PRE-084

Product Name: PRE-084
CAS No.: 138847-85-5
Chemical Name: PRE-084
Synonyms: I-AMB;PRE-084;J000280;BIMI1803;J-000280;4-MeO-PBP;BIMI-1803;PRE-084HCl;ZXAFC000547;ZX-AFC000547
CBNumber: CB0211068
Molecular Formula: C19H27NO3
Formula Weight: 317.42
MOL File: 138847-85-5.mol

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PRE-084 Property

Boiling point:: 446.6±40.0 °C(Predicted)
Density: 1.103±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: H₂O: ≤24 mg/mL
form: solid
pka: 5.99±0.10(Predicted)
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P2607
Product name: PRE-084
Purity: solid
Packaging: 10MG
Price: $162
Updated: 2024/03/01

Sigma-Aldrich

Product number: P2607
Product name: PRE-084
Purity: solid
Packaging: 50MG
Price: $724
Updated: 2024/03/01

Tocris

Product number: 0589
Product name: PRE-084hydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $162
Updated: 2021/12/16

Tocris

Product number: 0589
Product name: PRE-084hydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $670
Updated: 2021/12/16

Usbiological

Product number: 256320
Product name: PRE-084 hydrochloride
Packaging: 10mg
Price: $403
Updated: 2021/12/16

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PRE-084 Chemical Properties,Usage,Production

Description

PRE084 (138847-85-8) is an agonist of the σ receptor with selectivity for the σ1 subtype?(IC50’s: σ1 = 2.2nM, σ2 = 13091nM).1?PRE-084 has demonstrated neuroprotective/restorative effects in brain injury2,3?and neurodegenerative conditions4-7.

Definition

ChEBI: 1-phenyl-1-cyclohexanecarboxylic acid 2-(4-morpholinyl)ethyl ester is a member of morpholines.

Biological Activity

High affinity, selective σ 1 agonist (K i values are 2.2 and 13091 nM for σ 1 and σ 2 receptors respectively). Selective over PCP receptors (IC 50 > 100000 nM) and several other receptor systems. Produces antiamnesic and antitussive effects in vivo .

Biochem/physiol Actions

PRE-084 is a potent and highly selective σ1 opioid receptor agonist. It offers neuroprotection upon embolic stroke.

storage

Store at RT

References

1) Su?et al.?(1991),?Sigma compounds derived from phencyclidine. Identification of PRE-084, a new selective sigma ligand; J. Pharmacol. Exp. Ther.?259?543 2) Griesmaier?et al.?(2012),?Neuroprotective effects of the sigma-1 receptor ligand PRE-084 against excitotoxic perinatal brain injury in newborn mice; Exp. Neurol.?237?388 3) Dong?et al.?(2016),?Sigma-1 Receptor Modulates Neuroinflammation After Traumatic Brain Injury; Cell Mol. Neurobiol.?36?639 4) Guzman-Lenis?et al.?(2009),?Selective sigma receptor agonist 2-(4-Morpholinethyl) 1-phenylcyclohexanecarboxylate (PRE084) promotes neuroprotection and neurite elongation through protein kinase C (PKC) signaling on motoneurons; Neuroscience?162?31 5) Hyrskyluoto?et al.?(2013),?Sigma-1 receptor agonist PRE084 in protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-κB pathway; Cell Death Dis.?4?e646 6) Francardo?et al.?(2014),?Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism; Brain?137(Pt7)?1998 7) Mancuso?et al.?(2012),?Sigma-1R agonist improves motor function and motoneuron survival in ALS mice; Neurotherapeutics?9?814

PRE-084 Preparation Products And Raw materials

Raw materials

Preparation Products

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PRE-084 Suppliers

China 70 Denmark 1 Germany 3 India 1 Switzerland 1 United Kingdom 2 United States 11 USA 1 Global 90

Shanghai Boyle Chemical Co., Ltd.

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DeboraLabs

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Sigma-Aldrich

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EMMX Biotechnology LLC

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ShangHai Siyan Biological Technology Co., Ltd.

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Tianjin Kailiqi Biotechnology Co., Ltd.

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ShangHai Biochempartner Co.,Ltd

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Shanghai Chaolan Chemical Technology Center

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Amadis Chemical Company Limited

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138847-85-5, PRE-084Related Search:

MD-PHP 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE Vorinostat A 967079 VERATRIDINE 2-(3-fluorophenyl)-3-methylmorpholine(3-fluorophenmetrazine)(3-FPM) 5-METHOXY-2,3-DIHYDRO-1H-INDEN-2-AMINE α-Ethylaminopentiophenone (hydrochloride) P-NITROPHENYL PHOSPHATE 1-PHENYL-1-CYCLOHEXANECARBOXYLIC ACID butetamate Prospasmin PRE-084 2-(diethylamino)ethyl 2-phenylbutyrate hydrochloride (1-phenylcyclohexane)methanol 1-Phenylcyclohexanecarboxylic acid 2-(diethylamino)ethyl ester hydroch loride Cetamiphen 1-Phenylcyclohexane-1-carbaldehyde

2-(4-MORPHOLINETHYL)-1-PHENYLCYCLOHEXANECARBOXYLATE HCL

2-(4-MORPHOLINETHYL) 1-PHENYLCYCLOHEXANECARBOXYLATE HYDROCHLORIDE

PRE-084

PRE-084 HYDROCHLORIDE

PRE-084HCl

2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate

1-Phenylcyclohexanecarboxylic acid 2-morpholinoethyl ester

4-MeO-PBP

I-AMB

2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate

Cyclohexanecarboxylicacid, 1-phenyl-, 2-(4-morpholinyl)ethyl ester

PRE-084;PRE 084;PRE084

2-Morpholinoethyl 1-phenylcyclohexanecarboxylate

BIMI1803

BIMI-1803

J000280

J-000280

ZXAFC000547

ZX-AFC000547

138847-85-5

732121-92-1

C19H27NO3HCl

Sigma receptor

pharmaceuticals