2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one

ChemicalBook > CAS DataBase List > 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one

2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one

Product Name: 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one
CAS No.: 27277-00-5
Chemical Name: 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one
Synonyms: ICI 63197;PP-796 emetic;Triazolopyrimidinones;ICI 63,197 >=98% (HPLC);AMINOPROPYLTRIAZOLOPYRIMIDONE;2-AMINO-6-METHYL-4-PROPYL-4H-[1,2,4]TRIAZOLO-[1,5-;2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one;2-Amio-6-methyl-4-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-...;2-azanyl-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one;2-AMINO-6-METHYL-4-PROPYL-[1,2,4]TRIAZOLO[1,5- AJPYRIMIDIN-5-ONE
CBNumber: CB0191331
Molecular Formula: C9H13N5O
Formula Weight: 207.23
MOL File: 27277-00-5.mol

Less

2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one Property

Melting point:: 161.8-163 °C
Boiling point:: 459.9±28.0 °C(Predicted)
Density: 1.44±0.1 g/cm3(Predicted)
vapor pressure: 0.004Pa at 25℃
storage temp.: 2-8°C
solubility: DMSO: 13 mg/mL
form: solid
pka: 2.96±0.40(Predicted)
color: white
Water Solubility: 5.7g/L at 20℃
InChIKey: UQDVRVNMIJAGRK-UHFFFAOYSA-N
LogP: 0.49 at 20℃
CAS DataBase Reference: 27277-00-5(CAS DataBase Reference)
EPA Substance Registry System: 2-Amino-4,5-dihydro-6-methyl-4-propyl-s-triazolo-(1,5-a)-pyrimidin-5-one (27277-00-5)

Less

Safety

RIDADR: 2811
WGK Germany: 1
HazardClass: 6.1(b)
PackingGroup: III

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I8283
Product name: ICI 63,197
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $207
Updated: 2024/03/01

Sigma-Aldrich

Product number: I8283
Product name: ICI 63,197
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $814
Updated: 2024/03/01

Usbiological

Product number: 255484
Product name: ICI 63197
Packaging: 10mg
Price: $403
Updated: 2021/12/16

TRC

Product number: I163888
Product name: ICI 63,197
Packaging: 250mg
Price: $305
Updated: 2021/12/16

TRC

Product number: I163888
Product name: ICI 63,197
Packaging: 25mg
Price: $185
Updated: 2021/12/16

Less

2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one Chemical Properties,Usage,Production

Uses

ICI 63197 is a specific cAMP phosphodiesterase (PDE) inhibitor. It is potent in anatagonizing reserpine-induced hypothermia. potent PDE4 inhibitor.

Definition

ChEBI: 2-amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one is a member of triazolopyrimidines.

Flammability and Explosibility

Not classified

Biological Activity

Potent phosphodiesterase (PDE) 4 inhibitor (IC 50 = 35 nM for inhibition of [ 3 H]-rolipram binding to rat brain). Antidepressant following systemic administration in vivo .

Biochem/physiol Actions

Phosphodiesterase IV (PDE 4) inhibitor

storage

+4°C

2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one Preparation Products And Raw materials

Raw materials

Preparation Products

Less

2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one Suppliers

China 123 Germany 3 India 1 Switzerland 1 United Kingdom 1 United States 20 USA 1 Global 150

UHN Shanghai Research & Development Co., Ltd.

Tel: 021-58958002 18930822973
Fax: 021-58958618
Email: xiaoyangw@gmail.com
Country: China
ProdList: 2129
Advantage: 58

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 18089
Advantage: 64

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3750
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7854
Advantage: 58

Shanghai Meishui Chemical Technology Co., Ltd

Tel: 021-60549325 18616193163
Fax: 021-33250306
Country: China
ProdList: 4528
Advantage: 56

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9636
Advantage: 58

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9911
Advantage: 50

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9798
Advantage: 50

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 18112977050
Email: cb6@aikonchem.com
Country: China
ProdList: 16687
Advantage: 50

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9972
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Hubei Chuangliankangcheng Pharmaceutical Co., Ltd.

Tel: 027-65388397 18164111589
Fax: 027-65388397
Email: 3321478047@qq.com
Country: China
ProdList: 1969
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27322
Advantage: 60

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9604
Advantage: 55

Shandong Xiya Chemical Co., Ltd.

