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ChemicalBook > CAS DataBase List > 2,6-Diaminopyridine

2,6-Diaminopyridine

Uses
Product Name
2,6-Diaminopyridine
CAS No.
141-86-6
Chemical Name
2,6-Diaminopyridine
Synonyms
2,6-DAP;Diaminopyridine;6-DiaMinopyridine;2,6-Pyridinediamine;pyridine-2,6-diyldiamine;26BD;NSC 403346;RODOL 26PYR;2.6-DiaMinopyr;2,6-Diaminopyridine
CBNumber
CB0236195
Molecular Formula
C5H7N3
Formula Weight
109.13
MOL File
141-86-6.mol
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2,6-Diaminopyridine Property

Melting point:
117-122 °C (lit.)
Boiling point:
285 °C (lit.)
Density 
1.7110 (rough estimate)
refractive index 
1.5340 (estimate)
Flash point:
155°C
storage temp. 
Store below +30°C.
solubility 
180g/l
pka
6.13±0.24(Predicted)
form 
Flakes or Crystalline Powder
color 
Beige to dark brown-gray
PH
>7 (H2O)
Water Solubility 
9.9 g/100 mL (20 ºC)
BRN 
108513
InChIKey
VHNQIURBCCNWDN-UHFFFAOYSA-N
LogP
0.550 (est)
CAS DataBase Reference
141-86-6(CAS DataBase Reference)
NIST Chemistry Reference
2,6-Pyridinediamine(141-86-6)
EPA Substance Registry System
2,6-Pyridinediamine (141-86-6)
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Safety

Hazard Codes 
Xn,T,Xi
Risk Statements 
22-36/37/38-25-20/21
Safety Statements 
26-45-37/39-28A-36
RIDADR 
2811
WGK Germany 
3
RTECS 
US7570000
F 
9
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29333999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D24404
Product name
2,6-Diaminopyridine
Purity
98%
Packaging
25g
Price
$51.5
Updated
2024/03/01
Sigma-Aldrich
Product number
D24404
Product name
2,6-Diaminopyridine
Purity
98%
Packaging
100g
Price
$129
Updated
2024/03/01
Sigma-Aldrich
Product number
8.03575
Product name
2,6-Diaminopyridine
Purity
for synthesis
Packaging
100g
Price
$77.2
Updated
2024/03/01
TCI Chemical
Product number
D1154
Product name
2,6-Diaminopyridine
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$30
Updated
2024/03/01
Alfa Aesar
Product number
A12295
Product name
2,6-Diaminopyridine, 98%
Packaging
100g
Price
$41.65
Updated
2024/03/01
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2,6-Diaminopyridine Chemical Properties,Usage,Production

Uses

2,6-Diaminopyridine(141-86-6) can be used to synthesize pentamidine derivatives which show antitumor activities and DNA binding activities. It can also be used to synthesize N-monocarbamoyl derivatives of symmetrical diamines with antiviral activity. Its derivatives can be used as models of molecular sensor for nucleic acid base detection.

Description

2,6-Diaminopyridine is an important organic reagent with a wide range of uses. It can be used for fluorescence detection, 2,6-Diaminopyridine fluorescence method for the determination of certain aromatic primary amines. It can also be used to prepare 2,6-Diaminopyridine imprinted core-shell nanoparticles. A new method for the detection of diaminopyridine derivatives using molecularly imprinted electrochemical sensors has been established, which has been applied to the detection of 2,6-Diaminopyridine in hair dyes with good sensitivity and selectivity.

Chemical Properties

Off-white crystal powder/granuale

Uses

2,6-Diaminopyridine, used as a pharmaceutical intermediate and a hair dye coupler in oxidation/permanent formulations.

Preparation

In a 600 mL autoclave equipped with a gas entrapment stirrer, a solution of 5 g CuI in 120 g aqueous ammonia (30% NH3 by weight) was added and mixed with 77 g ammonium acetate and 60 g of 2, 6-dichloropyridine. After purging with nitrogen, 24 g of liquid ammonia was added resulting in a pressure of about 150 psi (1.03 MPa). Subsequently, the reaction mixture was heated to 150°C for 8 h under stirring. Throughout the reaction, the pressure decreased from an initial pressure of 680 psi (4.69 MPa) to 450 psi (3.10 MPa). The reaction mixture was allowed to cool to room temperature, and the pressure was brought back to atmospheric pressure. Finally, 2,6-Diaminopyridine was obtained after purification.

