ChemicalBook > CAS DataBase List > Methyl 3-amino-4-methylthiophene-2-carboxylate

Methyl 3-amino-4-methylthiophene-2-carboxylate

Product Name
Methyl 3-amino-4-methylthiophene-2-carboxylate
CAS No.
85006-31-1
Chemical Name
Methyl 3-amino-4-methylthiophene-2-carboxylate
Synonyms
3-AMINO-4-METHYL-2-THIOPHENECARBOXYLIC ACID METHYL ESTER;3-Amino Articaine;3-AMINO-4-METHYLTHIOPHENECARBOXYLIC ACID METHYL ESTER;M3A4MT2C;Articaine-002;Articaine Impurity I;Articaine Impurity 9;LABOTEST-BB LT00453517;Articaine EP Impurity I;Articaine intermediate E
CBNumber
CB0189112
Molecular Formula
C7H9NO2S
Formula Weight
171.22
MOL File
85006-31-1.mol
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Methyl 3-amino-4-methylthiophene-2-carboxylate Property

Melting point:
85-88 °C (lit.)
Boiling point:
318.6±37.0 °C(Predicted)
Density 
1.264±0.06 g/cm3(Predicted)
Flash point:
>100°C
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
1.71±0.10(Predicted)
form 
Solid
color 
Pale Yellow
Water Solubility 
1g/L at 35℃
BRN 
973196
InChIKey
YICRPERKKBDRSP-UHFFFAOYSA-N
LogP
1.28
CAS DataBase Reference
85006-31-1(CAS DataBase Reference)
NIST Chemistry Reference
Methyl 3-amino-4-methylthiophene-2-carboxylate(85006-31-1)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25-22
WGK Germany 
2
Hazard Note 
Irritant
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
546658
Product name
Methyl 3-amino-4-methylthiophene-2-carboxylate
Purity
97%
Packaging
5g
Price
$33.2
Updated
2024/03/01
Sigma-Aldrich
Product number
546658
Product name
Methyl 3-amino-4-methylthiophene-2-carboxylate
Purity
97%
Packaging
25g
Price
$127
Updated
2024/03/01
TCI Chemical
Product number
M1772
Product name
Methyl 3-Amino-4-methylthiophene-2-carboxylate
Purity
>98.0%(GC)
Packaging
5g
Price
$29
Updated
2024/03/01
TCI Chemical
Product number
M1772
Product name
Methyl 3-Amino-4-methylthiophene-2-carboxylate
Purity
>98.0%(GC)
Packaging
25g
Price
$101
Updated
2024/03/01
Alfa Aesar
Product number
A10115
Product name
Methyl 3-amino-4-methylthiophene-2-carboxylate, 98%
Packaging
5g
Price
$59.2
Updated
2021/12/16
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Methyl 3-amino-4-methylthiophene-2-carboxylate Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

Methyl 3-Amino-4-methylthiophene-2-carboxylate is a versatile reactant used in various syntheses. It is used in the preparation of (oxalylamino)benzoic acids and (carboxyheteroarylamino)oxalic acids as selective and orally bioavailable nonpeptide inhibitors of protein-tyrosine phosphatase 1B.

Application

methyl 3-amino-4-methylthiophene-2-carboxylate is the starting material used in the synthesis of the local anesthetic articaine.
7-Methylthieno[3,2-d]pyrimidin-4(3H)-one was prepared using methyl 3-amino-4-methylthiophene-2-carboxylate.
The reaction of 4-bromotoluene (0.171 g, 1 mmol), methyl 3-amino-4-methylthiophene-2-carboxylate(0.342 g, 2 mmol) and KOAc (0.196 g, 2 mmol) in the presence of PdCl(C3H5)(dppb) (12.2 mg, 0.02mmol) in DMAc at 120 °C affords the corresponding Methyl 3-amino-4-methyl-5-p-tolylthiophene-2-carboxylate in 81% (0.212 g) isolated yield.

Definition

ChEBI: Methyl 3-amino-4-methylthiophene-2-carboxylate is a thiophenecarboxylic acid.

Methyl 3-amino-4-methylthiophene-2-carboxylate Preparation Products And Raw materials

Raw materials

Methyl thioglycolate Sodium hydride Ethanol Hydroxylamine hydrochloride Methyl methacrylate

Preparation Products

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Methyl 3-amino-4-methylthiophene-2-carboxylate Suppliers

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View Lastest Price from Methyl 3-amino-4-methylthiophene-2-carboxylate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Methyl 3-amino-4-methylthiophene-2-carboxylate 85006-31-1
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%min HPLC
Supply Ability
1000kgs
Release date
2021-07-16
Hebei Weibang Biotechnology Co., Ltd
Product
Methyl 3-amino-4-methylthiophene-2-carboxylate 85006-31-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-20
Shaanxi Dideu Medichem Co. Ltd
Product
Methyl 3-amino-4-methylthiophene-2-carboxylate 85006-31-1
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-04-22

85006-31-1, Methyl 3-amino-4-methylthiophene-2-carboxylateRelated Search:

Methyl 4-(bromomethyl)benzoate Methyl anthranilate METSULFURON METHYL Basic Violet 1 Methyl salicylate Methanol Kresoxim-methyl Glycine Methylparaben Methyl 4-methylbenzoate 3-AMINOTHIOPHENE 2-Methylthiophene Methyl acrylate RESMETHRIN Tribenuron methyl Methyl carbamate Methyl METHYL 3-AMINO-4-CYANOTHIOPHENE-2-CARBOXYLATE

  • M3A4MT2C
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  • Methyl 3-amino-4-methyl-2-thenoate
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  • 2-Thiophenecarboxylic acid, 3-amino-4-methyl-, methyl ester
  • 4-Methyl-3-aminothiophene-2-carboxylic acid methyl ester
  • Methyl 3-amino-4-methylthiophene-2-carboxylate ,99%
  • 3-AMino-4-Methyl-2-thiophene carboxylic acid ester
  • 3-Amino-2-(methoxycarbonyl)-4-methylthiophene, Methyl 3-amino-4-methyl-2-thenoate
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  • 3-AMINO 4-METHYL-2-THIOPHENE CARBOXYLICACID METHYL ESTER IMPORTED VIDE B/E 3189721/ 06.11.2015][CLEAR AGAINST ADVANCE L
  • Articaine Impurity 9(Articaine EP Impurity I）
  • Articaine EP Impurity I
  • Methyl3-Amino-4-methylthiophene-2-carboxylate&gt
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  • Articaine-002
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  • 3- amino-4-methyl thiophene - 2-carboxylate, methyl ester
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  • Articaine Impurities1819
  • Articaine Impurity 9
  • Articaine Hydrochloride Impurity I
  • Articaine Hydrochloride EP Impurity I
  • 85006-31-1
  • C7H9SNO2
  • Heterocyclic Building Blocks
  • Thiophenes
  • Building Blocks
  • Thiophenes & Benzothiophenes
  • Building Blocks
  • C7 to C9
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • Thiophenes
  • Thiophen
  • Esters
  • Thiophenes & Benzothiophenes
  • Thiophene&Benzothiophene
  • Organic acids
  • API intermediates
  • 1
  • ADVANCED INT.