4-PHENOXYPHENYLACETIC ACID
- Product Name
- 4-PHENOXYPHENYLACETIC ACID
- CAS No.
- 6328-74-1
- Chemical Name
- 4-PHENOXYPHENYLACETIC ACID
- Synonyms
- NSC 43857;RARECHEM AL BO 1521;4-PHENOXYPHENYLACETIC;4-PHENOXYPHENYLACETIC ACID;p-Phenoxyphenylacetic Acid;4-Phenoxybenzeneacetic Acid;4-Phenoxyphenylethanoic acid;p-Phenyloxyphenylacetic Acid;4-Phenoxyphenylacetic acid 97%;2-(4-PHENOXYPHENYL)ACETIC ACID
- CBNumber
- CB0217297
- Molecular Formula
- C14H12O3
- Formula Weight
- 228.24
- MOL File
- 6328-74-1.mol
4-PHENOXYPHENYLACETIC ACID Property
- Melting point:
- 72-79 °C
- Boiling point:
- 382℃
- Density
- 1.217
- refractive index
- 1.5800 (estimate)
- Flash point:
- 146℃
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 4.34±0.10(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 6328-74-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H318Causes serious eye damage
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 665053
- Product name
- 4-Phenoxyphenylacetic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $44
- Updated
- 2023/06/20
- Product number
- 665053
- Product name
- 4-Phenoxyphenylacetic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $209
- Updated
- 2023/06/20
- Product number
- P318810
- Product name
- p-PhenyloxyphenylaceticAcid
- Packaging
- 50mg
- Price
- $1320
- Updated
- 2021/12/16
- Product number
- 019411
- Product name
- p-Phenyloxyphenylacetic Acid
- Packaging
- 5mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- 2721-1-45
- Product name
- 4-Phenoxyphenylacetic acid
- Purity
- 98%
- Packaging
- 5G
- Price
- $324
- Updated
- 2021/12/16
4-PHENOXYPHENYLACETIC ACID Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
p-Phenyloxyphenylacetic Acid is an arylaliphatic acid used in the preperation of protential inhibitors of collagen-induced aggregation of human thrombocytes. p-Phenyloxyphenylacetic Acid is a predicted metabolite of 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline (A621350).
Uses
4-PHENOXYPHENYLACETIC ACID is an arylaliphatic acid used in the preperation of protential inhibitors of collagen-induced aggregation of human thrombocytes. p-Phenyloxyphenylacetic Acid is a predicted metabolite of 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline.
Synthesis
4664-61-3
6328-74-1
General procedure for the synthesis of 4-phenoxyphenylacetic acid from methyl 2-(4-phenoxyphenyl)acetate: 1N aqueous NaOH solution (7.8 mL) was added to a solution of methyl 4-phenoxyphenylacetate (948 mg, 3.9 mmol) in ethanol (20 mL), and the reaction was stirred at room temperature for 5 hours. After completion of the reaction, the reaction solution was concentrated under reduced pressure and acidified by adding 1N aqueous hydrochloric acid (10 mL). The precipitated white solid was collected by filtration and washed with water and ether sequentially to afford 4-phenoxyphenylacetic acid (813 mg, 91% yield) as a white solid. The product was detected by LC-MS showing m/z 229 [M + H]+, and 1H-NMR (300 MHz, CDCl3) data were as follows: δ 6.91-7.01 (m, 4H), 7.10-7.14 (t, J = 6.6 Hz, 1H), 7.25-7.28 (d, J = 8.4 Hz, 2H), 7.35-7.41 (m, 2H) .
References
[1] Patent: EP1849465, 2007, A1. Location in patent: Page/Page column 139
[2] Chemical and pharmaceutical bulletin, 1965, vol. 13, # 11, p. 1341 - 1345
[3] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 13, p. 3695 - 3700
4-PHENOXYPHENYLACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
4-PHENOXYPHENYLACETIC ACID Suppliers
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- Country
- Switzerland
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View Lastest Price from 4-PHENOXYPHENYLACETIC ACID manufacturers
- Product
- 4-PHENOXYPHENYLACETIC ACID 6328-74-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 4-PHENOXYPHENYLACETIC ACID 6328-74-1
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-08-20