4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE

Product Name: 4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE
CAS No.: 101574-65-6
Chemical Name: 4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE
Synonyms: CS-1084;GSK 4716, ERRbetagamma agonist;4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide;4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide;(E)-4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide;4-hydroxy-N'-(4-isopropylphenyl‐ methylidene)-benzohydrazide;4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE;2-[[4-(1-Methylethyl)phenyl]methylene]hydrazide 4-hydroxybenzoic acid;4-Hydroxybenzoic acid 2-[[4-(1-methylethyl)phenyl]methylene]hydrazide;Benzoic acid, 4-hydroxy-, 2-[[4-(1-methylethyl)phenyl]methylene]hydrazide
CBNumber: CB02446303
Molecular Formula: C17H18N2O2
Formula Weight: 282.34
MOL File: 101574-65-6.mol

More

Less

4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE Property

Density: 1.12
storage temp.: Inert atmosphere,2-8°C
solubility: DMSO: >10mg/mL
form: powder
pka: 8.48±0.15(Predicted)
color: white to off-white

More

Less

Safety

Hazard Codes: Xi,N
Risk Statements: 43-50/53
Safety Statements: 36/37-60-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
HazardClass: 9

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G6173
Product name: GSK 4716
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $108
Updated: 2024/03/01

Sigma-Aldrich

Product number: G6173
Product name: GSK 4716
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $426
Updated: 2024/03/01

Alfa Aesar

Product number: J65166
Product name: GSK 4716
Packaging: 10mg
Price: $70
Updated: 2021/12/16

Alfa Aesar

Product number: J65166
Product name: GSK 4716
Packaging: 50mg
Price: $248
Updated: 2021/12/16

Cayman Chemical

Product number: 17233
Product name: GSK 4716
Purity: ≥98%
Packaging: 5mg
Price: $40
Updated: 2024/03/01

More

Less

4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE Chemical Properties,Usage,Production

Description

The estrogen-related receptors (ERRs) are orphan nuclear receptors with homology to the estrogen receptor family and are expressed in tissues with high metabolic demand. Binding of peroxisome proliferator-activated receptor γ-coactivator 1α (PGC-1α) to this class of receptors is known to potentiate ERR activity. GSK4716 is an ERRβ/γ agonist (IC₅₀ = 2 μM) that can activate the receptor with similar potency as the protein ligand, PGC-1α. It is more than 50-fold selective for binding to ERRβ/γ compared with the estrogen receptors. This compound has been used to demonstrate the contribution of ERR receptor activity to the regulation of mitochondrial activity in skeletal muscle during exercise.

Uses

The estrogen-related receptors (ERRs) are orphan nuclear receptors with homology to the estrogen receptor family and are expressed in tissues with high metabolic demand. Binding of peroxisome proliferator-activated receptor γ-coactivator 1α (PGC-1α) to this class of receptors is known to potentiate ERR activity. GSK4716 is an ERRβ/γ agonist (IC50 = 2 μM) that can activate the receptor with similar potency as the protein ligand, PGC-1α. It is more than 50-fold selective for binding to ERRβ/γ compared with the estrogen receptors. This compound has been used to demonstrate the contribution of ERR receptor activity to the regulation of mitochondrial activity in skeletal muscle during exercise.[Cayman Chemical]

Uses

Selective agonist at estrogen-related receptors ERR and ERR

Definition

ChEBI: GSK 4716 is a monoterpenoid.

Biological Activity

Selective agonist at estrogen-related receptors ERR β and ERR γ . Displays selectivity over ERR α and the classical estrogen receptors.

storage

Store at +4°C

4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE Suppliers

China 53 India 2 Russia 1 Switzerland 1 United Kingdom 4 United States 14 USA 1 Global 76

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

Alfa Chemistry

Tel
Fax: 1-516-927-0118
Email: Info@alfa-chemistry.com
Country: United States
ProdList: 24072
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

Santa Cruz Biotechnology, Inc.

Tel: --
Fax: --
Email: scbt@scbt.com
Country: United States
ProdList: 3597
Advantage: 60

Abcam

Tel: --
Fax: --
Email: us.orders@abcam.com
Country: United States
ProdList: 6000
Advantage: 50

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

More

Less

View Lastest Price from 4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE manufacturers

Career Henan Chemical Co

Product: 4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE 101574-65-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1lg; 2kg; 5kg; 10kg; 100kg
Release date: 2019-08-31

101574-65-6, 4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDERelated Search:

Entospletinib (GS-9973) GS9620 GSK2643943A GS967 GSK J1 GSK-114 GSK-626616 3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester Selonsertib Presatovir 4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE

(E)-4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide

4-Hydroxybenzoic acid 2-[[4-(1-methylethyl)phenyl]methylene]hydrazide

4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE

2-[[4-(1-Methylethyl)phenyl]methylene]hydrazide 4-hydroxybenzoic acid

4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide

CS-1084

Benzoic acid, 4-hydroxy-, 2-[[4-(1-methylethyl)phenyl]methylene]hydrazide

4-hydroxy-N'-(4-isopropylphenyl‐ methylidene)-benzohydrazide

4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide

GSK 4716, ERRbetagamma agonist

101574-65-6

Selective agonist at estrogen-related receptors ERRβ and ERRγ.