2-HYDROXY-3-NITROACETOPHENONE

Product Name: 2-HYDROXY-3-NITROACETOPHENONE
CAS No.: 28177-69-7
Chemical Name: 2-HYDROXY-3-NITROACETOPHENONE
Synonyms: 2-HYDROXY-3-NITROACETOPHENONE;2’-hydroxy-3-nltroacetophenone;2’-Hydroxy-3’-nitroacetophenone;1-(2-HYDROXY-3-NITRO-PHENYL)-ETHANONE;Ethanone, 1-(2-hydroxy-3-nitrophenyl)-;1-(2-hydroxy-3-nitrophenyl)ethan-1-one;2-hydroxy-1-(3-nitrophenyl)ethan-1-one
CBNumber: CB0186207
Molecular Formula: C8H7NO4
Formula Weight: 181.15
MOL File: 28177-69-7.mol

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2-HYDROXY-3-NITROACETOPHENONE Property

Melting point:: 98.5-99.5 °C
Boiling point:: 223.5±20.0 °C(Predicted)
Density: 1.380±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 7.31±0.24(Predicted)
Appearance: Yellow to brown Solid
InChI: InChI=1S/C8H7NO4/c1-5(10)6-3-2-4-7(8(6)11)9(12)13/h2-4,11H,1H3
InChIKey: XQZGSPSZLMKODN-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC=CC([N+]([O-])=O)=C1O)C
CAS DataBase Reference: 28177-69-7(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: H950973
Product name: 2-Hydroxy-3-nitroacetophenone
Packaging: 500mg
Price: $110
Updated: 2021/12/16

AK Scientific

Product number: W5104
Product name: 1-(2-Hydroxy-3-nitrophenyl)ethanone
Packaging: 5g
Price: $162
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0016604
Product name: 1-(2-HYDROXY-3-NITRO-PHENYL)-ETHANONE
Purity: 95.00%
Packaging: 5G
Price: $921.69
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0016604
Product name: 1-(2-HYDROXY-3-NITRO-PHENYL)-ETHANONE
Purity: 95.00%
Packaging: 25G
Price: $1552.32
Updated: 2021/12/16

AK Scientific

Product number: W5104
Product name: 1-(2-Hydroxy-3-nitrophenyl)ethanone
Packaging: 10g
Price: $235
Updated: 2021/12/16

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2-HYDROXY-3-NITROACETOPHENONE Chemical Properties,Usage,Production

Preparation

Preparation by reaction of boiling 5% aqueous potassium hydroxide on 8-nitrochromone (78%).

Synthesis

118-93-4

1450-76-6

28177-69-7

General procedure for the synthesis of 2-hydroxy-5-nitroacetophenone and 2-hydroxy-3-nitroacetophenone from 2'-hydroxyacetophenone: In a four-necked flask, 2'-hydroxyacetophenone (175 g), acetic acid (183 g), and dichloromethane (800 mL) were added sequentially, and the mixture was heated to 40 °C. Subsequently, 63% concentrated nitric acid (165 g) was slowly added dropwise, and the reaction temperature was controlled to be maintained at 40 °C for 4-6 hours. After completion of the dropwise addition, the reaction was continued at 40 °C for 4-6 hours. At the end of the reaction, water (500 g) was added and stirred for 30 minutes for extraction and layering. The organic layer was concentrated to about 200 g of crude product. The above crude product (200 g) was added to a four-necked flask with toluene (900 g), heated to 60-70 °C and reacted at 70-80 °C for 2-4 hours. The reaction mixture was cooled to 30-50 °C and filtered and the filter cake was dried. The dried filter cake was transferred to a four-necked flask, methanol (100 g) and water (800 g) were added and heated to 50-60°C. The reaction mixture was cooled to 30-50°C and filtered. Acetic acid (150 g) was added slowly dropwise and controlled to be added dropwise within 2 hours at 60-70 °C. The reaction mixture was cooled to room temperature and filtered, and the filter cake was dried to give the product A-2 (80 g).

References

[1] Journal of Medicinal Chemistry, 1994, vol. 37, # 20, p. 3353 - 3362
[2] Journal of Medicinal Chemistry, 1994, vol. 37, # 20, p. 3353 - 3362
[3] Asian Journal of Chemistry, 2015, vol. 27, # 6, p. 2117 - 2124
[4] Patent: WO2009/85256, 2009, A1. Location in patent: Page/Page column 55
[5] Patent: CN103980257, 2016, B. Location in patent: Paragraph 0033; 0034; 0035

2-HYDROXY-3-NITROACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-HYDROXY-3-NITROACETOPHENONE Suppliers

China 97 Europe 1 France 1 India 3 Ukraine 1 United Kingdom 4 United States 11 Global 118

Aladdin Scientific

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View Lastest Price from 2-HYDROXY-3-NITROACETOPHENONE manufacturers

RongNa Biotechnology Co.,Ltd

Product: 2-HYDROXY-3-NITROACETOPHENONE 28177-69-7
Price: US $10.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 1 ton
Release date: 2025-08-28

Shaanxi Dideu New Materials Co. Ltd

Product: 2-HYDROXY-3-NITROACETOPHENONE 28177-69-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-07

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-HYDROXY-3-NITROACETOPHENONE 28177-69-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

28177-69-7, 2-HYDROXY-3-NITROACETOPHENONERelated Search:

Benzoic acid,5-chloro-2-hydroxy-3-nitro- 2'-HYDROXY-5'-METHYL-3'-NITROACETOPHENONE 5'-BROMO-2'-HYDROXY-3'-NITROACETOPHENONE,5-BROMO-2-HYDROXY-3-NITROACETOPHENONE 4'-HYDROXY-3'-NITROACETOPHENONE,4-HYDROXY-3-NITROACETOPHENONE 2'-HYDROXY-5'-NITROACETOPHENONE,2-HYDROXY-5-NITROACETOPHENONE 2-BROMO-4'-HYDROXY-3'-NITROACETOPHENONE 1-(2-HYDROXY-5-METHYL-3-NITROPHENYL)PROPAN-1-ONE 5'-FLUORO-2'-HYDROXY-3'-NITRO- 5'-CHLORO-2'-HYDROXY-4'-METHYL-3'-NITROACETOPHENONE 6-FLUORO-8-NITROCHROMONE-3-CARBOXALDEHY& 2-HYDROXY-3-NITROACETOPHENONE 1,8-dihydroxy-2,4,5,7-tetranitroanthraquinone 2-BROMO-1-(5-ETHYL-2-METHOXY-3-NITROPHENYL)ETHANONE 2-BROMO-1-(5-CHLORO-2-METHOXY-4-METHYL-3-NITRO-PHENYL)ETHANONE 5'-CHLORO-2'-HYDROXY-3'-NITROPROPIOPHENONE 5'-ETHYL-2'-HYDROXY-3'-NITROACETOPHENONE 5'-BROMO-2'-HYDROXY-3'-NITROPROPIOPHENONE 4'-HYDROXY-2'-NITROACETOPHENONE

1-(2-HYDROXY-3-NITRO-PHENYL)-ETHANONE

2-HYDROXY-3-NITROACETOPHENONE

2’-hydroxy-3-nltroacetophenone

2-hydroxy-1-(3-nitrophenyl)ethan-1-one

1-(2-hydroxy-3-nitrophenyl)ethan-1-one

Ethanone, 1-(2-hydroxy-3-nitrophenyl)-

2’-Hydroxy-3’-nitroacetophenone

28177-69-7

28177-59-7

Aromatic Acetophenones & Derivatives (substituted)