ChemicalBook > CAS DataBase List > 4-AMINO-2,6-DIFLUOROPYRIDINE

4-AMINO-2,6-DIFLUOROPYRIDINE

Product Name
4-AMINO-2,6-DIFLUOROPYRIDINE
CAS No.
63489-58-7
Chemical Name
4-AMINO-2,6-DIFLUOROPYRIDINE
Synonyms
2,6-difluoropyridin-4-aMine;6-difluoropyridin-4-aMine;2,6-difluoro-4-PyridinaMine;4-AMINO-2,6-DIFLUOROPYRIDINE;2,,6-difluoro-4-aminopyridine;4-Pyridinamine, 2,6-difluoro-;2,6-Difluoro-pyridin-4-ylamine;4-Amino-2,6-difluoropyridine 97%;4-Pyridinamine,2,6-difluoro-(9CI);4-AMINO-2,6-DIFLUOROPYRIDINE ISO 9001：2015 REACH
CBNumber
CB0183286
Molecular Formula
C5H4F2N2
Formula Weight
130.1
MOL File
63489-58-7.mol
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4-AMINO-2,6-DIFLUOROPYRIDINE Property

Melting point:
124-125
Boiling point:
267.8±35.0 °C(Predicted)
Density 
1.393±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
solid
pka
-0.33±0.10(Predicted)
color 
Pale yellow
InChI
InChI=1S/C5H4F2N2/c6-4-1-3(8)2-5(7)9-4/h1-2H,(H2,8,9)
InChIKey
OWXBXLGJIFPPMS-UHFFFAOYSA-N
SMILES
C1(F)=NC(F)=CC(N)=C1
CAS DataBase Reference
63489-58-7
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Safety

Hazard Codes 
T
RIDADR 
2811
HazardClass 
6.1
PackingGroup 
Ⅲ
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
D456008
Product name
2,6-difluoropyridin-4-amine
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
D456008
Product name
2,6-difluoropyridin-4-amine
Packaging
500mg
Price
$130
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-3-W1
Product name
4-Amino-2,6-difluoropyridine
Packaging
1g
Price
$130
Updated
2021/12/16
AK Scientific
Product number
9692AB
Product name
2,6-Difluoropyridin-4-amine
Packaging
1g
Price
$131
Updated
2021/12/16
Apolloscientific
Product number
PC9706
Product name
4-Amino-2,6-difluoropyridine
Purity
97%
Packaging
250mg
Price
$50
Updated
2021/12/16
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4-AMINO-2,6-DIFLUOROPYRIDINE Chemical Properties,Usage,Production

Synthesis Reference(s)

Journal of Medicinal Chemistry, 30, p. 340, 1987 DOI: 10.1021/jm00385a016

Synthesis

2840-00-8

63489-58-7

In a 500 mL autoclave, 49.8 g (0.25 mol) of 2,6-difluoro-3,5-dichloro-4-aminopyridine, 200 mL of ethanol, 5.61 g (0.55 mol) of triethylamine, and 10.0 g of 10% palladium carbon catalyst were added. The reaction system was maintained at 25 °C and a hydrogen pressure of 0.46 MPa was applied and the reaction lasted for 24 hours. Upon completion of the reaction, the system was cooled and the hydrogen pressure was slowly released. The catalyst was removed by diafiltration followed by distillation under reduced pressure to remove the solvent. The crude product was purified by column chromatography using petroleum ether/ethyl acetate (3:1 v/v) as eluent. The final product was 20.6 g of 2,6-difluoro-4-aminopyridine as a white solid, which was determined to be 99.7% pure by liquid chromatographic normalization in 63.5% yield.

