trans-Clomiphene Citrate
- Product Name
- trans-Clomiphene Citrate
- CAS No.
- 7599-79-3
- Chemical Name
- trans-Clomiphene Citrate
- Synonyms
- Enclomiphene citrate;Enclomifene citrate;Androxal;Enclomid;Unii-J303A6U9Y6;Clomiphene B citrate;(E)-Clomiphene citrate;tans-clomifene citrate;trans-clomifene citrate;trans-Clomiphene citrate
- CBNumber
- CB02079569
- Molecular Formula
- C32H36ClNO8
- Formula Weight
- 598.09
- MOL File
- 7599-79-3.mol
trans-Clomiphene Citrate Property
- Melting point:
- 143-145°C
- storage temp.
- Amber Vial, -20°C Freezer
- solubility
- DMSO (Slightly), Ethyl Acetate (Slightly, Heated, Sonicated)
- form
- Solid
- color
- White to Off-White
- Stability:
- Light Sensitive
- InChI
- InChI=1S/C26H28ClNO.C6H8O7/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,3-4,19-20H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25+;
- InChIKey
- PYTMYKVIJXPNBD-BTKVJIOYSA-N
- SMILES
- Cl/C(/C1C([H])=C([H])C([H])=C([H])C=1[H])=C(\C1C([H])=C([H])C([H])=C([H])C=1[H])/C1C([H])=C([H])C(=C([H])C=1[H])OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H].O([H])C(C(=O)O[H])(C([H])([H])C(=O)O[H])C([H])([H])C(=O)O[H]
N-Bromosuccinimide Price
- Product number
- C587045
- Product name
- trans-ClomipheneCitrate
- Packaging
- 10mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- API0018264
- Product name
- TRANS-EMCLOMIPHENE CITRATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $351.75
- Updated
- 2021/12/16
- Product number
- API0018264
- Product name
- TRANS-EMCLOMIPHENE CITRATE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1166.55
- Updated
- 2021/12/16
- Product number
- API0018264
- Product name
- TRANS-EMCLOMIPHENE CITRATE
- Purity
- 95.00%
- Packaging
- 100G
- Price
- $3326.4
- Updated
- 2021/12/16
- Product number
- DC8177
- Product name
- Enclomiphenecitrate
- Purity
- >98%
- Packaging
- 100mg
- Price
- $450
- Updated
- 2021/12/16
trans-Clomiphene Citrate Chemical Properties,Usage,Production
Chemical Properties
Enclomiphene citrate is chemically an organic citrate with good photoluminescent properties in organic solutions due to the presence of a tristyrene unit in its structure. Due to the presence of a tertiary amine unit in the structure, it is sensitive to oxidants and is easily oxidized by oxidants to the corresponding nitrogen oxides.
Uses
trans-Clomiphene Citrate, stereoisomer of Clomiphene Citrate (C587025), a synthetic estrogen agonist-antagonist. Gonad-stimulating principle.
Toxicology
The effects of the cis and trans isomers of clomiphene citrate on the uterine hexokinase activity of immature ovariectomized rats were studied in long- and short-term experiments. At a dose level of 600 μg/kg, both trans-Clomiphene Citrate and cis-Clomiphene Citrate caused a similar increase in total uterine hexokinase activity observable in 18 hr. When enzyme activity was expressed per g of the uterus (specific activity), significant increases were noted 18 hr after a single injection of trans clomiphene or after 4 daily injections of either isomer. Treatment of these animals with 170-estradiol (5 μg/kg) caused an elevation of both the specific and total hexokinase activities within 18 hr[1].
in vivo
Enclomiphene citrate (subcutaneous injection, 0.25 and 0.5 mg/animal, daily) inhibits spermatogenesis and decreases serum luteinizing hormone (LH) and testosterone levels in intact or castrated rats[5].
Enclomiphene citrate (oral adminstration, 0.03-3 mg/kg, daily for 90 days) reductes body weight to sham levels, and reduced serum cholesterol[6].
| Animal Model: | 21 days-old Charles River male rats[5] |
| Dosage: | 0.25 and 0.5 mg/animal, daily for 24 days. |
| Administration: | Subcutaneous injection |
| Result: | Decreased LH and testosterone levels in the serum. |
| Animal Model: | OVX (ovariectomy) rat model[6] |
| Dosage: | 0.03, 1, and 3 mg/kg, daily for 90 days. |
| Administration: | Oral adminstration |
| Result: | Reducted body weight to sham levels, and reduced serum cholesterol. Showed dose-dependent effects on the proximal tibia with BMD and BMC approaching posttreatment Sham levels. |
References
[1] D L DiPietro, D A Goss, F J Sanders. “Effect of cis and trans isomers of clomiphene citrate on uterine hexokinase activity.” Endocrinology 84 6 (1969): 1404–8.
trans-Clomiphene Citrate Preparation Products And Raw materials
Raw materials
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View Lastest Price from trans-Clomiphene Citrate manufacturers
- Product
- trans-Clomiphene Citrate 7599-79-3
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2025-11-11
- Product
- trans-Clomiphene Citrate 7599-79-3
- Price
- US $10.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 99%
- Supply Ability
- 1 ton
- Release date
- 2025-08-16
- Product
- Enclomiphene citrate 7599-79-3
- Price
- US $0.00-0.00/G
- Min. Order
- 10G
- Purity
- 99%
- Supply Ability
- 100G 1KG
- Release date
- 2025-05-20