ChemicalBook > CAS DataBase List > ELEUTHEROSIDE B

ELEUTHEROSIDE B

Product Name
ELEUTHEROSIDE B
CAS No.
118-34-3
Chemical Name
ELEUTHEROSIDE B
Synonyms
SYRINGIN;LIGUSTRIN;Alyposide;SYRINGOSIDE;Syrigin,Syrigin,Eleutheroside B;ILACIN;SYRINGINE;(E)-Syringin;Ilexanthin A;Magnolenin A
CBNumber
CB0217631
Molecular Formula
C17H24O9
Formula Weight
372.37
MOL File
118-34-3.mol
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ELEUTHEROSIDE B Property

Melting point:
192°C
Boiling point:
421.84°C (rough estimate)
Density 
1.2870 (rough estimate)
refractive index 
1.6230 (estimate)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly)
form 
Solid
pka
12.75±0.70(Predicted)
color 
White to Off-White
BRN 
97166
InChI
InChI=1S/C17H24O9/c1-23-10-6-9(4-3-5-18)7-11(24-2)16(10)26-17-15(22)14(21)13(20)12(8-19)25-17/h3-4,6-7,12-15,17-22H,5,8H2,1-2H3/b4-3+/t12-,13-,14+,15-,17+/m1/s1
InChIKey
QJVXKWHHAMZTBY-GCPOEHJPSA-N
SMILES
O([C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)C1C(=CC(=CC=1OC)/C=C/CO)OC
LogP
-1.550 (est)
CAS DataBase Reference
118-34-3
EPA Substance Registry System
Syringin (118-34-3)
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Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL89189
Product name
Eleutheroside B
Purity
phyproof? Reference Substance
Packaging
10MG
Price
$650
Updated
2025/07/31
Sigma-Aldrich
Product number
90974
Product name
Eleutheroside B
Purity
analytical standard
Packaging
10mg
Price
$643
Updated
2025/07/31
Sigma-Aldrich
Product number
1234668
Product name
Eleutheroside B
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
15mg
Price
$1640
Updated
2025/07/31
TCI Chemical
Product number
Y0030
Product name
Syringin
Packaging
10MG
Price
$140
Updated
2025/07/31
TCI Chemical
Product number
Y0030
Product name
Syringin
Packaging
50MG
Price
$420
Updated
2025/07/31
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ELEUTHEROSIDE B Chemical Properties,Usage,Production

Description

Syringin is a phenylpropanoid glycoside first isolated from A. senticosus that enhances acetylcholine release in pancreatic cells leading to an increase in insulin release through the muscarinic M3 receptor. Syringin dose-dependently (50, 75, and 100 μg/kg, i.v.) decreases plasma glucose levels and increases insulin-like immunoreactivity and C-peptide in rats, and these effects last at least 60 minutes. In a rat model of type 1 diabetes, it decreases plasma glucose and increases β-endorphin release from the adrenal medulla. Syringin increases autophagy through AMP-activated protein kinase α (AMPKα) activation concomitant with preventing the progression of cardiac hypertrophy in mice following aortic banding. It also has immunomodulatory effects, likely due to its metabolite sinapyl alcohol.

Chemical Properties

Off-White Solid

Uses

Syringin is a chemical that is found naturally in various plants such as Araliaceae, a adaptogenic agent with Syringin as the active componet. Syringin have exhibited the ability to enhance glucose utilization and the lowering of plasma glucose level in rats suffering from insulin deficiency, suggesting that this chemical may be useful in the treatment of human diabetes.

Definition

ChEBI: Syringin is a monosaccharide derivative that is trans-sinapyl alcohol attached to a beta-D-glucopyranosyl residue at position 1 via a glycosidic linkage. It has a role as a hepatoprotective agent and a plant metabolite. It is a beta-D-glucoside, a monosaccharide derivative, a primary alcohol and a dimethoxybenzene. It is functionally related to a trans-sinapyl alcohol.

in vivo

Animal Model:Sixty female ICR mice (24 g) bearing ovariectomized[1]
Dosage:10 mg/kg, 20 mg/kg and 40 mg/kg
Administration:Orally active, daily, 12 weeks
Result:Significantly improved the BMD, bone maximum load and trabecular bone microarchitecture in ovariectomized mice.