Safety Profile

Poison by intravenous and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Toxicity evaluation

2,6-Diaminopyridine was not mutagenic in Salmonella typhimurium strain TA98 in the presence or absence of nonharman at 200 μg/plate. The mutagenicity of this compound was not enhanced by rodent liver S-9 (Sugimura et al., 1982).
In another study, it was not mutagenic in S. typhimurium strain TA98 without rodent liver S-9. However, it was mutagenic in the presence of rodent liver S-9 (Takahashi & Ono, 1993). 
This compound was not mutagenic in S. typhimurium strains TA98, TA100, and TA1535 in the presence or absence of rodent liver S-9 (JETOC, 1997; Takahashi & Ono, 1993)
It was mutagenic in S. typhimurium strain TA1537 in the presence or absence of rodent liver S-9 (JETOC, 1997).
2,6-Diaminopyridine was not mutagenic in Escherichia coli strain WP2 uvrA in the presence or absence of rodent liver S-9 (JETOC, 1997).

2,6-Diaminopyridine Preparation Products And Raw materials

Raw materials

2-Aminopyridine

Preparation Products

7-FLUORO-[1,8]NAPHTHYRIDIN-2-OL 2,6-DIAMINO-3-BROMOPYRIDINE Minoxidil 3-Bromo-2,6-diaminopyridine ,95%
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2,6-Diaminopyridine Suppliers

Americas 1 Belgium 3 Canada 4 China 420 Czech Republic 1 Europe 4 France 1 Germany 5 India 59 Japan 5 Jordan 1 Slovakia 1 South Korea 2 Switzerland 3 Ukraine 1 United Kingdom 14 United States 44 Global 569
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View Lastest Price from 2,6-Diaminopyridine manufacturers

Asia Chem I and E (Jiangsu) Co Ltd
Product
2,6-Diaminopyridine 141-86-6
Price
US $68.40/Kg/Drum
Min. Order
5Kg/Drum
Purity
99.00%HPLC
Supply Ability
6tons/month
Release date
2021-11-09
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
2, 6-Diaminopyridine 141-86-6
Price
US $180.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-06-06
WUHAN FORTUNA CHEMICAL CO., LTD
Product
2,6-Diaminopyridine 141-86-6
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-10

141-86-6, 2,6-DiaminopyridineRelated Search:

2-Aminopyridine 3-Aminopyridine DIMETHYLAMINOPYRIDINE, POLYMER-BOUND 4-Aminopyridine 4-Dimethylaminopyridine 3-(PHENYLAZO)-2,6-PYRIDINEDIAMINE 2,6-DIAMINO-3-NITROSOPYRIDINE Phenazopyridine hydrochloride 2,6-DIACETYLAMINOPYRIDINE 2,5-DIAMINOPYRIDINE 2,3-DIAMINOPYRIDINE,2,3-Diaminopyridine,98%,2,3-Diaminopyridine99% 2,6-DIAMINO-4-METHYL PYRIDINE Enoxacin 2,4-DIAMINOPYRIDINE 3,4-DIAMINOPYRIDINE,DIAMINOPYRIDINE(3,4-),4,5-diaminopyridin 2,3-Diamino-6-methoxypyridine 4-Chloro-2,6-diaminopyridine PYRIDINE-2,3,6-TRIAMINE

  • 2,6-diamino-pyridin
  • Diaminopyridine
  • Pyridine, 2,6-diamino-
  • pyridine-2,6-diyldiamine
  • 2 6-DIAMINOPYRIDINE 99+% &
  • 2,6-Diaminopyridine,>98%
  • D**2,6-Diaminopyridine
  • 2,6-DAP
  • 2,6-Diaminopyridine
  • 2,6-Pyridinediamine
  • RODOL 26PYR
  • 6-Amino-2(1H)-pyridinimine
  • 2.6-Diaminopyridine 10g [141-86-6]
  • 6-DiaMinopyridine
  • 2,6-DiaMinopyridine, 98% 100GR
  • NSC 403346
  • Pyridine, 2,6-diaMino- (6CI,8CI)
  • 2, 6-2 aMinopyridine
  • 2.6-DiaMinopyr
  • 2,6-Diaminopyridine Vetec(TM) reagent grade, 98%
  • 2,6-DIAMINOPYRIDINE FOR SYNTHESIS
  • 2,6-DAP 2,6-DiaMinopyridine
  • 2,6-Diaminopyridine ( CAS : 141-86-6)
  • 2,6-Diaminopyridine@100 μg/mL in Methanol
  • Diaminopyridine Diaminopyridine
  • 2,6-Diaminopyridine, 98%, for synthesis
  • 2,6-Diaminopyridine &gt
  • 2,6-diamino-pyridine(2.6BD)
  • 26BD
  • 2,6-Diaminopyridine ISO 9001：2015 REACH
  • 2,6-Diaminopyridine?New
  • Dopexamine Impurity 16
  • 141-86-6
  • C5H9N3O4S
  • AMINE
  • C5
  • Building Blocks
  • Heterocyclic Building Blocks
  • Pyridines
  • Pyridine
  • C5
  • Heterocyclic Building Blocks
  • Pyridines
  • Pyridines derivates
  • compounds of pyridine
  • Intermediates