ChemicalBook > CAS DataBase List > 7-Chloro-4-quinolinamine

7-Chloro-4-quinolinamine

Product Name
7-Chloro-4-quinolinamine
CAS No.
1198-40-9
Chemical Name
7-Chloro-4-quinolinamine
Synonyms
BUTTPARK 22\09-04;7-chloro-4-quinolinamine;7-chloro-4-aminoquinoline;4-AMINO-7-CHLOROQUINOLINE;4-QuinolinaMine,7-chloro-;(7-chloro-4-quinolyl)amine;7-CHLORO-QUINOLIN-4-YLAMINE;Hydroxychloroquine Impurity 34;4-amino-7-chloroQUINOLINE:7-chloro-4-quinolinamine
CBNumber
CB0199827
Molecular Formula
C9H7ClN2
Formula Weight
178.62
MOL File
1198-40-9.mol
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7-Chloro-4-quinolinamine Property

Melting point:
150-152.5 °C
Boiling point:
366.8±27.0 °C(Predicted)
Density 
1.363±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
solid
pka
7.49±0.50(Predicted)
color 
Off-white
CAS DataBase Reference
1198-40-9(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
25-36
Safety Statements 
26-45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
BBO000159
Product name
4-Amino-7-chloroquinoline
Purity
Aldrich
Packaging
1g
Price
$320
Updated
2024/03/01
TRC
Product number
C422285
Product name
7-Chloroquinolin-4-amine
Packaging
1g
Price
$415
Updated
2021/12/16
TRC
Product number
C422285
Product name
7-Chloroquinolin-4-amine
Packaging
250mg
Price
$165
Updated
2021/12/16
Apolloscientific
Product number
OR307952
Product name
4-Amino-7-chloroquinoline
Packaging
1g
Price
$185
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-5-3A
Product name
4-Amino-7-chloroquinoline
Purity
95%
Packaging
1g
Price
$220
Updated
2021/12/16
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7-Chloro-4-quinolinamine Chemical Properties,Usage,Production

Uses

7-Chloroquinolin-4-amine is an aminoquinoline that complexes ferriprotoporphyrin IX (Fe(III)PPIX) and inhibits its conversion to β-hematin (hemozoin).

Definition

ChEBI: 4-Amino-7-chloroquinoline is an aminoquinoline.

Synthesis Reference(s)

Journal of the American Chemical Society, 69, p. 704, 1947 DOI: 10.1021/ja01195a501

Synthesis

4-amino-7-chloroquinoline is obtained byreacting 7-chloro-4-hydrazinoquinoline ,sodium borohydride with nickel (II) chloride hexahydrate in methanol.To a suspension of 7-chloro-4-hydrazinoquinoline (1.67 g, 8.6 mmol) and nickel (II) chloride hexahydrate (2.00 g, 8.6 mmol) in methanol (33 ml), sodium borohydride (0.98 g, 25.8 mmol) was added cautiously while stirring the reaction mixture vigorously at room temperature and left to react overnight. The reaction mixture was filtered through celite pad. Water was used to dilute the filtrate layer and then washed with ethyl acetate. The organic layer was dried with magnesium sulphate and concentrated in vacuo to give the title compound as a yellow powder (1.09 g, 72%): mp: 143 – 147 ℃ (Lit.: 147 – 148 ℃) ;
vmax/cm-1 3337 s (N-H), 1642 m (C=N), 1609 m and 1575 m (C=N); δH (300 MHz; DMSO-d6) 8.28 (1H, d, J 5.3, C(2)H), 8.19 (1H, d, J 9.1, C(5)H), 7.76 (1H, d, J 1.6, C(8)H), 7.39 (1H, dd, J 9.1, 1.6, C(6)H), 7.03 (2H, s, NH2), 6.57 (1H, d, J 5.3, C(3)H); δC (75 MHz; DMSO-d6) 152.0 (Ar-C), 151.1 (C(2)H), 148.9 (Ar-C), 133.7 (Ar-C), 126.8 (C(8)H), 124.8 (C(5)H), 123.9 (C(6)H), 117.0 (Ar-C), 102.7 (C(3)H); m/z (-ES) 179 (100%, [M+H]- with 35Cl), 181 (35%, [M+H]- with 37Cl); found by +ES 179.0377, C9H8ClN2 ([M+H]+ with 35Cl), requires 179.0371, error 3.3 ppm.

7-Chloro-4-quinolinamine Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Chloro-4-quinolinamine Suppliers

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View Lastest Price from 7-Chloro-4-quinolinamine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
7-Chloro-4-quinolinamine 1198-40-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Shanghai kingmorn biotechnology Co.,LTD.
Product
7-Chloro-4-quinolinamine 1198-40-9
Price
US $0.00/g
Min. Order
10g
Purity
99%
Supply Ability
>100kg
Release date
2021-07-14
Career Henan Chemical Co
Product
7-Chloro-4-quinolinamine 1198-40-9
Price
US $1.00/g
Min. Order
1g
Purity
99.0%
Supply Ability
100kg
Release date
2020-01-09

1198-40-9, 7-Chloro-4-quinolinamineRelated Search:

Hydroxychloroquine Hydroxychloroquine sulfate Amodiaquin dihydrochloride dihydrate CHLOROQUINE Chloroquine diphosphate QUINACRINE MUSTARD DIHYDROCHLORIDE 1-GLYCERYL N-[7-CHLORO-4-QUINOLYL]ANTHRANILATE HYDROCHLORIDE Mepacrine hydrochloride 7-CHLOROQUINOLINE 5-CHLOROQUINOLIN-8-AMINE 7-CHLORO-4-HYDRAZINOQUINOLINE 6-CHLORO-9-[3-(2-CHLOROETHYLAMINO)PROPYLAMINO]-2-METHOXYACRIDINE DIHYDROCHLORIDE 2-(7-CHLOROQUINOLIN-4-YLAMINO)ETHANOL 6-CHLORO-9-[3-N-(2-CHLOROETHYL)ETHYLAMINO]PROPYLAMINO-2-METHOXYACRIDINE DIHYDROCHLORIDE 7-CHLORO-4-HYDRAZINO-2-METHYLQUINOLINE 7-CHLORO-2,8-DIMETHYL-4-HYDRAZINOQUINOLINE BUTTPARK 51\09-71 ACRIDINE HOMODIMER

  • BUTTPARK 22\09-04
  • 7-chloro-4-aminoquinoline
  • 4-amino-7-chloroQUINOLINE:7-chloro-4-quinolinamine
  • (7-chloro-4-quinolyl)amine
  • 4-QuinolinaMine,7-chloro-
  • 4-AMINO-7-CHLOROQUINOLINE
  • 7-CHLORO-QUINOLIN-4-YLAMINE
  • 7-chloro-4-quinolinamine
  • Hydroxychloroquine Impurity 34
  • 1198-40-9
  • pharmacetical