ETHYL 4-METHOXYBENZOYLACETATE

Product Name: ETHYL 4-METHOXYBENZOYLACETATE
CAS No.: 2881-83-6
Chemical Name: ETHYL 4-METHOXYBENZOYLACETATE
Synonyms: MOBEE;AKOS 228-23;BUTTPARK 18\10-44;ETHYL P-ANISOYLACETATE;ETHYL 4-METHOXYBENZOYLACETATE;Ethyl p-methoxybenzoyl acetate;Ethyl4-Methoxybenzoylacetate>P-ANISOYLACETIC ACID ETHYL ESTER;Acetic acid, p-anisoyl-, ethyl ester;4-METHOXYBENZOYLACETIC ACID ETHYL ESTER
CBNumber: CB0240202
Molecular Formula: C12H14O4
Formula Weight: 222.24
MOL File: 2881-83-6.mol

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ETHYL 4-METHOXYBENZOYLACETATE Property

Boiling point:: 154 °C1 hPa(lit.)
Density: 1.160 g/mL at 20 °C(lit.)
refractive index: 1.5410 to 1.5460
Flash point:: 115°C
storage temp.: Sealed in dry,Room Temperature
solubility: H2O: soluble
form: clear liquid
pka: 10.34±0.25(Predicted)
color: Light yellow to Yellow to Orange
InChI: InChI=1S/C12H14O4/c1-3-16-12(14)8-11(13)9-4-6-10(15-2)7-5-9/h4-7H,3,8H2,1-2H3
InChIKey: KRAHENMBSVAAHD-UHFFFAOYSA-N
SMILES: C1(=CC=C(OC)C=C1)C(=O)CC(=O)OCC
CAS DataBase Reference: 2881-83-6(CAS DataBase Reference)
EPA Substance Registry System: Benzenepropanoic acid, 4-methoxy-.beta.-oxo-, ethyl ester (2881-83-6)

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
WGK Germany: 3
HS Code: 2918.99.4700

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M1380
Product name: Ethyl (4-Methoxybenzoyl)acetate
Packaging: 5G
Price: $30
Updated: 2025/07/31

TCI Chemical

Product number: M1380
Product name: Ethyl (4-Methoxybenzoyl)acetate
Purity: >97.0%(GC)
Packaging: 25g
Price: $137
Updated: 2025/07/31

AK Scientific

Product number: J55409
Product name: Ethyl (4-Methoxybenzoyl)acetate
Packaging: 500g
Price: $1280
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0014345
Product name: ETHYL 4-METHOXYBENZOYLACETATE
Purity: 95.00%
Packaging: 250G
Price: $4361.9
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0014345
Product name: ETHYL 4-METHOXYBENZOYLACETATE
Purity: 95.00%
Packaging: 25KG
Price: $9141.83
Updated: 2021/12/16

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ETHYL 4-METHOXYBENZOYLACETATE Chemical Properties,Usage,Production

Synthesis Reference(s)

Tetrahedron Letters, 14, p. 4207, 1973 DOI: 10.1016/S0040-4039(01)87150-1
Synthesis, p. 290, 1993 DOI: 10.1055/s-1993-25849

Synthesis

100-06-1

105-58-8

2881-83-6

To a stirred mixture of sodium hydride (3 mol eq.) and diethyl carbonate (4 mol eq.) in 50 mL of tetrahydrofuran (THF) washed with hexane (3 x 15 mL), p-methoxyacetophenone (1 mol eq.) was slowly added dropwise for a controlled period of 30 min or more. The reaction mixture was heated and refluxed for 3-4 h until the color of the reaction solution changed to dark brown and the reaction progress was monitored by thin layer chromatography (TLC, unfolding agent 10% ethyl acetate/hexane). Upon completion of the reaction, the mixture was cooled to room temperature and acidified with 5 mL of glacial acetic acid, followed by the addition of 100 mL of ice-cold dilute hydrochloric acid solution. The aqueous phase was extracted with ethyl acetate (3 x 75 mL) and the organic phases were combined and washed sequentially with saturated sodium bicarbonate solution, saturated saline and deionized water. The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to give ethyl 3-(4-methoxyphenyl)-3-oxopropanoate as a viscous substance in good yield. The structure of the product was confirmed by 1H NMR and 13C NMR spectroscopy and the data were in agreement with literature reports.

