KF31327
- Product Name
- KF31327
- CAS No.
- 220060-39-9
- Chemical Name
- KF31327
- Synonyms
- KF31327;Thioquinapiperfil;KF-31327 free base;Thioquinapiperifil;3-ethyl-8-[[2-[4-(hydroxymethyl)piperidin-1-yl]phenyl]methylamino]-1H-imidazo[4,5-g]quinazoline-2-thione;2H-Imidazo[4,5-g]quinazoline-2-thione, 3-ethyl-1,3-dihydro-8-[[[2-[4-(hydroxymethyl)-1-piperidinyl]phenyl]methyl]amino]-
- CBNumber
- CB02104148
- Molecular Formula
- C24H28N6OS
- Formula Weight
- 448.58
- MOL File
- 220060-39-9.mol
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- INB0001267
- Product name
- KF31327
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.51
- Updated
- 2021/12/16
KF31327 Chemical Properties,Usage,Production
Uses
Thioquinapiperifil (KF31327 free base), a potent, selective and non-competitive phosphodiesterase-5 (PDE-5, IC50 of 0.074 nM) inhibitor, is used for sexual enhancement study[1][2].
Biological Activity
Thioquinapiperifil (KF31327 free base) is a potent, selective, and noncompetitive inhibitor of phosphodiesterase (PDE-5) (IC50 of 0.074 nM) for sexual maturation studies.
in vitro
Thioquinapiperifil can be found in dietary supplements. Thioquinapiperifil (KF31327 free base) (0.1-10 μM) concentration dependently inhibits platelet aggregation. In the absence of nitroglycerin, higher concentrations 1 and 10 μM of Thioquinapiperifil (KF31327 free base) are required to inhibit platelet aggregation.
target
| PDE5 0.074 nM (IC 50 ) | PDE1 380 nM (IC 50 ) | PDE2 670 nM (IC 50 ) | PDE3 38 nM ( IC 50 ) | PDE4 800 nM (IC 50 ) |
IC 50
PDE5: 0.074 nM (IC50); PDE1: 380 nM (IC50); PDE2: 670 nM (IC50); PDE3: 38 nM (IC50); PDE4: 800 nM (IC50)
References
[1] Nahoko Uchiyama, et al. Determination of a new type of phosphodiesterase-5 inhibitor, thioquinapiperifil, in a dietary supplement promoted for sexual enhancement. Chem Pharm Bull (Tokyo). 2008 Sep;56(9):1331-4. DOI:10.1248/cpb.56.1331
[2] R Hirose, et al. KF31327, a new potent and selective inhibitor of cyclic nucleotide phosphodiesterase 5. Eur J Pharmacol. 2001 Nov 9;431(1):17-24. DOI:10.1016/s0014-2999(01)01422-4
KF31327 Preparation Products And Raw materials
Raw materials
Preparation Products
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