ChemicalBook > CAS DataBase List > 2',4',5'-TRIMETHOXYACETOPHENONE

2',4',5'-TRIMETHOXYACETOPHENONE

Product Name
2',4',5'-TRIMETHOXYACETOPHENONE
CAS No.
1818-28-6
Chemical Name
2',4',5'-TRIMETHOXYACETOPHENONE
Synonyms
2,4,5-TRIMETHOXYACETOPHENONE;trimethyl(1-pyrazolyl)silane;2',4',5'-Trimethoxyacetophenone;2',4',5'-TRIMETHOXYACETOPHENONE;Acetophenone, 2',4',5'-trimethoxy-;1-(2,4,5-Trimethoxyphenyl)ethanone;1-(2,4,5-trimethoxyphenyl)ethan-1-one;Ethanone, 1-(2,4,5-trimethoxyphenyl)-
CBNumber
CB0184667
Molecular Formula
C11H14O4
Formula Weight
210.23
MOL File
1818-28-6.mol
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2',4',5'-TRIMETHOXYACETOPHENONE Property

Melting point:
98-102°C
Boiling point:
285-290 °C(Press: 33 Torr)
Density 
1.089±0.06 g/cm3(Predicted)
EPA Substance Registry System
Ethanone, 1-(2,4,5-trimethoxyphenyl)- (1818-28-6)
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
711233
Product name
2′,4′,5′-Trimethoxyacetophenone
Purity
97%
Packaging
25g
Price
$40.4
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
CHM0129205
Product name
2',4',5'-TRIMETHOXYACETOPHENONE
Purity
97.00%
Packaging
25G
Price
$1178.79
Updated
2021/12/16
AHH
Product number
MT-31478
Product name
2,4,5-Trimethoxyacetophenone
Purity
98%
Packaging
10g
Price
$455
Updated
2021/12/16
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2',4',5'-TRIMETHOXYACETOPHENONE Chemical Properties,Usage,Production

Preparation

Preparation by reaction of acetyl chloride with hydroxyhydroquinone trimethyl ether in the presence of aluminium chloride.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 33, p. 1155, 1990 DOI: 10.1021/jm00166a012

Synthesis

2,4,5-Trimethoxy acetophenone is synthesised using 2-Hydroxy-4,5-dimethoxy acetophenone as raw material by chemical reaction. The specific synthesis steps are as follows:
2-Hydroxy-4,5-dimethoxyacetophenone(5 g,0.0255 mole) in dry acetone (100 ml)is refluxed for 30 hr under anhydrous conditions with dimethyl sulphate (2.8 ml,3.78 g,0.03 mole)and ignited potassium carbonate (20 g).The mixture is filtered and the inorganic residue washed with hot acetone (2 x 20 ml).The combined acetone solution is distilled and the oily residue macerated with crushed ice.The solid product is filtered,washed with water and dried.It is crystallised from benzene as colourless needles.Yield 4.5g (84.1%).M.p.97(lit.m.p.102).

2',4',5'-TRIMETHOXYACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2',4',5'-TRIMETHOXYACETOPHENONE Suppliers

Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71

1818-28-6, 2',4',5'-TRIMETHOXYACETOPHENONERelated Search:


  • 2',4',5'-TRIMETHOXYACETOPHENONE
  • 2,4,5-TRIMETHOXYACETOPHENONE
  • 1-(2,4,5-Trimethoxyphenyl)ethanone
  • Acetophenone, 2',4',5'-trimethoxy-
  • Ethanone, 1-(2,4,5-trimethoxyphenyl)-
  • 1-(2,4,5-trimethoxyphenyl)ethan-1-one
  • trimethyl(1-pyrazolyl)silane
  • 2',4',5'-Trimethoxyacetophenone
  • 1818-28-6
  • KETONE
  • Aromatic Acetophenones & Derivatives (substituted)