ChemicalBook > CAS DataBase List > Benserazide hydrochloride

Benserazide hydrochloride

Product Name
Benserazide hydrochloride
CAS No.
14919-77-8
Chemical Name
Benserazide hydrochloride
Synonyms
BENSERAZIDE HCL;RO 4-4602;BENPARIZDE;31796-68-6;Ro 4-4602/001;NCGC00093698-03;SPECTRUM1500137;Benserazide HCI;Benserazide hydrochlo;Benserazid hydrochloride
CBNumber
CB4229025
Molecular Formula
C10H16ClN3O5
Formula Weight
293.7
MOL File
14919-77-8.mol
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Benserazide hydrochloride Property

Melting point:
146°C
storage temp. 
2-8°C
solubility 
H2O: 10 mg/mL
form 
solid
color 
White to Off-White
PH
pH(10g/L, 25℃) : 4.0～5.0
biological source
synthetic
Water Solubility 
Soluble in water, dimethyl sulfoxide and methanol. Insoluble in ethanol and acetone.
Sensitive 
Light Sensitive
λmax
272nm(HCl aq.)(lit.)
Merck 
14,1050
InChI
InChI=1S/C10H15N3O5.ClH/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16;/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);1H
InChIKey
ULFCBIUXQQYDEI-UHFFFAOYSA-N
SMILES
C(NNCC1=CC=C(O)C(O)=C1O)(=O)C(CO)N.[H]Cl
CAS DataBase Reference
14919-77-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
2
RTECS 
VT9632300
HS Code 
29280000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0002115
Product name
Benserazide for peak identification A
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
10 mg
Price
$153
Updated
2025/07/31
Sigma-Aldrich
Product number
B7283
Product name
Benserazide hydrochloride
Purity
≥98% (TLC), solid
Packaging
1g
Price
$123
Updated
2025/07/31
Sigma-Aldrich
Product number
BP685
Product name
Benserazide hydrochloride
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$281
Updated
2025/07/31
Sigma-Aldrich
Product number
B7283
Product name
Benserazide hydrochloride
Purity
≥98% (TLC), solid
Packaging
5g
Price
$429
Updated
2025/07/31
Sigma-Aldrich
Product number
B0477000
Product name
Benserazide hydrochloride
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
50 mg
Price
$225
Updated
2025/07/31
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Benserazide hydrochloride Chemical Properties,Usage,Production

Description

Benserazide is an inhibitor of aromatic L-amino acid decarboxylase (AADC), an enzyme that has dopamine decarboxylase activity. It is also unable to cross the blood-brain barrier. As a result, benserazide blocks the conversion of L-DOPA to dopamine by AADC in the peripheral circulatory system. Benserazide is often combined with L-DOPA in patients with Parkinson’s disease.

Chemical Properties

White Crystalline Solid

Uses

Used as antiparkinsonian. A peripheral decarboxylase inhibitor

Uses

Antiparkinsonian;DOPA decarboxylase inhibitor

Uses

Inhibitor of L-aromatic amino acid decarboxylaseBenserazide hydrochloride is used as an antiparkinsonian. It is a peripheral decarboxylase inhibitor. It is used as an inhibitor for aromatic L-aminoacid decarboxylase. Further, it serves as an inhibitor of tyrosine hydroxylase (TH) and Tryptophan hydroxylase (TPH) inhibitor.

Definition

ChEBI: A hydrochloride that is the monohydrochloride salt of benserazide. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as an adjunct to levodopa in the treatment of park nsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide hydrochloride has no antiparkinson actions whe given alone.

General Description

Benserazide is a peripheral decarboxylase inhibitor.

Biochem/physiol Actions

Inhibitor of L-aromatic amino acid decarboxylase.

References

[1] SCHULTZ E. L-dopa as Substrate for human duodenal catechol-O-methyltransferase and aromatic L-amino acid decarboxylase[J]. Biomedical Chromatography, 1990, 4 6: 242-244. DOI: 10.1002/bmc.1130040607
[2] BENDER D A. Inhibition in vitro of the enzymes of the oxidative pathway of tryptophan metabolism and of nicotinamide nucleotide synthesis by benserazide, carbidopa and isoniazid[J]. Biochemical pharmacology, 1980, 29 5: Pages 707-712. DOI: 10.1016/0006-2952(80)90544-4
[3] WEI LI. Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2.[J]. ACS Chemical Biology, 2017: 58. DOI: 10.1186/s13046-017-0530-4
[4] HUO SHEN . Effects of benserazide on l-DOPA-derived extracellular dopamine levels and aromatic l-amino acid decarboxylase activity in the striatum of 6-hydroxydopamine-lesioned rats[J]. International congress series, 2003, 1251: Pages 199-204. DOI: 10.1016/s0531-5131(03)00119-5

