N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID

Product Name: N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID
CAS No.: 288159-40-0
Chemical Name: N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID
Synonyms: Boc-3-hydroxy-D-Valine;(R)-Boc-?-hydroxy-valine;Boc-3-Methyl-D-threonine;-2-((tert-Butoxycarbonyl);(R)-Boc-beta-hydroxy-valine;N-Boc-3-hydroxy-D-valine, 97%;(R)-Boc-beta, beta-dimethyl-serine;3-Hydroxy-D-valine, N-BOC protected;Boc-(R)-2-amino-3-methylbutanoic acid;(R)-Boc-2-aMino-3-hydroxy-3-Methyl-butyric acid
CBNumber: CB0233866
Molecular Formula: C10H19NO5
Formula Weight: 233.26
MOL File: 288159-40-0.mol

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N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Property

Boiling point:: 391.1±37.0 °C(Predicted)
Density: 1.175±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 3.62±0.10(Predicted)
InChI: InChI=1S/C10H19NO5/c1-9(2,3)16-8(14)11-6(7(12)13)10(4,5)15/h6,15H,1-5H3,(H,11,14)(H,12,13)/t6-/m0/s1
InChIKey: SZVRVSZFEDIMFM-LURJTMIESA-N
SMILES: C(O)(=O)[C@@H]([C@@](C)(O)C)NC(OC(C)(C)C)=O
CAS DataBase Reference: 288159-40-0

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Safety

HazardClass: IRRITANT
HS Code: 29225090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FB55458
Product name: Boc-(R)-2-amino-3-hydroxy-3-methylbutanoic acid
Packaging: 25mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB55458
Product name: Boc-(R)-2-amino-3-hydroxy-3-methylbutanoic acid
Packaging: 50mg
Price: $102.5
Updated: 2021/12/16

Chem-Impex

Product number: 28640
Product name: Boc-(R)-2-amino-3-hydroxy-3-methylbutanoicacid,98%(Chiralpurity)
Purity: 98%(Chiralpurity)
Packaging: 100MG
Price: $106.4
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB55458
Product name: Boc-(R)-2-amino-3-hydroxy-3-methylbutanoic acid
Packaging: 100mg
Price: $164
Updated: 2021/12/16

Matrix Scientific

Product number: 042074
Product name: Boc-(R)-2-amino-3-hydroxy-3-methylbutanoic acid
Packaging: 100mg
Price: $179
Updated: 2021/12/16

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N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Chemical Properties,Usage,Production

Chemical Properties

White powder

Synthesis

182958-73-2

288159-40-0

General procedure for the synthesis of (R)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid from tert-butyl (S)-(1,3-dihydroxy-3-methylbutan-2-yl)carbamate: [Step 3] Synthesis of (R)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid: at -35 °C, an aqueous solution of sodium hypochlorite (5.0 mL, containing 0.8 g, 0.64 mmol) and aqueous sodium hypochlorite (10 mL, containing 2.4 g, 27 mmol) were added simultaneously and slowly to an acetonitrile containing Reference Example Compound 36 (2.8 g, 13 mmol), 2,2,6,6-tetramethylpiperidinium 1-yloxy (0.40 g, 2.6 mmol), and a standard neutral phosphate buffer (45 mL) (50 mL) solution. The reaction solution was stirred at -35 °C for 3 h. Acetic acid (1.0 mL) was added. Stirring was continued at -35°C for 3 hours, followed by the addition of water and extraction with ethyl acetate. The organic layer was washed sequentially with water and saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting crude product was dissolved in saturated aqueous sodium bicarbonate solution and washed with ethyl acetate. The aqueous layer was acidified with 3N hydrochloric acid and extracted again with ethyl acetate. The organic layer was washed with water and saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 2.5 g (84% yield) of (R)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid (hereinafter referred to as Reference Example Compound 37).

References

[1] Journal of Organic Chemistry, 2003, vol. 68, # 1, p. 177 - 179
[2] Nature Chemistry, 2010, vol. 2, # 4, p. 280 - 285
[3] Patent: EP2832724, 2015, A1. Location in patent: Paragraph 0188

N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Suppliers

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View Lastest Price from N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID manufacturers

Career Henan Chemical Co

Product: N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID 288159-40-0
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%MIN
Supply Ability: ASK
Release date: 2020-01-09

288159-40-0, N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACIDRelated Search:

BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID,N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID allo-DL-Threonine N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID BOC-D-THR-OH D-beta-Hydroxyvaline (R)-2-Amino-3-hydroxy-3-methylbutanoic acid BOC-(RS)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID D(-)-allo-Threonine Boc-D-Serine

BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID

(R)-Boc-2-aMino-3-hydroxy-3-Methyl-butyric acid

(R)-Boc-beta-hydroxy-valine

N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID

Boc-(R)-2-amino-3-methylbutanoic acid

(R)-Boc-beta, beta-dimethyl-serine

N-Boc-3-hydroxy-D-valine, 97%

3-Hydroxy-D-valine, N-BOC protected

N-(tert-Butoxycarbonyl)-3-hydroxy-D-valine, (2R)-2-[(tert-Butoxycarbonyl)amino]-3-hydroxy-3-methylbutanoic acid

-2-((tert-Butoxycarbonyl)

(R)-Boc-?-hydroxy-valine

Boc-(R)-2-amino-3-hydroxy-3-methylbutanoic acid≥ 99% (HPLC)

(2R)-3-hydroxy-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid

D-Threonine, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-

(2R)-3-hydroxy-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoicaci

N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID USP/EP/BP

Boc-3-hydroxy-D-Valine

(R)-2-(Boc-amino)-3-hydroxy-3-methylbutanoic Acid

Boc-3-Methyl-D-threonine

288159-40-0

unnatural amino acids