Tel: 4009903999 13395398332
Fax: 0539-6365991
Email: sales@xiyashiji.com
Country: China
ProdList: 20810
Advantage: 60

Raw material medicin reagent co.,Ltd

Tel: 025-57798860
Email: sales@njromanme.com
Country: China
ProdList: 4534
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai SuperLan Chemcial Technique Centre

Tel: 021-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 9038
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Taian Jiaye Biotechnology Co.Ltd

Tel: 13127280945
Email: 285424065@qq.com
Country: China
ProdList: 9980
Advantage: 55

Shandong Ono Chemical Co., Ltd.

Tel: 0539-6362799 20）
Fax: 0539-6362799（To 20）
Country: China
ProdList: 10007
Advantage: 58

Wuhan Netcom Electronic Commerce Limited

Tel: 18064670521
Fax: 0757-88210752
Email: 2355935187@ycphar.com
Country: China
ProdList: 4887
Advantage: 58

Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Country: China
ProdList: 1988
Advantage: 58

Henan Alfachem Co.,Ltd.

Tel: 0371-0371-55051623 18137891487
Fax: QQ：2853979817
Email: 2853979817@qq.com
Country: China
ProdList: 9960
Advantage: 58

Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.

Tel: 027-51831887 15337167856
Fax: 027-51837635 QQ1165326703
Email: hubeixinyuanshun@163.com
Country: China
ProdList: 10305
Advantage: 58

Beijing altar ink quality inspection technology co., LTD

Tel: 010-52889049
Email: 2250970673@qq.com
Country: CHINA
ProdList: 1133
Advantage: 58

Aishilun biotechnology (Shanghai) co., LTD

Tel: 021-50676523 18019098996
Email: info@acelybio.com
Country: China
ProdList: 3967
Advantage: 58

TOSUN PHARM

Tel: 020-61855200 13326451905
Email: 2881290884@qq.com
Country: China
ProdList: 7497
Advantage: 58

Zhengzhou Alfa Chemical Co.,Ltd

Tel: +8618530059196
Email: sale04@alfachem.cn
Country: China
ProdList: 12733
Advantage: 58

Finetech Industry Limited

Tel: +86-27-87465837 +8618971612321
Fax: 86 27 87772287
Email: info@finetechnology-ind.com
Country: China
ProdList: 9635
Advantage: 58

ANHUI WITOP BIOTECH CO., LTD

Tel: +8615255079626
Email: eric@witopchemical.com
Country: China
ProdList: 23556
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: 0551-65418671
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34572
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 28506
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: 571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: CHINA
ProdList: 52867
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: 0571-85134551 18958018566;
Fax: 008657185134895
Email: info@afinechem.com
Country: China
ProdList: 15377
Advantage: 58

SIMAGCHEM CORP

Tel: +86-13806087780
Email: sale@simagchem.com
Country: China
ProdList: 17367
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28180
Advantage: 58

Guangdong Wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886766 13927870850
Fax: 0751-2886756
Email: 3001267247@qq.com
Country: China
ProdList: 10000
Advantage: 58

Wuhan xinyangruihe Chemical Technology Co., Ltd.

Tel: 027-83855313 15307155313
Fax: QQ：2274366233
Email: 2274366233@qq.com
Country: China
ProdList: 5661
Advantage: 58

Shanghai ningyuan trading co., ltd

Tel: 021-54415088 13003227123
Fax: 021-54415287
Email: 815219501@qq.com
Country: China
ProdList: 83
Advantage: 58

Nanjing Bermuda Biotechnology Co., Ltd.

Tel: 027-1734052141618086404407 17340521416
Fax: 17340521416
Email: 1757224788@qq.com
Country: China
ProdList: 2010
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49391
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 15093356674;
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29826
Advantage: 58

Wuhan lanabai Pharmaceutical Chemical Co., Ltd

Tel: 15307151931
Fax: QQ-2355680
Email: 2355680@qq.com
Country: China
ProdList: 8224
Advantage: 58

Beijing Aomi Jiade Pharmaceutical Technology Co., Ltd

Tel: 13522808617
Email: omiget@qq.com
Country: China
ProdList: 9213
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 4008210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 55023
Advantage: 58

Shanghai Zhongjun Chemical Co., Ltd.