References

[1] SANJAY SHARMA. Review on Chemistry, Analysis and Pharmacology of Teneligliptin: A Novel DPP-4 Inhibitor.[J]. Mini reviews in medicinal chemistry, 2020, 20 12: 1091-1100. DOI: 10.2174/1389557520666200228144148
[2] KO YU LIU . Release of acetylcholine by syringin, an active principle of Eleutherococcus senticosus, to raise insulin secretion in Wistar rats[J]. Neuroscience Letters, 2008, 434 2: Pages 195-199. DOI: 10.1016/j.neulet.2008.01.054
[3] H-S NIU. Increase of beta-endorphin secretion by syringin, an active principle of Eleutherococcus senticosus, to produce antihyperglycemic action in type 1-like diabetic rats.[J]. Hormone and Metabolic Research, 2007, 39 12: 894-898. DOI: 10.1055/s-2007-993154
[4] FANGFANG LI. Syringin prevents cardiac hypertrophy induced by pressure overload through the attenuation of autophagy.[J]. International journal of molecular medicine, 2016, 39 1 1: 199-207. DOI: 10.3892/ijmm.2016.2824
[5] JONGWON CHOI. Anti-inflammatory and antinociceptive effects of sinapyl alcohol and its glucoside syringin.[J]. Planta medica, 2004, 70 11: 1027-1032. DOI: 10.1055/s-2004-832642

ELEUTHEROSIDE B Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ELEUTHEROSIDE B manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Syringin 118-34-3
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-10-28
Career Henan Chemical Co
Product
ELEUTHEROSIDE B 118-34-3
Price
US $29.00/KG
Min. Order
25KG
Purity
99%
Supply Ability
10000kg
Release date
2018-07-27

118-34-3, ELEUTHEROSIDE BRelated Search:


  • SYRINGIN
  • SYRINGINE
  • SYRINGOSIDE
  • LIGUSTRIN
  • ILACIN
  • ELEUTHEROSIDE B
  • Ciwujianoside-B(ELEUTHEROSIDE B)
  • Syringin (eleutheroside B)
  • Eleutheroside B (15 mg) (Syringin)
  • SYRINGIN(SEE ELEUTHEROSIDE B)(P)
  • Syrigin,Syrigin,Eleutheroside B
  • (E)-Syringin
  • [4-[(E)-3-Hydroxy-1-propenyl]-2,6-dimethoxyphenyl]β-D-glucopyranoside
  • 2,6-Dimethoxy-4-[(E)-3-hydroxy-1-propenyl]phenyl β-D-glucopyranoside
  • 4-[(E)-3-Hydroxy-1-propenyl]-2,6-dimethoxyphenyl β-D-glucopyranoside
  • O-Glucosyl synapyl alcohol
  • (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-[4-[(E)-3-hydroxyprop-1-enyl]-2,6-dimethoxyphenoxy]oxane-3,4,5-triol
  • Alyposide
  • Ilexanthin A
  • Magnolenin A
  • Methoxyconiferin
  • 4-[(1E)-3-Hydroxyprop-1-en-1-yl]-2,6-diMethoxyphenylβ-D-glucopyranoside
  • Eleutheroside B, 98%, from Acanthopanax
  • (E)-4-[-3-Hydroxy-1-propenyl]-2,6-dimethoxyphenyl-β-D-glucopyranoside
  • Methoxyconiferine
  • St. Johns Wort Extract (Standard)
  • Eleutheroside B Standard
  • β-D-Glucopyranoside, 4-[(1E)-3-hydroxy-1-propen-1-yl]-2,6-dimethoxyphenyl
  • ELEUTHEROSIDE B USP/EP/BP
  • TIANFU CHEM--ELEUTHEROSIDE B
  • (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(4-((E)-3-hydroxyprop-1-en-1-yl)-2,6-dimethoxyphenoxy)tetrahydro-2H-pyran-3,4,5-triol
  • Syringin (6CI, 7CI, 8CI)
  • Eleutheroside B-RM
  • 118-34-3
  • C17H24O9
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Phenylpropanoids
  • Standardized plant extract
  • Cardioglycosides & Glycosides