ChemicalBook > CAS DataBase List > N-[2-[[[4-(2,2-Dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(S)-glycine monosodium salt

N-[2-[[[4-(2,2-Dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(S)-glycine monosodium salt

Product Name
N-[2-[[[4-(2,2-Dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(S)-glycine monosodium salt
CAS No.
150374-95-1
Chemical Name
N-[2-[[[4-(2,2-Dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(S)-glycine monosodium salt
Synonyms
ONO5046-Na;EI546 sodium;LY544349 sodium;SIVELESTAT SODIUM;Sodium sivelestat;Sivelestat sodium sa;Sivelestat sodium salt;Sivelestat SodiuM anhydrous;N-{2-[({4-[(2,2-Dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycinesodiumsalt;sodium,2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate
CBNumber
CB02131171
Molecular Formula
C20H21N2NaO7S
Formula Weight
456.44
MOL File
150374-95-1.mol
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N-[2-[[[4-(2,2-Dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(S)-glycine monosodium salt Property

Melting point:
104-108 °C(Solv: water (7732-18-5))
storage temp. 
Desiccate at RT
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
3535
Product name
Sivelestatsodiumsalt
Purity
≥98%(HPLC)
Packaging
10
Price
$125
Updated
2021/12/16
Tocris
Product number
3535
Product name
Sivelestatsodiumsalt
Purity
≥98%(HPLC)
Packaging
50
Price
$526
Updated
2021/12/16
TRC
Product number
S497060
Product name
SivelestatSodium
Packaging
5mg
Price
$50
Updated
2021/12/16
Usbiological
Product number
256675
Product name
Sivelestat sodium salt
Packaging
10mg
Price
$366
Updated
2021/12/16
ChemScene
Product number
CS-2920
Product name
Sivelestatsodium
Purity
99.13%
Packaging
10mg
Price
$84
Updated
2021/12/16
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N-[2-[[[4-(2,2-Dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(S)-glycine monosodium salt Chemical Properties,Usage,Production

Uses

Treatment of acute lung injury; acute respiratory distress syndrome (elastase inhibitor).

Uses

Sivelestat Sodium is an inhibitor of neutrophil elastase. Also, it is a promising therapeutic agent for severe acute pneumonitis caused by gefitinib.

Biological Activity

Selective leukocyte elastase inhibitor (IC 50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF- κ B activation and LTB 4 -induced neutrophil transmigration in vitro . Significantly attenuates ischemia-induced spinal cord injury, decreases serum cytokine levels and reduces acute inflammatory lung injury in vivo .

storage

Desiccate at RT

N-[2-[[[4-(2,2-Dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(S)-glycine monosodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[2-[[[4-(2,2-Dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(S)-glycine monosodium salt Suppliers

China 66 Sweden 1 United Kingdom 1 United States 9 Global 77
Tocris Bioscience
Tel
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Fax
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Email
customerservice@tocris.co.uk
Country
United Kingdom
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150374-95-1, N-[2-[[[4-(2,2-Dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(S)-glycine monosodium saltRelated Search:

ETHANE Chlorodimethylphenylsilane 4-Hydroxy-D-(-)-2-phenylglycine Benzoyl chloride Dimethyl sulfoxide Sulfuryl chloride Dimethyldimethoxysilane Sodium hydroxide Sodium citrate Sivelestat Sodium sulfate BENZOYL ISOCYANATE Dimethyl fumarate Diclofenac sodium Imipenem-Cilastatin sodium hydrate Diethoxydimethylsilane Montelukast sodium Sodium benzoate

  • n-[2-[[[4-(2,2-dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(s)-glycine monosodium salt
  • SIVELESTAT SODIUM
  • N-{2-[({4-[(2,2-Dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycinesodiumsalt
  • Sivelestat sodium salt
  • Glycine, N-[2-[[[4-(2,2-diMethyl-1-oxopropoxy)phenyl]sulfonyl]aMino]benzoyl]-, MonosodiuM salt
  • Sivelestat SodiuM anhydrous
  • sodium,2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate
  • sodium 2-[[[2-[[4-(2,2-dimethyl-1-oxopropoxy)phenyl]sulfonylamino]phenyl]-oxomethyl]amino]acetate
  • N-[2-[[[4-(2,2-Dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(S)-glycine monosodium salt USP/EP/BP
  • Sivelestat sodium sa
  • EI546 sodium
  • LY544349 sodium
  • ONO5046-Na
  • Sodium sivelestat
  • 150374-95-1
  • GYL