References

[1] Journal of Medicinal Chemistry, 1987, vol. 30, # 2, p. 340 - 347
[2] Patent: CN104610250, 2017, B. Location in patent: Paragraph 0076; 0077; 0079

4-AMINO-2,6-DIFLUOROPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-AMINO-2,6-DIFLUOROPYRIDINE Suppliers

Canada 1 China 91 Europe 1 Germany 1 India 2 United Kingdom 2 United States 7 Global 105
BEIJINGYIWANJINGRUI
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15866847540
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dengyt2000@163.com
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China
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PharmaBlock Sciences (Nanjing),Inc.
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025-86918202 4000255188
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86-025-86918232
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sales@pharmablock.com
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China
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Alfa Aesar
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400-6106006
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021-67582001/03/05
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saleschina@alfa-asia.com
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Nanjing Lynsci Chemical Co., Ltd
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0086-25-83208253
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Shanghai Raise Chemical Technology Co.,Ltd
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Synchem OHG
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Shanghai YuanYe Biotechnology Co., Ltd.
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QQ:3008007432
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3008007409@qq.com
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China
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ChengDu TongChuangYuan Pharmaceutical Co.Ltd
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028-83379370 13880556291
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028-87747383
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tcy@tcypharm.com
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China
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Shanghai SuperLan Chemcial Technique Centre
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0-2022843681 15618226720
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+86-21-51601218
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chaolaichem@foxmail.com
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China
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View Lastest Price from 4-AMINO-2,6-DIFLUOROPYRIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-AMINO-2,6-DIFLUOROPYRIDINE 63489-58-7
Price
US $1.00-4.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2025-09-05
Shaanxi Dideu Medichem Co. Ltd
Product
4-AMINO-2,6-DIFLUOROPYRIDINE 63489-58-7
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-11-24
Shaanxi Dideu New Materials Co. Ltd
Product
4-AMINO-2,6-DIFLUOROPYRIDINE 63489-58-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-03-19

63489-58-7, 4-AMINO-2,6-DIFLUOROPYRIDINERelated Search:

3,5-Dichloro-4-amino-2,6-difluoropyridine 4-(DIMETHYLAMINO)-2,3,5,6-TETRAFLUOROPYRIDINE 4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE 4-AMINO-3-CHLORO-2,5,6-TRIFLUOROPYRIDINE 2-AMINO-3,5-DIFLUOROPYRIDINE 2,6-Difluoropyridine 2,3,5,6-TETRAFLUORO-4-HYDRAZINOPYRIDINE 2,3,5,6-TETRAFLUORO-4-NITROPYRIDINE 4-AMINO-3,5-DIFLUOROPYRIDINE N-[(3,5-DICHLOROPHENYL)SULFONYL]-4-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)PIPERAZINE-1-CARBOXAMIDE 2-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)-N-[4-(TRIFLUOROMETHYL)PHENYL]HYDRAZINECARBOXAMIDE 4-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)-N-{[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}PIPERAZINE-1-CARBOXAMIDE 2-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)-N-[4-(TRIFLUOROMETHOXY)PHENYL]HYDRAZINECARBOTHIOAMIDE 3,5-DICHLORO-2,6-DIFLUORO-4-HYDRAZINOPYRIDINE 3,5-dichloro-2,6-difluoro-N-methyl-4-pyridinamine N-[(3,4-DICHLOROPHENYL)SULFONYL]-4-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)PIPERAZINE-1-CARBOXAMIDE N-{[2-CHLORO-5-(TRIFLUOROMETHYL)PHENYL]SULFONYL}-4-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)PIPERAZINE-1-CARBOXAMIDE N-[(4-FLUOROPHENYL)SULFONYL]-4-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)PIPERAZINE-1-CARBOXAMIDE

  • 4-AMINO-2,6-DIFLUOROPYRIDINE
  • 2,,6-difluoro-4-aminopyridine
  • 4-Pyridinamine,2,6-difluoro-(9CI)
  • 2,6-difluoropyridin-4-aMine
  • 2,6-difluoro-4-PyridinaMine
  • 6-difluoropyridin-4-aMine
  • 4-Amino-2,6-difluoropyridine 97%
  • 4-Pyridinamine, 2,6-difluoro-
  • 4-AMINO-2,6-DIFLUOROPYRIDINE ISO 9001：2015 REACH
  • 2,6-Difluoro-pyridin-4-ylamine
  • 63489-58-7
  • PYRIDINE