ChemicalBook > CAS DataBase List > 2-(Chloromethyl)thiophene

2-(Chloromethyl)thiophene

Product Name
2-(Chloromethyl)thiophene
CAS No.
765-50-4
Chemical Name
2-(Chloromethyl)thiophene
Synonyms
Thenyl chloride;2-(chloromethyl)thiophene;THIOPHENE, 2-(CHLOROMETHYL)-;2-(Chloromethyl)thiophene###765-50-4;2-(Chloromethyl)thiophene ISO 9001：2015 REACH;2-(Chloromethyl)thiophene, 33% w/w solution in toluene
CBNumber
CB0238735
Molecular Formula
C5H5ClS
Formula Weight
132.61
MOL File
765-50-4.mol
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2-(Chloromethyl)thiophene Property

Boiling point:
80-81 °C(Press: 18 Torr)
Density 
1.243±0.06 g/cm3(Predicted)
storage temp. 
Amber Vial, -20°C Freezer
solubility 
Acetonitrile, Chloroform
form 
Oil
color 
Colourless
CAS DataBase Reference
765-50-4(CAS DataBase Reference)
NIST Chemistry Reference
Thiophene, 2-(chloromethyl)-(765-50-4)
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Safety

RIDADR 
1993
HazardClass 
3
PackingGroup 
Ⅲ
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B419458
Product name
2-(Chloromethyl)thiophene
Packaging
500mg
Price
$195
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0011564
Product name
2-CHLOROMETHYLTHIOPHENE
Purity
95.00%
Packaging
1G
Price
$166.95
Updated
2021/12/16
Matrix Scientific
Product number
189789
Product name
2-(Chloromethyl)thiophene
Packaging
5g
Price
$196
Updated
2021/12/16
Matrix Scientific
Product number
189789
Product name
2-(Chloromethyl)thiophene
Packaging
10g
Price
$323
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0011564
Product name
2-CHLOROMETHYLTHIOPHENE
Purity
95.00%
Packaging
5G
Price
$514.5
Updated
2021/12/16
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2-(Chloromethyl)thiophene Chemical Properties,Usage,Production

Chemical Properties

Colorless Liquid

Synthesis

636-72-6

765-50-4

The general procedure for the synthesis of 2-chloromethylthiophene from 2-thiophenemethanol was as follows: 2-thiophenemethanol (5,58 g, 509 mmol) and pyridine (60 g, 763 mmol) were dissolved in 600 mL of anhydrous dichloromethane at 0 °C, and thionyl chloride was added slowly and dropwise. The reaction mixture was stirred at 0°C for 1 hour, then brought to room temperature and continued to stir overnight. Upon completion of the reaction, the reaction was quenched by the addition of 500 mL of water. The organic layer was separated and the aqueous layer was extracted twice with 300 mL of dichloromethane. The organic layers were combined and washed sequentially with 600 mL of 5% aqueous sodium bicarbonate and 300 mL of brine. The organic layer was dried with anhydrous sodium sulfate and concentrated to give 40 g of 2-chloromethylthiophene (6) as an oil in 60% yield.

References

[1] European Journal of Medicinal Chemistry, 2001, vol. 36, # 11-12, p. 873 - 886
[2] European Journal of Pharmaceutical Sciences, 2002, vol. 16, # 1-2, p. 15 - 28
[3] European Journal of Organic Chemistry, 2014, vol. 2014, # 11, p. 2365 - 2370
[4] Tetrahedron, 1998, vol. 54, # 25, p. 6999 - 7012
[5] Synthetic Communications, 2005, vol. 35, # 15, p. 2079 - 2083

2-(Chloromethyl)thiophene Preparation Products And Raw materials

Raw materials

Desiccant

Preparation Products

2-[2-(2-thienyl)ethyl]benzoic acid 4-Oxo-9,10-dihydro-4H-benzo(4,5)-cyclohepta-(1,2b)thiophene 2-(b-(2-Thienyl)vinyl)benzoicacid THIOPHEN-2-YLMETHYL-PHOSPHONIC ACID DIETHYL ESTER
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View Lastest Price from 2-(Chloromethyl)thiophene manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-(Chloromethyl)thiophene 765-50-4
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-04-26
Shaanxi Dideu Medichem Co. Ltd
Product
2-(Chloromethyl)thiophene 765-50-4
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2024-07-14
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-(Chloromethyl)thiophene 765-50-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

765-50-4, 2-(Chloromethyl)thiopheneRelated Search:

2-Methylbenzyl chloride Thiophene Chlorodimethylphenylsilane tert-Butyldimethylsilyl chloride 2-Chlorothiophene Chloromethyl isopropyl carbonate Chloromethane 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE 3-BROMOTHIOPHENE-2-CARBONYL CHLORIDE 3-CHLORO-6-METHOXYBENZO[B]THIOPHENE-2-CARBONYL CHLORIDE 2-CHLORO-5-(CHLOROMETHYL)THIOPHENE 3-METHYLTHIOPHENE-2-CARBONYL CHLORIDE 3-CHLOROBENZO[B]THIOPHENE-2-CARBONYL CHLORIDE 2-Chloro-3-chloromethylthiophene BENZO[B]THIOPHENE-2-CARBONYL CHLORIDE 4-[(4-CHLOROPHENYL)SULFONYL]-3-METHYLTHIOPHENE-2-CARBONYL CHLORIDE 3-CHLORO-4-(ISOPROPYLSULFONYL)THIOPHENE-2-CARBONYL CHLORIDE Chloromethyl methyl ether

  • THIOPHENE, 2-(CHLOROMETHYL)-
  • 2-(chloromethyl)thiophene
  • 2-(Chloromethyl)thiophene###765-50-4
  • 2-(Chloromethyl)thiophene, 33% w/w solution in toluene
  • 2-(Chloromethyl)thiophene ISO 9001：2015 REACH
  • Thenyl chloride
  • 765-50-4
  • C5H4SCl
  • CH5ClS
  • Sulfur
  • API Intermediate