Erdosteine
- Product Name
- Erdosteine
- CAS No.
- 84611-23-4
- Chemical Name
- Erdosteine
- Synonyms
- pv144;RV-144;KW-9144;Erdosten;Erdostiene;ERDOSTEINE;Dithiosteine;Erdosteine>ERDOSTEINE BP98;Erdosteine, ≥ 98.0%
- CBNumber
- CB0230173
- Molecular Formula
- C8H11NO4S2
- Formula Weight
- 249.31
- MOL File
- 84611-23-4.mol
Erdosteine Property
- Melting point:
- 156-160°C
- Boiling point:
- 590.4±50.0 °C(Predicted)
- Density
- 1.48±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- 3.71(at 25℃)
- form
- Solid
- color
- White to Off-White
- λmax
- 236nm(H2O)(lit.)
- Merck
- 14,3647
- InChIKey
- QGFORSXNKQLDNO-UHFFFAOYSA-N
- CAS DataBase Reference
- 84611-23-4(CAS DataBase Reference)
Safety
- RTECS
- AJ1476200
- HS Code
- 2934.99.9001
- Toxicity
- LD50 in mice and rats (g/kg): >10 orally; >3.5 i.v. (Gonella)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H320Causes eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E1026
- Product name
- Erdosteine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $51
- Updated
- 2024/03/01
- Product number
- E1026
- Product name
- Erdosteine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 29177
- Product name
- Erdosteine
- Packaging
- 1g
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 29177
- Product name
- Erdosteine
- Packaging
- 25g
- Price
- $1201
- Updated
- 2024/03/01
- Product number
- 29177
- Product name
- Erdosteine
- Packaging
- 5g
- Price
- $362
- Updated
- 2024/03/01
Erdosteine Chemical Properties,Usage,Production
Description
Erdosteine is a new expectorant introduced in France for the treatment of chronic bronchitis. Erdosteine possesses mucomodulator, mucolytic, mucokinetic and free radical scavenging properties. Its therapeutic efficacy has been demonstrated in patients affected by congestion and viscous mucus in higher and lower respiratory tracts as in acute and chronic bronchitis, sinusitis, otitis, tracheopharyngitis and coryza. Erdosteine acts through its active metabolites containing free sulfhydryl groups which are able to depolymerize the mucopolysaccharides of the excreatum by breaking the disulfide linkages (thereby lowing its viscosity). The prodrug approach provides unique characteristics to erdosteine by offering stable therapeutic efficacy and prevention of the gastric mucus from lythic phenomena. The agent was also reported to have local antiinflammatory and antielastase properties and enhances penetration of antibiotics into bronchial mucus.
Description
Erdosteine is a mucolytic agent and an antioxidant. It inhibits LPS-induced IκB kinase (IKK) activity, NF-κB-mediated transcription, and production of IL-6 and IL-1β in RAW 264.7 cells. Erdosteine (7.5 mg/kg) prevents depletion of renal catalase and glutathione peroxidase (GPX) and increases in renal malondialdehyde (MDA) and nitric oxide (NO) levels in a rat model of nephrotoxicity induced by cisplatin . It reduces spinal cord lipid peroxidation and destruction of spinal motor neurons in a rabbit model of spinal cord ischemia and reperfusion injury induced by thoracoabdominal aortic clamping. Erdosteine (150 mg/kg) reduces lung weight, MDA and protein carbonyl levels, and macrophage and neutrophil accumulation in a mouse model of acute lung injury induced by oleic acid (Item Nos. 90260 | 24659). Formulations containing erdosteine have been used in the treatment of chronic obstructive pulmonary disease (COPD).
Chemical Properties
Off-White Solid
Originator
Refarmed (Switzerland)
Uses
A mucolytic, developed for the treatment of chronic obstructive bronchitis.
Uses
Erdosteine is a mucolytic. Erdosteine was developed for the treatment of chronic obstructive bronchitis.
Definition
ChEBI: Erdosteine is a N-acyl-amino acid.
brand name
Edirel; Vectrine
Erdosteine Preparation Products And Raw materials
Raw materials
Preparation Products
Erdosteine Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23680
- Advantage
- 75
View Lastest Price from Erdosteine manufacturers
- Product
- Erdosteine 84611-23-4
- Price
- US $55.00/KG
- Min. Order
- 1KG
- Purity
- 99.9%
- Supply Ability
- 500MT/month
- Release date
- 2021-12-20
- Product
- Erdosteine 84611-23-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-17
- Product
- Erdosteine 84611-23-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11