Tel: 15618409868
Email: 2799011605@qq.com
Country: China
ProdList: 157
Advantage: 58

Shanghai Sig Biotechnology Co., LTD

Tel: 021-57810052 18930344717
Fax: 021-57810052
Email: 2089316240@qq.com
Country: China
ProdList: 9396
Advantage: 58

Jiaxing Hengrui Biotechnology Co. LTD

Tel: 0573-82672231 13757365595
Fax: QQ：715584339
Email: regen_chemical1@163.com
Country: China
ProdList: 3861
Advantage: 58

Less

View Lastest Price from 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one manufacturers

Dideu Industries Group Limited

Product: 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one 27277-00-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-17

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one 27277-00-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one 27277-00-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-23

27277-00-5, 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-oneRelated Search:

Kresoxim-methyl Tris(hydroxymethyl)aminomethane Cyclopropyl methyl ketone Sulfamerazine Propyl gallate N,N-Dimethyl-1,4-phenylenediamine 3-Methyl-2-butanone Pirimiphos-methyl Methylparaben Methanol Acetonitrile Paraquat dichloride Methyl acrylate Propyl butyrate Basic Violet 1 Methyl 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one

2-AMINO-6-METHYL-4-PROPYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-5(4H)-ONE

2-AMINO-6-METHYL-4-PROPYL-4H-[1,2,4] TRIAZOLE-[1,5-A] PYRIMIDINE-5-ONE

2-AMINO-6-METHYL-4-PROPYL-4H-[1,2,4]TRIAZOLO-[1,5-A]PYRIMIDIN-5-ONE

2-AMINO-6-METHYL-5-OXO-4-N-PROPYL-4,5-DIHYDRO-S-TRIAZOLE[1,5-A]PYRIMIDINE

ICI 63197

2,4]triazolo[1,5-a]pyrimidin-5(4h)-one,2-amino-6-methyl-4-propyl-[

2-Amio-6-methyl-4-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-5-one

2-AMINO-6-METHYL-5-OXO-4-N-PROPYL-4,5-DIHYDRO-S-TRIAZOLE[1,5-α]PYRIMIDIN

AMINOPROPYLTRIAZOLOPYRIMIDONE

2-AMINO-6-METHYL-4-PROPYL-4H-[1,2,4] TRIAZOLE-[1,5-A] PYRIMIDONE-5-ONE

PP796,2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one

1,2,4Triazolo1,5-apyrimidin-5(4H)-one, 2-amino-6-methyl-4-propyl-

2-AMINO-6-METHYL-5-OXO-4-N-PROPYL-4,5-DIHYDRO-S-TRIAZOLE[1,5- A ] PYRIMIDIN

2-AMINO-6-METHYL-4-PROPYL-4H-[1,2,4]TRIAZOLE-[1,5-ALPHA]PYRIMIDONE-5-ONE

2-AMINO-4,5-DIHYDRO-6-METHYL-4-PROPYL-S-TRIAZOLO(1,5-ALPHA)PYRIMIDIN-5-ONE

2-Amino-6-methyl-4-propyl-1,2,4-triazolo[1,5-a]pyrimidin-5(4H)-on

2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one

2-AMINO-6-METHYL-5-OXO-4-N-PROPYL-4,5-DIHYDRO-S-TRIAZOLE[1,5-ALPHA]PYRIMIDIN

PP-796 emetic

2-Amino-6-methyl-4-propyl-4,5-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-5-one

2-azanyl-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one

ICI 63,197,2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one

2-aMino-6-Methyl-4-propyl-4H,5H-[1,2,4]triazolo[1,5-a]pyriMidin-5-one

2-Amino-4,5-dihydro-6-methyl-4-propyl-s-triazolo-(1,5-A)-pyrimidin-5-one Caswell No. 033E

2-Amino-6-methyl-4-propyl-1,2,4-triazolo(1,5-a)pyrimidin-5(4H)-one 2-Amino-6-methyl-5-oxo-4n-propyl-4,5-dihydro-s-triazolo(1,5-a)pyrimidine 2-Amino-4,5-dihydro-6-methyl-4-propyl-5-triazolo-(1,5-c)-pyramidin-5-one 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one

ICI 63,197 >=98% (HPLC)

2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one USP/EP/BP

2-AMINO-6-METHYL-4-PROPYL-4H-[1,2,4]TRIAZOLO-[1,5-

2-Amio-6-methyl-4-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-...

Triazolopyrimidinones

2-AMINO-6-METHYL-4-PROPYL-[1,2,4]TRIAZOLO[1,5- AJPYRIMIDIN-5-ONE

27277-00-5

C3H13F5O

C9H13N5O

Biochemicals and Reagents

BioChemical

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors by Enzyme

Enzyme Inhibitors

Phosphodiesterase IV

P to Q

Cyclic Nucleotide related