ChemicalBook > CAS DataBase List > WS 12
WS 12
- Product Name
- WS 12
- CAS No.
- 68489-09-8
- Chemical Name
- WS 12
- Synonyms
- WS 12;AR-15512;Cooler-12;Acoltremon, 97%;Acoltremon, 97%;Cooling agent WS12;Cooler than menthol;WS 12, TRPM8 agonist;WS-12, 10 mM in DMSO;N-(4-Methoxyphenyl)-p-menthane-3-carboxamide
- CBNumber
- CB02455758
- Molecular Formula
- C18H27NO2
- Formula Weight
- 289.41
- MOL File
- 68489-09-8.mol
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WS 12 Property
- Boiling point:
- 447.8±28.0 °C(Predicted)
- Density
- 1.029±0.06 g/cm3(Predicted)
- vapor pressure
- 0-0Pa at 20-50℃
- FEMA
- 4681 | (1R,2S,5R)-N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE
- storage temp.
- -20°C
- solubility
- DMSO: >20mg/mL
- pka
- 14.18±0.70(Predicted)
- form
- White to off-white powder.
- color
- white to off-white
- Odor
- at 100.00 %. cool minty
- Odor Type
- minty
- JECFA Number
- 2079
- InChIKey
- HNSGVPAAXJJOPQ-XOKHGSTOSA-N
- LogP
- 3.95 at 22℃ and pH7.7
- CAS DataBase Reference
- 68489-09-8
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- W0519
- Product name
- WS-12
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5mg
- Price
- $194.75
- Updated
- 2025/07/31
Tocris
- Product number
- 3040
- Product name
- WS12
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $590
- Updated
- 2021/12/16
Tocris
- Product number
- 3040
- Product name
- WS12
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $141
- Updated
- 2021/12/16
TRC
- Product number
- W500040
- Product name
- WS12
- Packaging
- 10mg
- Price
- $105
- Updated
- 2021/12/16
TRC
- Product number
- W500040
- Product name
- WS12
- Packaging
- 25mg
- Price
- $210
- Updated
- 2021/12/16
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WS 12 Chemical Properties,Usage,Production
Description
WS-12 is an agonist of transient receptor potential melastatin 8 (TRPM8). It induces currents in Xenopus oocytes expressing mouse TRPM8 (EC50 = 12 μM) and is selective for TRPM8 over transient receptor potential vanilloid 1-4 (TRPV1-4) and transient receptor potential ankyrin 1 (TRPA1) at 1 mM. WS-12 (6 nmol, i.c.v.) reduces nocifensive behavior induced by capsaicin in wild-type, but not Trpm8-/-, mice. It induces analgesia in the hot plate test, an effect that can be reversed by the opioid receptor antagonist naloxone, in mice.
Chemical Properties
WS 12 is a odorless white crystalline solid,mp 178 °C, displaying a strong initial cooling effect and a long-lastingness. It is used particularly is oral care flavors.
Uses
WS 12 is a potent TRPM8 agonist.
Trade name
Winsense WS-12 (Renessenz)
Biological Activity
Potent TRPM8 agonist that acts as a cooling agent (EC 50 = 193 nM).
Biochem/physiol Actions
WS-12 is a menthol derivative, that shows a specific binding affinity towards TRPM8 (transient receptor potential cation channel subfamily M member 8) receptor. TRPM8 is associated with prostate cancer and thus, WS-12 might be useful in reducing the progression of cancer.
storage
Store at -20°C
References
[1] SHERKHELI MA. Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels.[J]. Pakistan journal of pharmaceutical sciences, 2008, 21 4: 370-378.
[2] BOYI LIU . TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain[J]. PAIN?, 2013, 154 10: Pages 2169-2177. DOI: 10.1016/j.pain.2013.06.043
WS 12 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from WS 12 manufacturers
Hebei Zhuanglai Chemical Trading Co.,Ltd
- Product
- Cooling agent WS-12 68489-09-8
- Price
- US $25.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000kg/week
- Release date
- 2024-04-25
Shaanxi Dideu Medichem Co. Ltd
- Product
- WS 12 68489-09-8
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2024-07-18
Hebei Lunzhi Import and Export Trade CO.,LLT
- Product
- L-Menthyl Lactate 68489-09-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 20tons
- Release date
- 2023-02-07
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