α-Naphthoflavone

Product Name: α-Naphthoflavone
CAS No.: 604-59-1
Chemical Name: α-Naphthoflavone
Synonyms: BENZOFLAVONE;benzo(h)flavone;-Naphthoflavone;α-naphtoflavone;7,8-BENZOFLAVONE;à-naphthoflavone;A-NAPHTHOFLAVONE;1-Naphthoflavone;α-Naphthoflavone;a-Naphthylflavone
CBNumber: CB0184955
Molecular Formula: C19H12O2
Formula Weight: 272.3
MOL File: 604-59-1.mol

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α-Naphthoflavone Property

Melting point:: 153-157 °C (lit.)
Boiling point:: 375.35°C (rough estimate)
Density: 1.1382 (rough estimate)
refractive index: 1.5510 (estimate)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Crystalline Powder or Crystals
color: yellow
BRN: 210862
Stability:: Stable. Incompatible with strong oxidizing agents.
LogP: 5.003 (est)
CAS DataBase Reference: 604-59-1(CAS DataBase Reference)
EPA Substance Registry System: 4H-Naphtho[1,2-b]pyran-4-one, 2-phenyl- (604-59-1)

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Safety

Hazard Codes: Xi,Xn,C,F
Risk Statements: 68-34-11
Safety Statements: 24/25-36/37-45-36/37/39-26-16
WGK Germany: 3
RTECS: QL6250000
F: 8
Hazard Note: Irritant
TSCA: Yes
HS Code: 29143990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N5757
Product name: α-Naphthoflavone
Purity: ≥98%
Packaging: 1g
Price: $48.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: N5757
Product name: α-Naphthoflavone
Purity: ≥98%
Packaging: 5g
Price: $51.66
Updated: 2024/03/01

TCI Chemical

Product number: B0056
Product name: alpha-Naphthoflavone
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $18
Updated: 2024/03/01

TCI Chemical

Product number: B0056
Product name: alpha-Naphthoflavone
Purity: >98.0%(HPLC)
Packaging: 5g
Price: $50
Updated: 2024/03/01

Alfa Aesar

Product number: A18542
Product name: alpha-Naphthoflavone, 97%
Packaging: 5g
Price: $51.65
Updated: 2024/03/01

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α-Naphthoflavone Chemical Properties,Usage,Production

Chemical Properties

yellow powder

Uses

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. α-Naphthoflavone is a flavone that modulates xenobiotic metabolism at several points. It antagonizes AhR, blocking the expression of phase I and II genes at nanomolar concentrations, although it can agonize AhR at higher concentrations (10 μM). α-Naphthoflavone inhibits CYP19 (aromatase), CYP1A1, CYP1A2, and CYP1B1 (IC50s = 500, 60, 6, and 5 nM, respectively), whereas it activates CYP3A4 (Kd = 7.4 μM). Dietary α-naphthoflavone can contribute to carcinogenesis in the presence of synthetic estrogens.[Cayman Chemical]

Uses

α-Naphthylflavone is a flavenoid compound that acts on μ-opioid receptors in the treatment of pain. Also acts as a non-steroidal aromatase inhibitor used in breast cancer therapy.

Definition

ChEBI: An extended flavonoid resulting from the formal fusion of a benzene ring with the h side of flavone. A synthetic compound, it is an inhibitor of aromatase (EC 1.14.14.14).

Purification Methods

Recrystallise the flavone from EtOH or aqueous EtOH. [IR: Cramer & Windel Chem Ber 89 354 1956, UV Pillon & Massicot Bull Soc Chim Fr 26 1954, Smith J Chem Soc 542

α-Naphthoflavone Preparation Products And Raw materials

Raw materials

FLAVANONE FLAVONE trans-Chalcone

Preparation Products

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α-Naphthoflavone Suppliers

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View Lastest Price from α-Naphthoflavone manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: α-Naphthoflavone 604-59-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98.0%
Supply Ability: 1kg/month
Release date: 2023-02-13

Hebei Yanxi Chemical Co., Ltd.

Product: α-Naphthoflavone 604-59-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-11-14

Hebei Weibang Biotechnology Co., Ltd

Product: α-Naphthoflavone 604-59-1
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

604-59-1, α-NaphthoflavoneRelated Search:

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Supply high quality Alpha-Naphthoflavone CAS 604-59-1 with fast delivery

α-Naphthylflavone

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Naphthol flavone impurity 1

Quinagolide Hydrochloride-d10

α-Naphthoflavone, ≥ 98.0%

604-59-1

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