5-Iodo-3-methyl-2-pyridinamine
- Product Name
- 5-Iodo-3-methyl-2-pyridinamine
- CAS No.
- 166266-19-9
- Chemical Name
- 5-Iodo-3-methyl-2-pyridinamine
- Synonyms
- AKOS BB-8252;ASISCHEM X20904;ART-CHEM-BB B025286;2-Amino-5-iodo-3-methyL;2-AMINO-5-IODO-3-PICOLINE;5-IODO-3-METHYLPYRIDIN-2-AMINE;5-IODO-3-METHYL-2-PYRIDINAMINE;2-amino-3-methyl-5-iodopyridine;2-AMINO-5-IODO-3-METHYLPYRIDINE;2-Amino-3-methyl-5-iodipyridine
- CBNumber
- CB0237884
- Molecular Formula
- C6H7IN2
- Formula Weight
- 234.04
- MOL File
- 166266-19-9.mol
5-Iodo-3-methyl-2-pyridinamine Property
- Melting point:
- 110.2-110.5°C
- Boiling point:
- 303.4±42.0 °C(Predicted)
- Density
- 1.898±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- soluble in Methanol
- form
- solid
- pka
- 5.22±0.49(Predicted)
- Appearance
- Light yellow to yellow Solid
- Sensitive
- Light Sensitive
- λmax
- 296nm(lit.)
- InChIKey
- WTHKBDPHSGITFJ-UHFFFAOYSA-N
- CAS DataBase Reference
- 166266-19-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- ADE000317
- Product name
- 5-Iodo-3-methyl-pyridin-2-ylamine
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $179
- Updated
- 2025/07/31
- Product number
- A2683
- Product name
- 2-Amino-5-iodo-3-methylpyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $96
- Updated
- 2025/07/31
- Product number
- A2683
- Product name
- 2-Amino-5-iodo-3-methylpyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $288
- Updated
- 2025/07/31
- Product number
- I737193
- Product name
- 5-Iodo-3-methyl-2-pyridinamine
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FA08612
- Product name
- 2-Amino-5-iodo-3-methylpyridine
- Packaging
- 5G
- Price
- $236.3
- Updated
- 2021/12/16
5-Iodo-3-methyl-2-pyridinamine Chemical Properties,Usage,Production
Synthesis
3430-21-5
166266-19-9
General procedure for the synthesis of 2-amino-3-methyl-5-iodopyridine from 2-amino-3-methyl-5-bromopyridine: 5-bromo-3-methylpyridin-2-amine (2 g, 10.6 mmol), sodium iodide (3.2 g, 21.4 mmol), and copper iodide (0.190 g, 1.06 mmol) were added to dioxane (10 mL), the solution was degassed and tetramethylethane-1,2-diamine (0.803 mL, 1.06 mmol) was added. The mixture was heated at 110 °C overnight. After completion of the reaction, it was cooled to room temperature, water was added and the crude product was extracted with ethyl acetate. The residue was purified by column chromatography to afford 5-iodo-3-methylpyridin-2-amine as a beige solid (2.3 g, 93% yield). Similar to the procedure described in Example 40, 6-fluoro-7-(methylamino)-2,3-dihydrobenzo[e][1,3]oxazin-4-one (0.100 g, 0.51 mmol) was reacted with 5- iodo-3-methylpyridin-2-amine (0.119 g, 0.53 mmol) to give, after reversed-phase HPLC purification, the pure 3- (6-amino pyridin-3-yl) -6-fluoro-7-(methylamino)-2,3-dihydrobenzo[e][1,3]oxazin-4-one (0.020 g, 13% yield). ES-MS (M + H)+ = 303. Following the method of sulfonylurea formation described in Example 5, 3-(6-amino-5-methylpyridin-3-yl)-6-fluoro-7-(methylamino)-2,3-dihydrobenzo[e] [1,3]oxazin-4-one (0.010 g, 0.034 mmol) was coupled with ethyl (5-chlorothiophene-2-sulfonyl)-carbamate (0.048 g, 0.166 mmol) to afford 1-(5-chlorothiophene-2-ylsulfonyl)-3-(5-(6-fluoro-7-(methylamino)-4-oxo-2H-benzo[e][1,3]oxazine -3(4H)-yl)-3-methylpyridin-2-yl)urea (0.016 g, 85% yield).RP-HPLC retention time: 2.7 min; ES-MS (M + H)+ = 526.0; 1H-NMR (DMSO-d6) δ (ppm): 2.2 (s, 3H), 2.8 (s, 3H), 5.6 (s, 2H), 6.2 ( d, 1H), 6.8 (bs, 1H), 7.2 (s, 1H), 7.4 (d, 1H), 7.6 (s, 1H), 7.8 (d, 1H), 8.2 (d, 1H), 9.6 (bs, 1H).
References
[1] Patent: US2006/69093, 2006, A1. Location in patent: Page/Page column 23
5-Iodo-3-methyl-2-pyridinamine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Iodo-3-methyl-2-pyridinamine manufacturers
- Product
- 5-Iodo-3-methyl-2-pyridinamine 166266-19-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-30
- Product
- 5-Iodo-3-methyl-2-pyridinamine 166266-19-9
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 5-Iodo-3-methyl-2-pyridinamine 166266-19-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-01