KF31327

Product Name: KF31327
CAS No.: 220060-39-9
Chemical Name: KF31327
Synonyms: KF31327;Thioquinapiperfil;KF-31327 free base;Thioquinapiperifil;3-ethyl-8-[[2-[4-(hydroxymethyl)piperidin-1-yl]phenyl]methylamino]-1H-imidazo[4,5-g]quinazoline-2-thione;2H-Imidazo[4,5-g]quinazoline-2-thione, 3-ethyl-1,3-dihydro-8-[[[2-[4-(hydroxymethyl)-1-piperidinyl]phenyl]methyl]amino]-
CBNumber: CB02104148
Molecular Formula: C24H28N6OS
Formula Weight: 448.58
MOL File: 220060-39-9.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: INB0001267
Product name: KF31327
Purity: 95.00%
Packaging: 5MG
Price: $499.51
Updated: 2021/12/16

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KF31327 Chemical Properties,Usage,Production

Uses

Thioquinapiperifil (KF31327 free base), a potent, selective and non-competitive phosphodiesterase-5 (PDE-5, IC50 of 0.074 nM) inhibitor, is used for sexual enhancement study[1][2].

Biological Activity

Thioquinapiperifil (KF31327 free base) is a potent, selective, and noncompetitive inhibitor of phosphodiesterase (PDE-5) (IC50 of 0.074 nM) for sexual maturation studies.

in vitro

Thioquinapiperifil can be found in dietary supplements. Thioquinapiperifil (KF31327 free base) (0.1-10 μM) concentration dependently inhibits platelet aggregation. In the absence of nitroglycerin, higher concentrations 1 and 10 μM of Thioquinapiperifil (KF31327 free base) are required to inhibit platelet aggregation.

target

PDE5

0.074 nM (IC ₅₀ )

PDE1

380 nM (IC ₅₀ )

PDE2

670 nM (IC ₅₀ )

PDE3

38 nM ( IC ₅₀ )

PDE4

800 nM (IC ₅₀ )

IC 50

PDE5: 0.074 nM (IC₅₀); PDE1: 380 nM (IC₅₀); PDE2: 670 nM (IC₅₀); PDE3: 38 nM (IC₅₀); PDE4: 800 nM (IC₅₀)

References

[1] Nahoko Uchiyama, et al. Determination of a new type of phosphodiesterase-5 inhibitor, thioquinapiperifil, in a dietary supplement promoted for sexual enhancement. Chem Pharm Bull (Tokyo). 2008 Sep;56(9):1331-4. DOI:10.1248/cpb.56.1331
[2] R Hirose, et al. KF31327, a new potent and selective inhibitor of cyclic nucleotide phosphodiesterase 5. Eur J Pharmacol. 2001 Nov 9;431(1):17-24. DOI:10.1016/s0014-2999(01)01422-4

KF31327 Preparation Products And Raw materials

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KF31327 Suppliers

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220060-39-9, KF31327Related Search:

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KF31327

3-ethyl-8-[[2-[4-(hydroxymethyl)piperidin-1-yl]phenyl]methylamino]-1H-imidazo[4,5-g]quinazoline-2-thione

Thioquinapiperifil

2H-Imidazo[4,5-g]quinazoline-2-thione, 3-ethyl-1,3-dihydro-8-[[[2-[4-(hydroxymethyl)-1-piperidinyl]phenyl]methyl]amino]-

KF-31327 free base

Thioquinapiperfil

220060-39-9

C24H28N6OS