References

[1] European Journal of Organic Chemistry, 2017, vol. 2017, # 31, p. 4543 - 4547
[2] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 14, p. 4237 - 4244
[3] Angewandte Chemie - International Edition, 2012, vol. 51, # 34, p. 8661 - 8664
[4] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 17, p. 5064 - 5075
[5] European Journal of Organic Chemistry, 2012, # 35, p. 6976 - 6985

ETHYL 4-METHOXYBENZOYLACETATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 4-METHOXYBENZOYLACETATE Suppliers

Americas 1 Belgium 1 Canada 1 China 133 Europe 1 Germany 4 India 4 Japan 4 Switzerland 3 Ukraine 1 United Kingdom 6 United States 25 Global 184

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View Lastest Price from ETHYL 4-METHOXYBENZOYLACETATE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: ETHYL 4-METHOXYBENZOYLACETATE 2881-83-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: Ethyl (4-Methoxybenzoyl)acetate 2881-83-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: ETHYL 4-METHOXYBENZOYLACETATE 2881-83-6
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-09

2881-83-6, ETHYL 4-METHOXYBENZOYLACETATERelated Search:

Ethyl 3,4,5-trimethoxybenzoylacetate ETHYL 4-METHOXYBENZOYLACETATE Quincarbate PHENOXYACETIC ACID Ethyl benzoylacetate 3-BENZO[1,3]DIOXOL-5-YL-3-OXO-PROPIONIC ACID ETHYL ESTER 3-(2-HYDROXY-4-METHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER 3-OXO-3-(4-PHENOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER 3-(4-METHOXY-PHENYL)-2,3-DIOXO-PROPIONIC ACID TERT-BUTYL ESTER BETA-OXO-4-(PHENYLMETHOXY)-BENZENEPROPANOIC ACID ETHYL ESTER 3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER 3-(2,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER 2-(4-NITRO-PHENYL)-3-OXO-3-(2,4,5-TRIMETHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER AURORA 17731 diethyl (3,4,5-trimethoxybenzoyl)malonate ETHYL 4-OXO-7-(BENZYLOXY)HYDROQUINOLINE-3-CARBOXYLATE AURORA 17732 3-(2,4-DIMETHOXY-PHENYL)-2-(4-NITRO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER

3-keto-3-(4-methoxyphenyl)propionic acid ethyl ester

p-Anisoylacetic Acid Ethyl Ester Ethyl p-Anisoylacetate 4-Methoxybenzoylacetic Acid Ethyl Ester

3-(4-Methoxy-phenyl)-3-oxo-propionic acid ethyl ester

2-(p-Methoxybenzoyl)acetic acid ethyl ester

3-(4-methoxyphenyl)-3-oxopropanoic acid ethyl ester

Acetic acid, p-anisoyl-, ethyl ester

P-ANISOYLACETIC ACID ETHYL ESTER

MOBEE

4-methoxy-beta-oxo-benzenepropanoicaciethylester

Benzenepropanoic acid, 4-methoxy-β-oxo-, ethyl ester

2-[(4-methoxyphenyl)-oxomethyl]butanoate

Benzenepropanoicacid,4-methoxy-.beta.-oxo-,ethylester

AKOS 228-23

4-METHOXYBENZOYLACETIC ACID ETHYL ESTER

ETHYL P-ANISOYLACETATE

ETHYL 4-METHOXYBENZOYLACETATE

ETHYL 3-(4-METHOXY-PHENYL)-3-OXOPROPANOATE

ETHYL 3(-4METHOXYPHENYL)-3-OXOPROPIONATE

BUTTPARK 18\10-44

Ethyl p-methoxybenzoyl acetate

p-Methoxybenzoyl acetic acid, ethyl ester

Ethyl4-Methoxybenzoylacetate&gt

Benzenepropanoic acid, 4-methoxy-beta-oxo-, ethyL

Ethyl 3-(4-methoxyphenyl)-3-oxopropanoate (or) ethyl (4-methoxybenzoyl)acetate

2881-83-6

Organic Building Blocks

Esters

Building Blocks

C12 to C63

Carbonyl Compounds

Pharmaceutical Intermediates

Benzoic acid