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Benserazide hydrochloride

Product Name
Benserazide hydrochloride
CAS No.
14919-77-8
Chemical Name
Benserazide hydrochloride
Synonyms
BENSERAZIDE HCL;RO 4-4602;BENPARIZDE;31796-68-6;Ro 4-4602/001;NCGC00093698-03;SPECTRUM1500137;Benserazide hydrochlo;Benserazid hydrochloride;BENSERAZIDE HYDROCHLORIDE
CBNumber
CB4229025
Molecular Formula
C10H16ClN3O5
Formula Weight
293.7
MOL File
14919-77-8.mol
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Benserazide hydrochloride Property

Melting point:
146°C
storage temp. 
2-8°C
solubility 
H2O: 10 mg/mL
form 
solid
color 
White to Off-White
PH
pH(10g/L, 25℃) : 4.0～5.0
Water Solubility 
Soluble in water, dimethyl sulfoxide and methanol. Insoluble in ethanol and acetone.
Sensitive 
Light Sensitive
λmax
272nm(HCl aq.)(lit.)
Merck 
14,1050
InChIKey
ULFCBIUXQQYDEI-UHFFFAOYSA-N
CAS DataBase Reference
14919-77-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
2
RTECS 
VT9632300
HS Code 
29280000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0002115
Product name
Benserazide for peak identification A
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
Y0002115
Price
$150
Updated
2024/03/01
Sigma-Aldrich
Product number
B7283
Product name
Benserazide hydrochloride
Purity
≥98% (TLC), solid
Packaging
1g
Price
$120
Updated
2024/03/01
Sigma-Aldrich
Product number
BP685
Product name
Benserazide hydrochloride
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$275
Updated
2024/03/01
Sigma-Aldrich
Product number
B7283
Product name
Benserazide hydrochloride
Purity
≥98% (TLC), solid
Packaging
5g
Price
$417
Updated
2024/03/01
TCI Chemical
Product number
B4108
Product name
Benserazide Hydrochloride
Purity
>97.0%(HPLC)(T)
Packaging
1g
Price
$65
Updated
2024/03/01
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Benserazide hydrochloride Chemical Properties,Usage,Production

Description

Benserazide is an inhibitor of aromatic L-amino acid decarboxylase (AADC), an enzyme that has dopamine decarboxylase activity. It is also unable to cross the blood-brain barrier. As a result, benserazide blocks the conversion of L-DOPA to dopamine by AADC in the peripheral circulatory system. Benserazide is often combined with L-DOPA in patients with Parkinson’s disease.

Chemical Properties

White Crystalline Solid

Uses

Used as antiparkinsonian. A peripheral decarboxylase inhibitor

Uses

Antiparkinsonian;DOPA decarboxylase inhibitor

Uses

Inhibitor of L-aromatic amino acid decarboxylaseBenserazide hydrochloride is used as an antiparkinsonian. It is a peripheral decarboxylase inhibitor. It is used as an inhibitor for aromatic L-aminoacid decarboxylase. Further, it serves as an inhibitor of tyrosine hydroxylase (TH) and Tryptophan hydroxylase (TPH) inhibitor.

Definition

ChEBI: A hydrochloride that is the monohydrochloride salt of benserazide. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as an adjunct to levodopa in the treatment of park nsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide hydrochloride has no antiparkinson actions whe given alone.

General Description

Benserazide is a peripheral decarboxylase inhibitor.

Biochem/physiol Actions

Inhibitor of L-aromatic amino acid decarboxylase.

Benserazide hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Benserazide hydrochloride Suppliers

Americas 1 Belgium 1 Brazil 2 Canada 4 China 341 Europe 3 France 2 Germany 9 India 16 Japan 3 Philippines 1 Poland 1 South Korea 1 Spain 2 Sweden 1 Switzerland 3 United Kingdom 6 United States 44 Uruguay 1 Venezuela 1 Global 443
Yangzhou Aoxin Chemical Co., Ltd
Tel
0514-87754778 13901446058
Fax
+86-514-87752291
Email
sales@aochem.com
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China
ProdList
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Jinan Xuanzheng Pharmaceutical Co. LTD
Tel
18610218799
Email
xuanzhengyaoye@126.com
Country
China
ProdList
14
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58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
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3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
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Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
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TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
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021-67121385
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Sales-CN@TCIchemicals.com
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China
ProdList
24529
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ShangHai DEMO Chemical Co.,Ltd
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400-021-7337 2355568890
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0086-21-50182339
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sales@demochem.com
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China
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956
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0573-85285100
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isenchem@163.com
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China
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Adamas Reagent, Ltd.
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400-6009262 16621234537
Fax
021-64823266
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chenyj@titansci.com
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China
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14103
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View Lastest Price from Benserazide hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Benserazide hydrochloride 14919-77-8
Price
US $0.00/KG
Min. Order
1KG
Purity
98.5%~101.0%,EP
Supply Ability
800kg/month
Release date
2021-06-18
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Benserazide hydrochloride 14919-77-8
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-11-16
Hebei Zhanyao Biotechnology Co. Ltd
Product
Benserazide Hydrochloride 14919-77-8
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-12-22

14919-77-8, Benserazide hydrochlorideRelated Search:

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  • RO 4-4602
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  • BENSERAZIDE HYDROCHLORIDE EP2000
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  • Benserazide HCl (Serazide)
  • Benserazide HCl (Ro 4-4602)
  • (2RS)-2-Amino-3-hydroxy-2′-(2,3,4-trihydroxybenzyl)propanohydrazide hydrochloride
  • Benserazide hydrochloride, 98%, peripherally acting DOPA decarboxylase inhibitor
  • dl-serine 2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride
  • BENPARIZDE
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  • N'-(DL-Seryl)-N''-(2,3,4-trihydroxybenzyl)hydrazine hydrochloride
  • N-(DL-Seryl)-N'-(2,3,4-trihydroxybenzyl)hydrazine hydrochloride
  • Ro 4-4602/001
  • Serine, 2-(2,3,4-trihydroxybenzyl)hydrazide, monohydrochloride (8CI)
  • Serine, 2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide, monohydrochloride
  • 2-(2,3,4-TRIHYDROXYBENZYL)HYDRAZIDE
  • Benserazide hydrochloride(Benserazide HCl)
  • Benserazide hydrochloride (Serazide)
  • 2-AMino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide hydrochloride
  • N'-(2,3,4-trihydroxybenzyl)-2-amino-3-hydroxypropanehydrazide, hydrochloride(1:1)
  • (S)-2-Amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide hydrochloride
  • 31796-68-6
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  • Madopa (Hoffmann-LaRoche)
  • NCGC00093698-03
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  • 14919-77-8
  • 14064-64-1
  • 4919-77-8
  • C10H16ClN3O5
  • BioChemical
  • Biochemicals and Reagents
  • Aromatic amino acid decarboxylase, peripheral L-
  • A to C
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Enzyme