Erdosteine

ChemicalBook > CAS DataBase List > Erdosteine

Product Name: Erdosteine
CAS No.: 84611-23-4
Chemical Name: Erdosteine
Synonyms: pv144;RV-144;KW-9144;Erdosten;Erdostiene;ERDOSTEINE;Dithiosteine;Erdosteine>ERDOSTEINE BP98;Erdosteine, ≥ 98.0%
CBNumber: CB0230173
Molecular Formula: C8H11NO4S2
Formula Weight: 249.31
MOL File: 84611-23-4.mol

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Erdosteine Property

Melting point:: 156-160°C
Boiling point:: 590.4±50.0 °C(Predicted)
Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: 3.71(at 25℃)
form: Solid
color: White to Off-White
λmax: 236nm(H2O)(lit.)
Merck: 14,3647
InChIKey: QGFORSXNKQLDNO-UHFFFAOYSA-N
CAS DataBase Reference: 84611-23-4(CAS DataBase Reference)

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Safety

RTECS: AJ1476200
HS Code: 2934.99.9001
Toxicity: LD50 in mice and rats (g/kg): >10 orally; >3.5 i.v. (Gonella)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: E1026
Product name: Erdosteine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $51
Updated: 2024/03/01

TCI Chemical

Product number: E1026
Product name: Erdosteine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 29177
Product name: Erdosteine
Packaging: 1g
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 29177
Product name: Erdosteine
Packaging: 25g
Price: $1201
Updated: 2024/03/01

Cayman Chemical

Product number: 29177
Product name: Erdosteine
Packaging: 5g
Price: $362
Updated: 2024/03/01

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Erdosteine Chemical Properties,Usage,Production

Description

Erdosteine is a new expectorant introduced in France for the treatment of chronic bronchitis. Erdosteine possesses mucomodulator, mucolytic, mucokinetic and free radical scavenging properties. Its therapeutic efficacy has been demonstrated in patients affected by congestion and viscous mucus in higher and lower respiratory tracts as in acute and chronic bronchitis, sinusitis, otitis, tracheopharyngitis and coryza. Erdosteine acts through its active metabolites containing free sulfhydryl groups which are able to depolymerize the mucopolysaccharides of the excreatum by breaking the disulfide linkages (thereby lowing its viscosity). The prodrug approach provides unique characteristics to erdosteine by offering stable therapeutic efficacy and prevention of the gastric mucus from lythic phenomena. The agent was also reported to have local antiinflammatory and antielastase properties and enhances penetration of antibiotics into bronchial mucus.

Description

Erdosteine is a mucolytic agent and an antioxidant. It inhibits LPS-induced IκB kinase (IKK) activity, NF-κB-mediated transcription, and production of IL-6 and IL-1β in RAW 264.7 cells. Erdosteine (7.5 mg/kg) prevents depletion of renal catalase and glutathione peroxidase (GPX) and increases in renal malondialdehyde (MDA) and nitric oxide (NO) levels in a rat model of nephrotoxicity induced by cisplatin . It reduces spinal cord lipid peroxidation and destruction of spinal motor neurons in a rabbit model of spinal cord ischemia and reperfusion injury induced by thoracoabdominal aortic clamping. Erdosteine (150 mg/kg) reduces lung weight, MDA and protein carbonyl levels, and macrophage and neutrophil accumulation in a mouse model of acute lung injury induced by oleic acid (Item Nos. 90260 | 24659). Formulations containing erdosteine have been used in the treatment of chronic obstructive pulmonary disease (COPD).

Chemical Properties

Off-White Solid

Originator

Refarmed (Switzerland)

Uses

A mucolytic, developed for the treatment of chronic obstructive bronchitis.

Uses

Erdosteine is a mucolytic. Erdosteine was developed for the treatment of chronic obstructive bronchitis.

Definition

ChEBI: Erdosteine is a N-acyl-amino acid.

brand name

Edirel; Vectrine

Erdosteine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Erdosteine manufacturers

XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD

Product: Erdosteine 84611-23-4
Price: US $55.00/KG
Min. Order: 1KG
Purity: 99.9%
Supply Ability: 500MT/month
Release date: 2021-12-20

Henan Aochuang Chemical Co.,Ltd.

Product: Erdosteine 84611-23-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-17

Zhuozhou Wenxi import and Export Co., Ltd

Product: Erdosteine 84611-23-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

84611-23-4, ErdosteineRelated Search:

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2-[[2-Oxo-2-[(tetrahydro-2-oxo-3-thienyl)aMino]ethyl]thio]acetic Acid

Dithiosteine

Aceticacid, 2-[[2-oxo-2-[(tetrahydro-2-oxo-3-thienyl)aMino]ethyl]thio]-

Erdostiene

2-[[2-oxo-2-[(2-oxo-3-thiolanyl)amino]ethyl]thio]acetic acid

2-[2-OXO-2-(2-OXO-TETRAHYDROTHIOPHEN-3-YLAMINO)ETHYLTHIO]ACETIC ACID

[[2-oxo-2-[(tetrahydro-2-oxo-3-thienyl)amino]ethyl]thio]acetic acid

ERDOSTEINE BP98

[[(Tetrahydro-2-oxothiophene-3-yl)carbamoyl]methylthio]acetic acid

[[2-Oxo-2-[[(2-oxotetrahydrothiophen)-3-yl]amino]ethyl]thio]acetic acid

KW-9144

RV-144

2-[[2-keto-2-[(2-ketotetrahydrothiophen-3-yl)amino]ethyl]thio]acetic acid

2-[2-oxo-2-[(2-oxothiolan-3-yl)amino]ethyl]sulfanylacetic acid

2-[2-oxo-2-[(2-oxothiolan-3-yl)amino]ethyl]sulfanylethanoic acid

((2-oxo-2-((tetrahydro-2-oxo-3-thienyl)amino)ethyl)thio)-aceticaci

acide((2-oxo-3-tetrahydrothienylcarbamoyl)-methylthio)acetique

dl-s-(2-(n-3-(2-oxotetrahydrotheinyl)acetamido))thioglycolicacid

pv144

ERDOSTEINE

Erdosteine&gt

Erdosteine Erdosteine

N-(Tetrahydro-2-oxo-3-thienyl)-3-thiapentanedioic Acid Monoamide

Erdosteine USP/EP/BP

Erdosten

2-[2-oxo-2-[(2-oxothiolan-3-yl)amino]ethyl]sulfanylacetic acid (Erdosteine)

Erdosteine, ≥ 98.0%

84611-23-4

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Sulfur & Selenium Compounds

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