroped twice with ethanol to afford the target product 1-(4-aminophenyl)methyl-1,2,4-triazole hydrochloride (10.6 g, 100%). The product was confirmed by NMR hydrogen spectrum (360 MHz, D2O): δ 5.53 (2H, s, CH2), 7.37-7.48 (4H, m, Ar-H), 8.12 (1H, s, Ar-H), 8.66 (1H, s, Ar-H).

References

[1] Patent: US5567726, 1996, A
[2] Patent: US5298520, 1994, A
[3] Farmaco, 1989, vol. 44, # 9, p. 831 - 841
[4] European Journal of Medicinal Chemistry, 1989, vol. 24, # 5, p. 537 - 540
[5] Patent: US5567819, 1996, A

4-(1H-1,2,4-Triazol-1-ylmethyl)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(1H-1,2,4-Triazol-1-ylmethyl)aniline Suppliers

Americas 1 Belgium 2 Canada 2 China 155 Europe 2 Germany 4 India 38 Japan 1 Russia 1 South Korea 1 Switzerland 2 The Netherlands 1 Ukraine 2 United Kingdom 12 United States 39 Global 263
Unachem Trading Co., Ltd.
Tel
--
Fax
--
Email
unachem@ktnet.co.kr
Country
South Korea
ProdList
1181
Advantage
30
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View Lastest Price from 4-(1H-1,2,4-Triazol-1-ylmethyl)aniline manufacturers

Anhui Ruihan Technology Co., Ltd
Product
4-(1H-1,2,4-Triazol-1-ylmethyl)aniline 119192-10-8
Price
US $50.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000tons
Release date
2023-09-08
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-(1H-1,2,4-Triazol-1-ylmethyl)aniline 119192-10-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-(1,2,4-Triazol-1-ylmethyl)aniline 119192-10-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

119192-10-8, 4-(1H-1,2,4-Triazol-1-ylmethyl)anilineRelated Search:

N,N-Dimethylaniline ANILINE BLACK 3,3',5,5'-Tetramethylbenzidine dihydrochloride Tolyltriazole N,N-Dimethyl-1,4-phenylenediamine Aniline o-Toluidine N-Methylaniline 4-(1H-1,2,4-Triazol-1-ylmethyl)benzenamine hydrochloride 1-[(4-Hydrazinophenyl)methyl]-1H-1,2,4-triazole hydrochloride 1-(4-Nitrophenyl)methyl-1,2,4-triazole Rizatriptan 1,2,4-Triazole 1,2,3-1H-Triazole 1-(4-HYDRAZINOBENZYL)-1H-1,2,4-TRIAZOLE 2-(1H-1,2,4-TRIAZOL-1-YLMETHYL)ANILINE 3-(1H-1,2,4-TRIAZOL-1-YLMETHYL)ANILINE 4-(1H-1,2,4-Triazol-1-ylmethyl)aniline

  • 1-(4-Aminobenzyl)-1H-1,2,4-triazole
  • 4-(1H-1,2,4-Triazol-1-ylmethyl)aniline 97%
  • 4-(1H-1,2,4-triazol-1-ylmethyl)-benzenamine( For Rizatriptan )
  • 4-[1H-1,2,4-TRIAZOLE-1-YL METHYL]BENZENE AMINE (FOR RIZATRIPTAN)
  • 1-(4-Aminophenyl)methyl-1,2,4-Triazole see also 4-(1H-1,2,4-Triazol-1-yl-Methyl)Benzenamine
  • 1-(4-AMINOBENZYL)-1,2,4-TRIAZOL
  • Benzenamine, 4-(1H-1,2,4-triazol-1-ylmethyl)
  • AIDS339154
  • AIDS-339154
  • AR-011/40584933
  • BAS 10150896
  • ZERO/004632
  • ZINC00337935
  • 1-(4-AMINOPHENYL)METHYL-1,2,4-TRIAZOLE
  • 4-(1H-1,2,4-TRIAZOL-1-YLMETHYL)PHENYLAMINE
  • 4-(1H-1,2,4-TRIAZOL-1-YLMETHYL)ANILINE
  • 4-(1H-1,2,4-TRIAZOL-1-YL-METHYL)BENZENAMINE
  • 4-[1H-1,2,4-TRIAZOL-1-YL METHYL] BENZENEAMINE
  • 1-(4-Aminobenzyl)-1,2,4-triazole
  • 4-(1H-1,2,4-TRIZOL-YL-METHYL)-ANILINE
  • 4-(1 2 4-TRIAZOL-1-YLMETHYL)ANILINE
  • 4-(1H-1,2,4-TRIZOL-1-YL-METHYL)-BENZENAMINE
  • AKOS B030090
  • 4-[1,2,4]TRIAZOL-1-YLMETHYLPHENYLAMINE
  • 4-(1,2,4-Triazole-1-Yl)Methylphenylamine
  • 4-Triazol-1-ylmethyl)aniline
  • 4-(1,2,4-Triazol-1-ylmethyl)aniline &gt
  • 4-(1H-1,2,4-Triazol-1-ylmethyl)aniline ISO 9001：2015 REACH
  • Rizatriptan Impurity 11
  • -(1,2,4-TRIAZOL-1-YLMETHYL)ANILINE
  • 1-(4-Aminobenzyl)-1,2,4-triazole, >98%
  • 119192-10-8
  • C9H10N4
  • Intermediates of Rizatriptan
  • Amine
  • Aromatics
  • Heterocycles
  • Phenyls & Phenyl-Het
  • Chemical Amines
  • Amines
  • Anilines, Aromatic Amines and Nitro Compounds