Benzydamine hydrochloride
- Product Name
- Benzydamine hydrochloride
- CAS No.
- 132-69-4
- Chemical Name
- Benzydamine hydrochloride
- Synonyms
- af864;tamas;verax;tantum;riripen;ririlim;indolin;imotryl;Afloben;Alcidol
- CBNumber
- CB0204309
- Molecular Formula
- C19H23N3O.ClH
- Formula Weight
- 345.87
- MOL File
- 132-69-4.mol
Benzydamine hydrochloride Property
- Melting point:
- 147-153°C
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
- Water Solubility
- Soluble in water, ethanol, chloroform, n-butanol or DMSO /n
- Merck
- 14,1122
- InChIKey
- HNNIWKQLJSNAEQ-UHFFFAOYSA-N
- CAS DataBase Reference
- 132-69-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- NK7875000
- HS Code
- 2933.99.8290
- Toxicity
- LD50 in mice, rats (mg/kg): 110, 100 i.p.; 515, 1050 orally (Silvestrini)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B5524
- Product name
- Benzydamine hydrochloride
- Purity
- analytical standard
- Packaging
- 5g
- Price
- $53.9
- Updated
- 2024/03/01
- Product number
- B3751
- Product name
- Benzydamine Hydrochloride
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $30
- Updated
- 2024/03/01
- Product number
- B3751
- Product name
- Benzydamine Hydrochloride
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $91
- Updated
- 2024/03/01
- Product number
- J61180
- Product name
- Benzydamine hydrochloride
- Packaging
- 5g
- Price
- $33.65
- Updated
- 2024/03/01
- Product number
- J61180
- Product name
- Benzydamine hydrochloride
- Packaging
- 25g
- Price
- $108.65
- Updated
- 2024/03/01
Benzydamine hydrochloride Chemical Properties,Usage,Production
Description
Benzydamine hydrochloride is a non-steroidal antiinflammatory drug used both topically and systemically. It has been reported as a sensitizer and a photosensitizer and caused occupational contact dermatitis in a nurse.
Chemical Properties
Off-White Solid
Originator
Tantum,Angelini
Uses
A nonsteroidal anti-inflammatory drug with local anaesthetic, analgesic and antipyretic properties.
Uses
anticholinergic
Uses
A nonsteroidal anti-inflammatory with local anesthetic properties.
Uses
Benzydamine hydrochloride is an anti-in-flammatory drug used extensively in Europe and recently introduced in Canada to help re duce painful mucositis. Benzydamine provides short-term topical anesthesia and extended pain relief apparently through its anti-inflammatory properties. Studies have shown it to be effective in a range of painful conditions, including aphthous ulceration, chemotherapy-induced mucositis, and radiation-induced mucositis.
Definition
ChEBI: Benzydamine hydrochloride is a member of indazoles.
Manufacturing Process
To a solution of 175 g of anthranilic acid methyl ester in 2 L of water and 120
ml of concentrated hydrochloric acid at 25°C was added concentrated solution
of 80 g sodium nitrite. The product was dissolved in solution of 500 g NaOH in
1.5 L of water. To this solution under nitrogen was added 400 g of sodium
bisulfite. The mixture was stirred for 6 hours at 75°C under nitrogen. The
obtained solid product was dissolved in water and then to the solution was
added 750 ml glacial acetic acid. The yield of 1-benzyl-3-(3-(dimethylamino)
propoxy)-1H-indazole 70%, M.P. 154-156°C.
In practice it is usually used as monohydrochloride salt.
brand name
Tantum (Angelini Francesco, Italy).
Therapeutic Function
Analgesic, Antiinflammatory, Antipyretic
Contact allergens
It is a nonsteroidal anti-inflammatory drug used both topically and systemically. It has been reported as a sensitizer and a photosensitizer.
Side effects
The major side effects of benzydamine hydrochloride are oral numbness (reported prevalence: 10 percent), and oral burning/stinging (reported prevalence: 8 percent). Oral discomfort appears to be more of a problem in patients with extensive ulceration/infammation. The oral discomfort can sometimes be improved by diluting the benzydamine hydrochloride with an equal volume of water.It is thought that benzydamine hydrochloride does not precipitate peptic ulceration.
Safety Profile
Poison by intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion. An experimental teratogen. Other experimental animal reproductive effects. An eye irritant. A nonsteroidal antiinflammatory analgesic. When heated to decomposition it emits very toxic fumes of HCl and NOx.
Benzydamine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Benzydamine hydrochloride manufacturers
- Product
- Benzydamine hydrochloride 132-69-4
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99.0%-101.0%
- Supply Ability
- 1000 KGS
- Release date
- 2021-06-19
- Product
- Benzydamine hydrochloride 132-69-4
- Price
- US $19.00/KG
- Min. Order
- 1KG
- Purity
- 99.%
- Supply Ability
- 50 ton
- Release date
- 2024-08-23
- Product
- Benzydamine hydrochloride 132-69-4
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2024-08-19