7-Chloro-4-quinolinamine

Product Name: 7-Chloro-4-quinolinamine
CAS No.: 1198-40-9
Chemical Name: 7-Chloro-4-quinolinamine
Synonyms: BUTTPARK 22\09-04;7-chloro-4-quinolinamine;7-chloro-4-aminoquinoline;4-AMINO-7-CHLOROQUINOLINE;4-QuinolinaMine,7-chloro-;(7-chloro-4-quinolyl)amine;7-CHLORO-QUINOLIN-4-YLAMINE;Hydroxychloroquine Impurity 34;4-amino-7-chloroQUINOLINE:7-chloro-4-quinolinamine
CBNumber: CB0199827
Molecular Formula: C9H7ClN2
Formula Weight: 178.62
MOL File: 1198-40-9.mol

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7-Chloro-4-quinolinamine Property

Melting point:: 150-152.5 °C
Boiling point:: 366.8±27.0 °C(Predicted)
Density: 1.363±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: solid
pka: 7.49±0.50(Predicted)
color: Off-white
CAS DataBase Reference: 1198-40-9(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 25-36
Safety Statements: 26-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BBO000159
Product name: 4-Amino-7-chloroquinoline
Purity: Aldrich
Packaging: 1g
Price: $320
Updated: 2024/03/01

TRC

Product number: C422285
Product name: 7-Chloroquinolin-4-amine
Packaging: 1g
Price: $415
Updated: 2021/12/16

TRC

Product number: C422285
Product name: 7-Chloroquinolin-4-amine
Packaging: 250mg
Price: $165
Updated: 2021/12/16

Apolloscientific

Product number: OR307952
Product name: 4-Amino-7-chloroquinoline
Packaging: 1g
Price: $185
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-5-3A
Product name: 4-Amino-7-chloroquinoline
Purity: 95%
Packaging: 1g
Price: $220
Updated: 2021/12/16

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7-Chloro-4-quinolinamine Chemical Properties,Usage,Production

Uses

7-Chloroquinolin-4-amine is an aminoquinoline that complexes ferriprotoporphyrin IX (Fe(III)PPIX) and inhibits its conversion to β-hematin (hemozoin).

Definition

ChEBI: 4-Amino-7-chloroquinoline is an aminoquinoline.

Synthesis Reference(s)

Journal of the American Chemical Society, 69, p. 704, 1947 DOI: 10.1021/ja01195a501

Synthesis

4-amino-7-chloroquinoline is obtained byreacting 7-chloro-4-hydrazinoquinoline ,sodium borohydride with nickel (II) chloride hexahydrate in methanol.To a suspension of 7-chloro-4-hydrazinoquinoline (1.67 g, 8.6 mmol) and nickel (II) chloride hexahydrate (2.00 g, 8.6 mmol) in methanol (33 ml), sodium borohydride (0.98 g, 25.8 mmol) was added cautiously while stirring the reaction mixture vigorously at room temperature and left to react overnight. The reaction mixture was filtered through celite pad. Water was used to dilute the filtrate layer and then washed with ethyl acetate. The organic layer was dried with magnesium sulphate and concentrated in vacuo to give the title compound as a yellow powder (1.09 g, 72%): mp: 143 – 147 ℃ (Lit.: 147 – 148 ℃) ;
vmax/cm-1 3337 s (N-H), 1642 m (C=N), 1609 m and 1575 m (C=N); δH (300 MHz; DMSO-d6) 8.28 (1H, d, J 5.3, C(2)H), 8.19 (1H, d, J 9.1, C(5)H), 7.76 (1H, d, J 1.6, C(8)H), 7.39 (1H, dd, J 9.1, 1.6, C(6)H), 7.03 (2H, s, NH2), 6.57 (1H, d, J 5.3, C(3)H); δC (75 MHz; DMSO-d6) 152.0 (Ar-C), 151.1 (C(2)H), 148.9 (Ar-C), 133.7 (Ar-C), 126.8 (C(8)H), 124.8 (C(5)H), 123.9 (C(6)H), 117.0 (Ar-C), 102.7 (C(3)H); m/z (-ES) 179 (100%, [M+H]- with 35Cl), 181 (35%, [M+H]- with 37Cl); found by +ES 179.0377, C9H8ClN2 ([M+H]+ with 35Cl), requires 179.0371, error 3.3 ppm.

7-Chloro-4-quinolinamine Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Chloro-4-quinolinamine Suppliers

Canada 1 China 69 France 1 Germany 1 India 2 Ukraine 1 United Kingdom 7 United States 20 Global 102

ABCR GmbH & CO. KG

Tel: --
Fax: --
Email: info@abcr.de
Country: Germany
ProdList: 6831
Advantage: 75

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View Lastest Price from 7-Chloro-4-quinolinamine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 7-Chloro-4-quinolinamine 1198-40-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Shanghai kingmorn biotechnology Co.,LTD.

Product: 7-Chloro-4-quinolinamine 1198-40-9
Price: US $0.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: >100kg
Release date: 2021-07-14

Career Henan Chemical Co

Product: 7-Chloro-4-quinolinamine 1198-40-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-09

1198-40-9, 7-Chloro-4-quinolinamineRelated Search:

Hydroxychloroquine Hydroxychloroquine sulfate Amodiaquin dihydrochloride dihydrate CHLOROQUINE Chloroquine diphosphate QUINACRINE MUSTARD DIHYDROCHLORIDE 1-GLYCERYL N-[7-CHLORO-4-QUINOLYL]ANTHRANILATE HYDROCHLORIDE Mepacrine hydrochloride 7-CHLOROQUINOLINE 5-CHLOROQUINOLIN-8-AMINE 7-CHLORO-4-HYDRAZINOQUINOLINE 6-CHLORO-9-[3-(2-CHLOROETHYLAMINO)PROPYLAMINO]-2-METHOXYACRIDINE DIHYDROCHLORIDE 2-(7-CHLOROQUINOLIN-4-YLAMINO)ETHANOL 6-CHLORO-9-[3-N-(2-CHLOROETHYL)ETHYLAMINO]PROPYLAMINO-2-METHOXYACRIDINE DIHYDROCHLORIDE 7-CHLORO-4-HYDRAZINO-2-METHYLQUINOLINE 7-CHLORO-2,8-DIMETHYL-4-HYDRAZINOQUINOLINE BUTTPARK 51\09-71 ACRIDINE HOMODIMER

BUTTPARK 22\09-04

7-chloro-4-aminoquinoline

4-amino-7-chloroQUINOLINE:7-chloro-4-quinolinamine

(7-chloro-4-quinolyl)amine

4-QuinolinaMine,7-chloro-

4-AMINO-7-CHLOROQUINOLINE

7-CHLORO-QUINOLIN-4-YLAMINE

7-chloro-4-quinolinamine

Hydroxychloroquine Impurity 34

1198-40-9

pharmacetical