ChemicalBook > CAS DataBase List > Rutaecarpine

Rutaecarpine

Product Name
Rutaecarpine
CAS No.
84-26-4
Chemical Name
Rutaecarpine
Synonyms
RUTECARPINE;Rutacarpine;RHETINE;Rutaecarpine;Rutaccarpine;Rutaecarpine;RUTECARPINE 95+;Rutaecarpine-RM;Rutaecarpine >Rutaecarpine std.
CBNumber
CB0226965
Molecular Formula
C18H13N3O
Formula Weight
287.32
MOL File
84-26-4.mol
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Rutaecarpine Property

Melting point:
259.5-260°
Boiling point:
429.62°C (rough estimate)
Density 
1.2030 (rough estimate)
refractive index 
1.5855 (estimate)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO: 18 mg/mL clear yellow solution, soluble
form 
solid
pka
15.79±0.20(Predicted)
color 
white
Merck 
14,8298
InChI
InChI=1S/C18H13N3O/c22-18-13-6-2-4-8-15(13)20-17-16-12(9-10-21(17)18)11-5-1-3-7-14(11)19-16/h1-8,19H,9-10H2
InChIKey
ACVGWSKVRYFWRP-UHFFFAOYSA-N
SMILES
N1C2=C(C=CC=C2)C(=O)N2CCC3C4=C(NC=3C=12)C=CC=C4
CAS DataBase Reference
84-26-4(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
25-36/37/38
Safety Statements 
45-36-26
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
NM3454000
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
R3277
Product name
Rutaecarpine
Purity
>98% (HPLC)
Packaging
5mg
Price
$86
Updated
2025/07/31
Sigma-Aldrich
Product number
R3277
Product name
Rutaecarpine
Purity
>98% (HPLC)
Packaging
25mg
Price
$673
Updated
2025/07/31
Sigma-Aldrich
Product number
PHL89319
Product name
Rutaecarpine
Purity
phyproof<SUP>&#174;</SUP> Reference Substance
Packaging
10 mg
Price
$229
Updated
2025/07/31
TCI Chemical
Product number
R0102
Product name
Rutaecarpine
Purity
>98.0%(HPLC)(N)
Packaging
200mg
Price
$198
Updated
2025/07/31
Cayman Chemical
Product number
22897
Product name
Rutaecarpine
Purity
≥98%
Packaging
5mg
Price
$49
Updated
2024/03/01
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Rutaecarpine Chemical Properties,Usage,Production

Description

This alkaloid occurs with Evodiamine (q.v.) in the Chinese drug 'Wou-chou-yu' which is the dried fruit of Evodia rutaecarpa Benth. It crystallizes from boiling EtOH as colourless, or pale yellow, needles and is optically inactive. The acetyl derivative has m.p. 184-6°C and the benzoyl compound, m.p. 194°C. The alkaloid gives a yellow colour with concentrated H2S04 and is decomposed by KOH in boiling amyl alcohol yielding anthranilic acid and 3-{3-aminoethylindole- 2-O!carboxylic acid, CllH120 2N2, silky crystals, m.p. 257°C.
Pharmacologically, the alkaloid causes increased arterial pressure on injection.

Chemical Properties

Solid

Uses

Rutaecarpine is an indole alkaloid contained in the fruit of Evodiae fruits. It been shown to ameliorate bodyweight gain through orexigenic neuropeptides NPY and AgRP. It also playes a role in the treatment of high blood pressure

Definition

ChEBI: Rutecarpine is a member of beta-carbolines.

in vivo

Rutaecarpine showed in vivo anti-inflammatory activity on rat l-carrageenan induced paw edema by intraperitoneal administration[1]. Rutaecarpine significantly decreases the number of antibody-forming cells and causes weight decrease in spleen in a dose-dependent manner. In addition, rutaecarpine administered mice exhibit reduced splenic cellularity, decreased numbers of total T cells, CD4+ cells, CD8+ cells, and B cells in spleen. IL-2, interferon and IL-10 mRNA expressions are suppressed significantly by rutaecarpine treatment. The number of CD4+IL-2+ cells is reduced significantly following administration of mice with rutaecarpine[3].

IC 50

COX-2: 0.28 μM (IC50, in BMMC); COX-1: 8.7 μM (IC50, in BMMC)

References

Asahina, Kashiwagi., J. Pharm. Chim., 14,54 (1916)
Asahina, Mayeda.,J. Pharm. Soc., Japan, No. 416 (1916)
Asahina, Fujita., ibid, 863 (1921)
Kermack, Perkin, Robinson.,J. Chem. Soc., 119,1615 (1921)
Asahina, Manske, Robinson., ibid, 1708 (1927)
Asahina, Irie, Ohta., J. Pharm. Soc., Japan, 48, 51 (1928)
Ohta., ibid, 60, 109 (1940)
Schopf, Steuer., Annalen, 558, 124 (1947)
Biosynthesis:
Yamazaki, Ikuta., Tetrahedron Lett., 3221 (1966)
Yamazakietal., ibid, 3317 (1967)
Pharmacology:
Raymond-Hamet., Cornpt. rend., 220, 749 (1945)

Rutaecarpine Preparation Products And Raw materials

Raw materials

Preparation Products

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Rutaecarpine Suppliers

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View Lastest Price from Rutaecarpine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Rutaecarpine 84-26-4
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98%min HPLC
Supply Ability
100kg
Release date
2021-09-15
Henan Aochuang Chemical Co.,Ltd.
Product
Rutaecarpine 84-26-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-29
Dingwang Technology (Wuhan) Co., Ltd.
Product
Rutaecarpine 84-26-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2022-11-02

84-26-4, RutaecarpineRelated Search:

Hydroxyevodiamine Evodiamine CASTICIN Rutaevin 7-acetate EUDESMINE evocarpine Fructus Evodiae Polysaccharide Schisandrin WUWEIZISU C Crocin 1-[(2E,4E,6E,8E,10E,12E,14E)-b-D-glucopyranosyl 2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate] 6-O-b-D-glucopyranosyl-b-D-Glucopyranose 2α,19α－Dihydroxyursolic acid 6-(2-O-alpha-L-Arabinopyranosyl-beta-D-glucopyranosyl)-2-[4-(beta-D-glucopyranosyloxy)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one schisanhenol KU-55933 (ATM Kinase Inhibitor) Rutin Gefitinib Stigmasterol

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