ChemicalBook > CAS DataBase List > 2',4',5'-TRIMETHOXYACETOPHENONE

2',4',5'-TRIMETHOXYACETOPHENONE

Product Name
2',4',5'-TRIMETHOXYACETOPHENONE
CAS No.
1818-28-6
Chemical Name
2',4',5'-TRIMETHOXYACETOPHENONE
Synonyms
2,4,5-TRIMETHOXYACETOPHENONE;trimethyl(1-pyrazolyl)silane;2',4',5'-Trimethoxyacetophenone;2',4',5'-TRIMETHOXYACETOPHENONE;Acetophenone, 2',4',5'-trimethoxy-;1-(2,4,5-Trimethoxyphenyl)ethanone;1-(2,4,5-trimethoxyphenyl)ethan-1-one;Ethanone, 1-(2,4,5-trimethoxyphenyl)-
CBNumber
CB0184667
Molecular Formula
C11H14O4
Formula Weight
210.23
MOL File
1818-28-6.mol
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2',4',5'-TRIMETHOXYACETOPHENONE Property

Melting point:
98-102°C
Boiling point:
285-290 °C(Press: 33 Torr)
Density 
1.089±0.06 g/cm3(Predicted)
EPA Substance Registry System
Ethanone, 1-(2,4,5-trimethoxyphenyl)- (1818-28-6)
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
711233
Product name
2′,4′,5′-Trimethoxyacetophenone
Purity
97%
Packaging
25g
Price
$40.4
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
CHM0129205
Product name
2',4',5'-TRIMETHOXYACETOPHENONE
Purity
97.00%
Packaging
25G
Price
$1178.79
Updated
2021/12/16
AHH
Product number
MT-31478
Product name
2,4,5-Trimethoxyacetophenone
Purity
98%
Packaging
10g
Price
$455
Updated
2021/12/16
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2',4',5'-TRIMETHOXYACETOPHENONE Chemical Properties,Usage,Production

Preparation

Preparation by reaction of acetyl chloride with hydroxyhydroquinone trimethyl ether in the presence of aluminium chloride.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 33, p. 1155, 1990 DOI: 10.1021/jm00166a012

Synthesis

2,4,5-Trimethoxy acetophenone is synthesised using 2-Hydroxy-4,5-dimethoxy acetophenone as raw material by chemical reaction. The specific synthesis steps are as follows:
2-Hydroxy-4,5-dimethoxyacetophenone(5 g,0.0255 mole) in dry acetone (100 ml)is refluxed for 30 hr under anhydrous conditions with dimethyl sulphate (2.8 ml,3.78 g,0.03 mole)and ignited potassium carbonate (20 g).The mixture is filtered and the inorganic residue washed with hot acetone (2 x 20 ml).The combined acetone solution is distilled and the oily residue macerated with crushed ice.The solid product is filtered,washed with water and dried.It is crystallised from benzene as colourless needles.Yield 4.5g (84.1%).M.p.97(lit.m.p.102).

2',4',5'-TRIMETHOXYACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2',4',5'-TRIMETHOXYACETOPHENONE Suppliers

Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
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Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19172
Advantage
64
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
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80
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
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58
Yantai ShengKailun Chemical Technology Co., Ltd.
Tel
13356901049
Fax
QQ:1025383091
Email
3119594100@qq.com
Country
China
ProdList
7958
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Shanghai QiQiao Biological Technology Co., Ltd.
Tel
021-37653318; 15221675714
Email
515366396@qq.com
Country
China
ProdList
2089
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58
Nanjing NingFan Pharm-Tech CO. LTD.
Tel
17368696818
Country
China
ProdList
1984
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Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
Tel
15229059051
Email
1027@dideu.com
Country
China
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Yantai Sheng Kai Lun Biological Products Co. , Ltd.
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3119594100
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mark@sklnchem.cn
Country
China
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Zhuhai Aobokai Biomedical Technology Co., Ltd.
Tel
400-0628126 15976997964;
Email
sales-team@aobchem.com.cn
Country
China
ProdList
50056
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1818-28-6, 2',4',5'-TRIMETHOXYACETOPHENONERelated Search:


  • 2',4',5'-TRIMETHOXYACETOPHENONE
  • 2,4,5-TRIMETHOXYACETOPHENONE
  • 1-(2,4,5-Trimethoxyphenyl)ethanone
  • Acetophenone, 2',4',5'-trimethoxy-
  • Ethanone, 1-(2,4,5-trimethoxyphenyl)-
  • 1-(2,4,5-trimethoxyphenyl)ethan-1-one
  • trimethyl(1-pyrazolyl)silane
  • 2',4',5'-Trimethoxyacetophenone
  • 1818-28-6
  • KETONE
  • Aromatic Acetophenones & Derivatives (substituted)