PRE-084
- Product Name
- PRE-084
- CAS No.
- 138847-85-5
- Chemical Name
- PRE-084
- Synonyms
- I-AMB;PRE-084;J000280;BIMI1803;J-000280;4-MeO-PBP;BIMI-1803;PRE-084HCl;ZXAFC000547;ZX-AFC000547
- CBNumber
- CB0211068
- Molecular Formula
- C19H27NO3
- Formula Weight
- 317.42
- MOL File
- 138847-85-5.mol
PRE-084 Property
- Boiling point:
- 446.6±40.0 °C(Predicted)
- Density
- 1.103±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- H2O: ≤24 mg/mL
- form
- solid
- pka
- 5.99±0.10(Predicted)
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P2607
- Product name
- PRE-084
- Purity
- solid
- Packaging
- 10MG
- Price
- $162
- Updated
- 2024/03/01
- Product number
- P2607
- Product name
- PRE-084
- Purity
- solid
- Packaging
- 50MG
- Price
- $724
- Updated
- 2024/03/01
- Product number
- 0589
- Product name
- PRE-084hydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $162
- Updated
- 2021/12/16
- Product number
- 0589
- Product name
- PRE-084hydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $670
- Updated
- 2021/12/16
- Product number
- 256320
- Product name
- PRE-084 hydrochloride
- Packaging
- 10mg
- Price
- $403
- Updated
- 2021/12/16
PRE-084 Chemical Properties,Usage,Production
Description
PRE084 (138847-85-8) is an agonist of the σ receptor with selectivity for the σ1 subtype?(IC50’s: σ1 = 2.2nM, σ2 = 13091nM).1?PRE-084 has demonstrated neuroprotective/restorative effects in brain injury2,3?and neurodegenerative conditions4-7.
Definition
ChEBI: 1-phenyl-1-cyclohexanecarboxylic acid 2-(4-morpholinyl)ethyl ester is a member of morpholines.
Biological Activity
High affinity, selective σ 1 agonist (K i values are 2.2 and 13091 nM for σ 1 and σ 2 receptors respectively). Selective over PCP receptors (IC 50 > 100000 nM) and several other receptor systems. Produces antiamnesic and antitussive effects in vivo .
Biochem/physiol Actions
PRE-084 is a potent and highly selective σ1 opioid receptor agonist. It offers neuroprotection upon embolic stroke.
storage
Store at RT
References
1) Su?et al.?(1991),?Sigma compounds derived from phencyclidine. Identification of PRE-084, a new selective sigma ligand; J. Pharmacol. Exp. Ther.?259?543 2) Griesmaier?et al.?(2012),?Neuroprotective effects of the sigma-1 receptor ligand PRE-084 against excitotoxic perinatal brain injury in newborn mice; Exp. Neurol.?237?388 3) Dong?et al.?(2016),?Sigma-1 Receptor Modulates Neuroinflammation After Traumatic Brain Injury; Cell Mol. Neurobiol.?36?639 4) Guzman-Lenis?et al.?(2009),?Selective sigma receptor agonist 2-(4-Morpholinethyl) 1-phenylcyclohexanecarboxylate (PRE084) promotes neuroprotection and neurite elongation through protein kinase C (PKC) signaling on motoneurons; Neuroscience?162?31 5) Hyrskyluoto?et al.?(2013),?Sigma-1 receptor agonist PRE084 in protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-κB pathway; Cell Death Dis.?4?e646 6) Francardo?et al.?(2014),?Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism; Brain?137(Pt7)?1998 7) Mancuso?et al.?(2012),?Sigma-1R agonist improves motor function and motoneuron survival in ALS mice; Neurotherapeutics?9?814
PRE-084 Preparation Products And Raw materials
Raw materials
Preparation Products
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