(S)-4-Ethyl-4-hydroxy-11-[2-(isopropylamino)ethyl]-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione

Product Name: (S)-4-Ethyl-4-hydroxy-11-[2-(isopropylamino)ethyl]-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione
CAS No.: 256411-32-2
Chemical Name: (S)-4-Ethyl-4-hydroxy-11-[2-(isopropylamino)ethyl]-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione
Synonyms: Belotecan;CKD-602;Camtobell;CKD602/CAMTOBELL;BELOTECAN; CKD 602; CKD-602;LNHWXBUNXOXMRL-VWLOTQADSA-N;Belotecan (CKD602 free base);(S)-4-Ethyl-4-hydroxy-11-[2-(isopropylamino)ethyl]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-11-[2-[(1-methylethyl)amino]ethyl]-, (4S)-;(S)-4-Ethyl-4-hydroxy-11-[2-(isopropylamino)ethyl]-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione
CBNumber: CB02129578
Molecular Formula: C25H27N3O4
Formula Weight: 433.5
MOL File: 256411-32-2.mol

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(S)-4-Ethyl-4-hydroxy-11-[2-(isopropylamino)ethyl]-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione Property

Boiling point:: 772.4±60.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
pka: 11.24±0.20(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 5125
Product name: CKD602
Purity: ≥98%(HPLC)
Packaging: 50
Price: $200
Updated: 2021/12/16

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(S)-4-Ethyl-4-hydroxy-11-[2-(isopropylamino)ethyl]-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione Chemical Properties,Usage,Production

Uses

Antineoplastic (DNA topoisomerase I inhibitor).

Definition

ChEBI: Belotecan is a pyranoindolizinoquinoline.

in vivo

Belotecan (25 mg/kg; i.v. for 16 days at 4-day intervals) inhibits tumor growth in CaSki-xenografts nude mice^[1].

Animal Model:	BALB/c-nude mice with CaSki cells injection^[1]
Dosage:	25 mg/kg
Administration:	Intravenous injection; 25 mg/kg; 16 days at 4-day intervals
Result:	Significantly inhibited the tumor growth and showed no significant difference in bodyweight of xenograft mice and the controls.

(S)-4-Ethyl-4-hydroxy-11-[2-(isopropylamino)ethyl]-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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256411-32-2, (S)-4-Ethyl-4-hydroxy-11-[2-(isopropylamino)ethyl]-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dioneRelated Search:

ISOXADIFEN-ETHYL Ethanol Ethyl pyruvate Ethyl cyanoacetate Ethyl acrylate Ethyl formate CHLOROPHOSPHONAZO III Ethyl acetate Ethylparaben (S)-4-Ethyl-4-hydroxy-11-[2-(isopropylamino)ethyl]-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione

Camtobell

CKD-602

Belotecan

CKD602/CAMTOBELL

(S)-4-Ethyl-4-hydroxy-11-[2-(isopropylamino)ethyl]-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione

LNHWXBUNXOXMRL-VWLOTQADSA-N

BELOTECAN; CKD 602; CKD-602

1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-11-[2-[(1-methylethyl)amino]ethyl]-, (4S)-

Belotecan (CKD602 free base)

(S)-4-Ethyl-4-hydroxy-11-[2-(isopropylamino)ethyl]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

256411-32-2