N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID
- Product Name
- N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID
- CAS No.
- 288159-40-0
- Chemical Name
- N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID
- Synonyms
- Boc-3-hydroxy-D-Valine;(R)-Boc-?-hydroxy-valine;Boc-3-Methyl-D-threonine;-2-((tert-Butoxycarbonyl);(R)-Boc-beta-hydroxy-valine;N-Boc-3-hydroxy-D-valine, 97%;(R)-Boc-beta, beta-dimethyl-serine;3-Hydroxy-D-valine, N-BOC protected;Boc-(R)-2-amino-3-methylbutanoic acid;(R)-Boc-2-aMino-3-hydroxy-3-Methyl-butyric acid
- CBNumber
- CB0233866
- Molecular Formula
- C10H19NO5
- Formula Weight
- 233.26
- MOL File
- 288159-40-0.mol
N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Property
- Boiling point:
- 391.1±37.0 °C(Predicted)
- Density
- 1.175±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 3.62±0.10(Predicted)
- InChI
- InChI=1S/C10H19NO5/c1-9(2,3)16-8(14)11-6(7(12)13)10(4,5)15/h6,15H,1-5H3,(H,11,14)(H,12,13)/t6-/m0/s1
- InChIKey
- SZVRVSZFEDIMFM-LURJTMIESA-N
- SMILES
- C(O)(=O)[C@@H]([C@@](C)(O)C)NC(OC(C)(C)C)=O
- CAS DataBase Reference
- 288159-40-0
Safety
- HazardClass
- IRRITANT
- HS Code
- 29225090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- FB55458
- Product name
- Boc-(R)-2-amino-3-hydroxy-3-methylbutanoic acid
- Packaging
- 25mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB55458
- Product name
- Boc-(R)-2-amino-3-hydroxy-3-methylbutanoic acid
- Packaging
- 50mg
- Price
- $102.5
- Updated
- 2021/12/16
- Product number
- 28640
- Product name
- Boc-(R)-2-amino-3-hydroxy-3-methylbutanoicacid,98%(Chiralpurity)
- Purity
- 98%(Chiralpurity)
- Packaging
- 100MG
- Price
- $106.4
- Updated
- 2021/12/16
- Product number
- FB55458
- Product name
- Boc-(R)-2-amino-3-hydroxy-3-methylbutanoic acid
- Packaging
- 100mg
- Price
- $164
- Updated
- 2021/12/16
- Product number
- 042074
- Product name
- Boc-(R)-2-amino-3-hydroxy-3-methylbutanoic acid
- Packaging
- 100mg
- Price
- $179
- Updated
- 2021/12/16
N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Chemical Properties,Usage,Production
Chemical Properties
White powder
Synthesis
182958-73-2
288159-40-0
General procedure for the synthesis of (R)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid from tert-butyl (S)-(1,3-dihydroxy-3-methylbutan-2-yl)carbamate: [Step 3] Synthesis of (R)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid: at -35 °C, an aqueous solution of sodium hypochlorite (5.0 mL, containing 0.8 g, 0.64 mmol) and aqueous sodium hypochlorite (10 mL, containing 2.4 g, 27 mmol) were added simultaneously and slowly to an acetonitrile containing Reference Example Compound 36 (2.8 g, 13 mmol), 2,2,6,6-tetramethylpiperidinium 1-yloxy (0.40 g, 2.6 mmol), and a standard neutral phosphate buffer (45 mL) (50 mL) solution. The reaction solution was stirred at -35 °C for 3 h. Acetic acid (1.0 mL) was added. Stirring was continued at -35°C for 3 hours, followed by the addition of water and extraction with ethyl acetate. The organic layer was washed sequentially with water and saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting crude product was dissolved in saturated aqueous sodium bicarbonate solution and washed with ethyl acetate. The aqueous layer was acidified with 3N hydrochloric acid and extracted again with ethyl acetate. The organic layer was washed with water and saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 2.5 g (84% yield) of (R)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid (hereinafter referred to as Reference Example Compound 37).
References
[1] Journal of Organic Chemistry, 2003, vol. 68, # 1, p. 177 - 179
[2] Nature Chemistry, 2010, vol. 2, # 4, p. 280 - 285
[3] Patent: EP2832724, 2015, A1. Location in patent: Paragraph 0188
N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Suppliers
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View Lastest Price from N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID manufacturers
- Product
- N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID 288159-40-0
- Price
- US $2.00/KG
- Min. Order
- 1g
- Purity
- 98%MIN
- Supply Ability
- ASK
- Release date
- 2020-01-09