KM 11060
- Product Name
- KM 11060
- CAS No.
- 774549-97-2
- Chemical Name
- KM 11060
- Synonyms
- KM 11060;KM11060;KM-11060;KM11060, 10 mM in DMSO;CFTR-F508del Corrector, KM11060;7-CHLORO-4-(4-(4-CHLOROPHENYLSULFONYL)PIPERAZIN-1-YL)QUINOLINE;7-CHLORO-4-[4-[4-CHLOROPHENYL)SULFONYL]-1-PIPERAZINYL]QUINOLINE;Quinoline, 7-chloro-4-[4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl]-;KM 11060,inhibit,KM11060,Inhibitor,Autophagy,Cystic fibrosis transmembrane conductance regulator,CFTR,KM-11060
- CBNumber
- CB02446666
- Molecular Formula
- C19H17Cl2N3O2S
- Formula Weight
- 422.33
- MOL File
- 774549-97-2.mol
KM 11060 Property
- storage temp.
- Store at RT
- solubility
- Soluble to 100 mM in DMSO and to 10 mM in ethanol
- form
- Powder
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 23481
- Product name
- KM 11060
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $90
- Updated
- 2024/03/01
- Product number
- 23481
- Product name
- KM 11060
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 23481
- Product name
- KM 11060
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $355
- Updated
- 2024/03/01
- Product number
- 23481
- Product name
- KM 11060
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $444
- Updated
- 2024/03/01
- Product number
- 3143
- Product name
- KM11060
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $483
- Updated
- 2021/12/16
KM 11060 Chemical Properties,Usage,Production
Uses
KM 11060 is a small molecular corrector of F508del CFTR trafficking, which has potential application in cystic fibrosis therapeutics.
Biological Activity
Corrects F508del-CFTR trafficking; increases the amount of functional CFTR at the plasma membrane (~75%). Shown to inhibit PDE5 activity.
Synthesis
98-60-2
837-52-5
774549-97-2
To a stirred solution of 7-chloro-4-(1-piperazinyl)quinoline (0.25 g, 1 mmol) in dichloromethane (8-10 mL) at 0 °C was added triethylamine (0.12 mL, 1.26 mmol). Subsequently, 4-chlorobenzenesulfonyl chloride (1 mmol) was added dropwise or in batches, and the reaction mixture was continued to be stirred at 0 °C for 15 min, then brought to room temperature and stirred until the reaction was complete (monitored by TLC). Upon completion of the reaction, the reaction mixture was diluted with dichloromethane (20 mL) and water (20 mL) and transferred to a partition funnel for separation. The organic layer was washed with water (3 x 20 mL) and dried over anhydrous sodium sulfate. Recrystallization by mixed solvent recrystallization of dichloromethane and hexane afforded pure 7-chloro-4-(4-((4-chlorophenyl)sulfonyl)-1-piperazinyl)quinoline in 85-95% yield.
in vivo
In LPS-induced acute lung inflammation, blockade of PSGL-1 (P-selectin glycoprotein ligand-1) or P-selectin, antagonism of PAF by WEB2086, or correction of mutated CFTR trafficking by KM11060 could significantly increase plasma lipoxin A4 levels in F508del relevant to wildtype mice. [2]
References
[1] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 11, p. 3080 - 3089
KM 11060 Preparation Products And Raw materials
Raw materials
Preparation Products
KM 11060 Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from KM 11060 manufacturers
- Product
- KM 11060 774549-97-2
- Price
- US $2.20-8.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons
- Release date
- 2025-07-08
- Product
- KM 11060 774549-97-2
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2019-12-23