Benserazide hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Benserazide hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Benserazide hydrochloride 14919-77-8
Price
US $0.00/KG
Min. Order
1KG
Purity
98.5%~101.0%,EP
Supply Ability
800kg/month
Release date
2021-06-18
Hebei Zhanyao Biotechnology Co. Ltd
Product
Benserazide Hydrochloride 14919-77-8
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-12-22
Hebei Zhanyao Biotechnology Co. Ltd
Product
Benserazide Hydrochloride 14919-77-8
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-12-28

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  • RO 4-4602
  • BENSERAZIDE HCL
  • BENSERAZIDE HYDROCHLORIDE
  • DL-SERINE 2[(2,3,4-TRIHYDROXYPHENYL)-METHYL] HYDRAZIDE HYDROCHLORIDE
  • DL-SERINE 2-[(2,3,4-TRIHYDROXYPHENYL)METHYL]HYDRAZIDE HCL
  • 2'-(2,3,4-trihydroxybenzyl)-dl-serinohydrazide monohydrochloride
  • 2-(2,3,4-trihydroxybenzyl)hydrazide,monohydrochloride,dl-serin
  • dl-serine,2-((2,3,4-trihydroxyphenyl)methyl)hydrazide,monohydrochloride
  • dl-serine2-(2,3,4-trihydroxybenzyl)hydrazinehydrochloride
  • BENSERAZIDE HYDROCHLORIDE EP2000
  • BENSERAZIDE HYDROCHLORIDE \ PERIPHERAL D
  • Benserazide HCl (Serazide)
  • Benserazide HCl (Ro 4-4602)
  • (2RS)-2-Amino-3-hydroxy-2′-(2,3,4-trihydroxybenzyl)propanohydrazide hydrochloride
  • Benserazide hydrochloride, 98%, peripherally acting DOPA decarboxylase inhibitor
  • dl-serine 2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride
  • BENPARIZDE
  • DL-Serine N2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride
  • N'-(DL-Seryl)-N''-(2,3,4-trihydroxybenzyl)hydrazine hydrochloride
  • N-(DL-Seryl)-N'-(2,3,4-trihydroxybenzyl)hydrazine hydrochloride
  • Ro 4-4602/001
  • Serine, 2-(2,3,4-trihydroxybenzyl)hydrazide, monohydrochloride (8CI)
  • Serine, 2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide, monohydrochloride
  • 2-(2,3,4-TRIHYDROXYBENZYL)HYDRAZIDE
  • Benserazide hydrochloride(Benserazide HCl)
  • Benserazide hydrochloride (Serazide)
  • N'-(2,3,4-trihydroxybenzyl)-2-amino-3-hydroxypropanehydrazide, hydrochloride(1:1)
  • (S)-2-Amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide hydrochloride
  • 31796-68-6
  • Benserazide hydrochlo
  • Madopa (Hoffmann-LaRoche)
  • NCGC00093698-03
  • SPECTRUM1500137
  • Benserazide hydrochioride
  • 2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanohydrazide hydrochloride
  • Benserazide Hydrochloride &gt
  • Benserazide hydrochloride CRS
  • Benserazide for peak identification CRS
  • Serine, 2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide, hydrochloride (1:1)
  • Benserazide hydrochloride USP/EP/BP
  • Benserazide D3 HydrochlorideQ: What is Benserazide D3 Hydrochloride Q: What is the CAS Number of Benserazide D3 Hydrochloride Q: What is the storage condition of Benserazide D3 Hydrochloride Q: What are the applications of Benserazide D3 Hydrochloride
  • Benserazide HydrochlorideQ: What is Benserazide Hydrochloride Q: What is the CAS Number of Benserazide Hydrochloride Q: What is the storage condition of Benserazide Hydrochloride Q: What are the applications of Benserazide Hydrochloride
  • Benserazid hydrochloride
  • Benserazide Hydrochloride, ≥ 97.0%
  • 2-Amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide hydrochloride
  • N'-(2,3,4-Trihydroxybenzyl)-(2S)-Benserazide-d3
  • Benzhydrazine hydrochloride
  • Benzyserazine hydrochloride
  • Benserazide hydrochloride-D3
  • Benserazide HCl - Bio-X ?
  • Benserazide HCI
  • D3- Benserazide Hydrochloride
  • 14919-77-8
  • 14064-64-1
  • 4919-77-8
  • 14919-18-9
  • C10H16ClN3O5
  • BioChemical