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1-TRITYL-1H-1,2,4-TRIAZOLE

Product Name
1-TRITYL-1H-1,2,4-TRIAZOLE
CAS No.
31250-99-4
Chemical Name
1-TRITYL-1H-1,2,4-TRIAZOLE
Synonyms
1-trityl-1,2,4-triazole;1-TRITYL-1H-1,2,4-TRIAZOLE;1-triphenylmethyl-1,2,4-triazole;1-(triphenylMethyl)-1H-1,2,4-Triazole;1H-1,2,4-Triazole, 1-(triphenylmethyl)-
CBNumber
CB02446550
Molecular Formula
C21H17N3
Formula Weight
311.38
MOL File
31250-99-4.mol
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1-TRITYL-1H-1,2,4-TRIAZOLE Property

storage temp. 
Sealed in dry,Room Temperature
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
CHM1041755
Product name
1-TRITYL-1H-1,2,4-TRIAZOLE
Purity
95.00%
Packaging
5MG
Price
$496.72
Updated
2021/12/16
Chemenu
Product number
CM124885
Product name
1-trityl-1H-1,2,4-triazole
Purity
95%
Packaging
1g
Price
$206
Updated
2021/12/16
Alichem
Product number
31250994
Product name
1-Trityl-1H-1,2,4-triazole
Packaging
1g
Price
$215.6
Updated
2021/12/16
Chemenu
Product number
CM124885
Product name
1-trityl-1H-1,2,4-triazole
Purity
95%
Packaging
5g
Price
$617
Updated
2021/12/16
Crysdot
Product number
CD11147626
Product name
1-Trityl-1H-1,2,4-triazole
Purity
95+%
Packaging
5g
Price
$621
Updated
2021/12/16
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1-TRITYL-1H-1,2,4-TRIAZOLE Chemical Properties,Usage,Production

Synthesis

288-88-0

76-83-5

31250-99-4

Triethylamine (5.49 g, 54.30 mmol) was added to a solution of 1,2,4-triazole (3.0 g, 43.44 mmol) in N,N-dimethylformamide (DMF, 50 mL) at room temperature. After stirring for 5 min, triphenylchloromethane (12.11 g, 43.44 mmol) was added and the reaction mixture was stirred overnight at room temperature. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was partitioned between dichloromethane (50 mL) and water (50 mL) to separate the organic layer. The aqueous layer was extracted with dichloromethane (3 x 50 mL) and the organic layers were combined. The organic layer was washed with water (3 x 40 mL) and then dried over anhydrous sodium sulfate (Na2SO4). The organic layer was concentrated under reduced pressure to afford 1-trityl-1H-1,2,4-triazole (12.6 g, 93% yield). N-butyllithium (n-BuLi, 4.5 mL, 11.24 mmol; 2.5 M hexane solution) was added to a solution of tetrahydrofuran (THF, 120 mL) of 1-trityl-1H-1,2,4-triazole (3.5 g, 11.24 mmol) and stirred for 45 min at -78 °C. Bromine (1.76 g, 11.02 mmol) was added dropwise over 5 min and stirring was continued for 2 h at -78 °C. The reaction mixture was then allowed to slowly warm to -20°C and the reaction was quenched by addition of saturated ammonium chloride (NH4Cl) solution (30 mL). The reaction mixture was diluted with water (60 mL) and dichloromethane (40 mL) and the organic layer was separated. The aqueous layer was extracted with dichloromethane (4 x 50 mL) and the organic layers were combined. The organic layer was dried with anhydrous sodium sulfate (Na2SO4) and the solvent was evaporated under reduced pressure to give the crude product (4.2 g, 95% yield), which was used directly in the next step. Nuclear magnetic resonance hydrogen spectroscopy (1H NMR) data: δ 7.09-7.16 (m, 6H), 7.27-7.40 (m, 9H), 7.86 (s, 1H).

References

[1] Patent: WO2014/159248, 2014, A1. Location in patent: Paragraph 0185
[2] European Journal of Medicinal Chemistry, 2009, vol. 44, # 7, p. 3064 - 3067
[3] Tetrahedron, 1997, vol. 53, # 30, p. 10289 - 10312
[4] MedChemComm, 2014, vol. 5, # 1, p. 72 - 81
[5] Patent: US6620841, 2003, B1

1-TRITYL-1H-1,2,4-TRIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-TRITYL-1H-1,2,4-TRIAZOLE Suppliers

China 37 India 1 United States 1 Global 39
Matrix Scientific
Tel
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Fax
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Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
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View Lastest Price from 1-TRITYL-1H-1,2,4-TRIAZOLE manufacturers

Career Henan Chemical Co
Product
1-TRITYL-1H-1,2,4-TRIAZOLE 31250-99-4
Price
US $1.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
500KG
Release date
2018-08-19

31250-99-4, 1-TRITYL-1H-1,2,4-TRIAZOLERelated Search:

2-Methyl-4-isothiazolin-3-one 3-BROMO-1-TRITYL-1H-1,2,4-TRIAZOLE Fluotrimazol 1-BENZHYDRYL-1,2,4-TRIAZOLE 1-TRITYL-1H-1,2,4-TRIAZOLE-5-CARBALDEHYDE 1-TRITYL-1H-1,2,4-TRIAZOLE

  • 1-TRITYL-1H-1,2,4-TRIAZOLE
  • 1-(triphenylMethyl)-1H-1,2,4-Triazole
  • 1-trityl-1,2,4-triazole
  • 1H-1,2,4-Triazole, 1-(triphenylmethyl)-
  • 1-triphenylmethyl-1,2,4-triazole
  • 31250-99-4