4-Aminophthalhydrazide
Uses- Product Name
- 4-Aminophthalhydrazide
- CAS No.
- 3682-14-2
- Chemical Name
- 4-Aminophthalhydrazide
- Synonyms
- ISOLUMINOL;IsoluMinol 4-Aminophthalhydrazid;4-AMINOPHTHALHYDRAZIDE;4-AMINOPHTHALOYLHYDRAZINE;6-Aminophthalazine-1,4-diol;4-Aminophthalic acid hydrazide;6-Amino-2,3-dihydro-1,4-phthal-;4-AMINOPHTHALHYDRAZIDE MONOHYDRATE;4-AMINOPHTHALHYDRAZIDE HYDRATE, 98%
- CBNumber
- CB0214221
- Molecular Formula
- C8H7N3O2
- Formula Weight
- 177.16
- MOL File
- 3682-14-2.mol
4-Aminophthalhydrazide Property
- Melting point:
- 300 °C (lit.)
- Density
- 1.433±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Soluble in ammonium hydroxide, sodium carbonate or other base.
- pka
- 10.78±0.20(Predicted)
- form
- Solid
- color
- White to Off-White
- Sensitive
- Air Sensitive
- BRN
- 164804
- InChI
- InChI=1S/C8H7N3O2/c9-4-1-2-5-6(3-4)8(13)11-10-7(5)12/h1-3H,9H2,(H,10,12)(H,11,13)
- InChIKey
- HUDPLKWXRLNSPC-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=CC(N)=C2)C(O)=NN1
- CAS DataBase Reference
- 3682-14-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A8264
- Product name
- 4-Aminophthalhydrazide
- Packaging
- 1g
- Price
- $161
- Updated
- 2025/07/31
- Product number
- A8264
- Product name
- 4-Aminophthalhydrazide
- Packaging
- 5g
- Price
- $605
- Updated
- 2025/07/31
- Product number
- A5300
- Product name
- Isoluminol [Chemiluminescence reagent]
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $99
- Updated
- 2025/07/31
- Product number
- A5300
- Product name
- Isoluminol [Chemiluminescence reagent]
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 10g
- Price
- $594
- Updated
- 2025/07/31
- Product number
- A8264
- Product name
- 4-Aminophthalhydrazide
- Packaging
- 10g
- Price
- $945
- Updated
- 2025/07/31
4-Aminophthalhydrazide Chemical Properties,Usage,Production
Uses
4-Aminophthalhydrazide is a chemiluminescent compound.
Chemical Properties
Powder
Uses
4-Aminophthalhydrazide has been used in:
- chemiluminescence-based reactive oxygen species (ROS) assay in bone marrow (BM) neutrophils post-Yersinia pseudotuberculosis infection
- neutrophil ROS assays post-K. pneumonia exposure
- neutrophil ROS assays in response to formylated-methionine-leucine-proline
Biochem/physiol Actions
4-Aminophthalhydrazide or isoluminol is a chemiluminescent compound that comprises a phthalazine ring. It is more hydrophilic than luminol. Isoluminol is commercially used in a wide variety of in vitro immunoassays and is a chemiluminescence amplifier for studying reactive oxygen species. It is also useful as an electroluminescence (ECL) biosensor and as a probe for rapid microbial detection.
Synthesis
3682-19-7
3682-14-2
The general procedure for the synthesis of 4-amino phthalazine hydrazide using 6-nitro-2,3-dihydrophthalazine-1,4-dione as starting material was as follows: Intermediate B was transferred to a 5L high-pressure hydrogenation reactor and 3 g of 10% palladium/carbon catalyst was added. The reaction system was heated to 35 ℃ and hydrogen was introduced until the pressure reached 4 atm, and the reaction was maintained at a constant pressure for 4 h. After the reaction was completed, the reaction was carried out with nitrogen. Upon completion of the reaction, the hydrogen in the reactor was replaced with nitrogen. Subsequently, the pH of the reaction solution was adjusted to 3-4 with 35% by weight concentrated hydrochloric acid. heating was continued to 100°C and the nitrogen gas flow was stopped. The reaction mixture was filtered while hot and the filtrate precipitated a large amount of solid after cooling to room temperature. The solid precipitate was collected by filtration and the filtrate could be used for organic solvent recovery. The resulting filter cake was washed with 400 ml of deionized water and dried to give 214 g of 4-amino phthalic hydrazide (isluminolide).
References
[1] Patent: CN106810501, 2017, A. Location in patent: Paragraph 0050
[2] Journal of the Chemical Society, 1937, p. 26,31
[3] Recueil des Travaux Chimiques des Pays-Bas, 1935, vol. 54, p. 471
[4] Bulet.Soc.Chim.Romania, 1930, vol. 12, p. 140,163
[5] Patent: CN105348202, 2016, A. Location in patent: Paragraph 0045; 0054; 0055; 0056
4-Aminophthalhydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Aminophthalhydrazide manufacturers
- Product
- 4-Aminophthalhydrazide (Isoluminol) 3682-14-2
- Price
- US $320.00/Kg/Drum
- Min. Order
- 5Kg/Drum
- Purity
- 99.00%HPLC
- Supply Ability
- 8.5tons/month
- Release date
- 2021-09-14
- Product
- 4-Aminophthalhydrazide 3682-14-2
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-07-19
- Product
- Isoluminol | 4-aminophthaloyl hydrazide 3682-14-2
- Price
- US $12.00-4.50/G
- Min. Order
- 10g
- Purity
- ＞98%
- Supply Ability
- 100kg
- Release date
- 2020-11-03